Scientific Publications of the Collaborative Research Center 1365

López-Cayuqueo KI, Planells-Cases R, Pietzke M, Oliveras A, Kempa S, Bachmann S, Jentsch TJ:
Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.
J Am Soc Nephrol. 2022 Jul 1;33(8):1528-45. doi: 10.1681/ASN.2021111458. Online ahead of print. PMID: 35777784

Labes R, Brinkmann L, Kulow VA, Roegner K, Mathia S, Balcerek B, Persson PB, Rosenberger C, Fähling M:
Daprodustat prevents cyclosporine-A mediated anemia and peritubular capillary loss.
Kidney Int. 2022 May 26:S0085-2538(22)00375-1. doi: 10.1016/j.kint.2022.04.025. Online ahead of print. PMID: 35643373

Zacharias HU, Altenbuchinger M, Schultheiss UT, Raffler J, Kotsis F, Ghasemi S, Ali I, Kollerits B, Metzger M, Steinbrenner I, Sekula P, Massy ZA, Combe C, Kalra PA, Kronenberg F, Stengel B, Eckardt KU, Köttgen A, Schmid M, Gronwald W, Oefner PJ; GCKD Investigators:
A Predictive Model for Progression of CKD to Kidney Failure Based on Routine Laboratory Tests.
Am J Kidney Dis. 2022 Feb;79(2):217-230.e1. doi: 10.1053/j.ajkd.2021.05.018. Epub 2021 Jul 20. PMID: 34298143

Schneider MP, Schmid M, Nadal J, Wanner C, Krane V, Floege J, Saritas T, Busch M, Sitter T, Friedrich N, Stockmann H, Meiselbach H, Nauck M, Kronenberg F, Eckardt KU; GCKD Study Investigators:
Heart-Type Fatty Acid Binding Protein, Cardiovascular Outcomes, and Death: Findings From the German CKD Cohort Study.
Am J Kidney Dis. 2022 Mar 11:S0272-6386(22)00526-1. doi: 10.1053/j.ajkd.2022.01.424. Online ahead of print. PMID: 35288215
https://www.ajkd.org/article/S0272-6386(22)00526-1/fulltext

Joseph CB, Mariniello M, Yoshifuji A, Schiano G, Lake J, Marten J, Richmond A, Huffman JE, Campbell A, Harris SE, Troyanov S, Cocca M, Robino A, Thériault S, Eckardt KU, Wuttke M, Cheng Y, Corre T, Kolcic I, Black C, Bruat V, Concas MP, Sala C, Aeschbacher S, Schaefer F, Bergmann S, Campbell H, Olden M, Polasek O, Porteous DJ, Deary IJ, Madore F, Awadalla P, Girotto G, Ulivi S, Conen D, Wuehl E, Olinger E, Wilson JF, Bochud M, Köttgen A, Hayward C, Devuyst O:
Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin.
J Am Soc Nephrol. 2022 Mar;33(3):511-529. doi: 10.1681/ASN.2021040491. PMID: 35228297

Schwaiger JP, Kollerits B, Steinbrenner I, Weissensteiner H, Schönherr S, Forer L, Kotsis F, Lamina C, Schneider MP, Schultheiss UT, Wanner C, Köttgen A, Eckardt KU, Kronenberg F; GCKD Investigators:
Apolipoprotein A-IV concentrations and clinical outcomes in a large chronic kidney disease cohort: Results from the GCKD study.
J Intern Med. 2022 May;291(5):622-636. doi: 10.1111/joim.13437. Epub 2022 Jan 4. PMID: 34914850
https://onlinelibrary.wiley.com/doi/10.1111/joim.13437

Kheirkhah A, Lamina C, Kollerits B, Schachtl-Riess JF, Schultheiss UT, Forer L, Sekula P, Kotsis F, Eckardt KU, Kronenberg F; GCKD Investigators:
PCSK9 and Cardiovascular Disease in Individuals with Moderately Decreased Kidney Function.
Clin J Am Soc Nephrol. 2022 Jun;17(6):809-818. doi: 10.2215/CJN.01230122. Epub 2022 Apr 6. PMID: 35387881

Gorski M, Rasheed H, Teumer A, Thomas LF, Graham SE, Sveinbjornsson G, Winkler TW, Günther F, Stark KJ, Chai JF, Tayo BO, Wuttke M, Li Y, Tin A, Ahluwalia TS, Ärnlöv J, Åsvold BO, Bakker SJL, Banas B, Bansal N, Biggs ML, Biino G, Böhnke M, Boerwinkle E, Bottinger EP, Brenner H, Brumpton B, Carroll RJ, Chaker L, Chalmers J, Chee ML, Chee ML, Cheng CY, Chu AY, Ciullo M, Cocca M, Cook JP, Coresh J, Cusi D, de Borst MH, Degenhardt F, Eckardt KU, Endlich K, Evans MK, Feitosa MF, Franke A, Freitag-Wolf S, Fuchsberger C, Gampawar P, Gansevoort RT, Ghanbari M, Ghasemi S, Giedraitis V, Gieger C, Gudbjartsson DF, Hallan S, Hamet P, Hishida A, Ho K, Hofer E, Holleczek B, Holm H, Hoppmann A, Horn K, Hutri-Kähönen N, Hveem K, Hwang SJ, Ikram MA, Josyula NS, Jung B, Kähönen M, Karabegović I, Khor CC, Koenig W, Kramer H, Krämer BK, Kühnel B, Kuusisto J, Laakso M, Lange LA, Lehtimäki T, Li M, Lieb W; Lifelines Cohort Study, Lind L, Lindgren CM, Loos RJF, Lukas MA, Lyytikäinen LP, Mahajan A, Matias-Garcia PR, Meisinger C, Meitinger T, Melander O, Milaneschi Y, Mishra PP, Mononen N, Morris AP, Mychaleckyj JC, Nadkarni GN, Naito M, Nakatochi M, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Nutile T, O'Donoghue ML, O'Connell J, Olafsson I, Orho-Melander M, Parsa A, Pendergrass SA, Penninx BWJH, Pirastu M, Preuss MH, Psaty BM, Raffield LM, Raitakari OT, Rheinberger M, Rice KM, Rizzi F, Rosenkranz AR, Rossing P, Rotter JI, Ruggiero D, Ryan KA, Sabanayagam C, Salvi E, Schmidt H, Schmidt R, Scholz M, Schöttker B, Schulz CA, Sedaghat S, Shaffer CM, Sieber KB, Sim X, Sims M, Snieder H, Stanzick KJ, Thorsteinsdottir U, Stocker H, Strauch K, Stringham HM, Sulem P, Szymczak S, Taylor KD, Thio CHL, Tremblay J, Vaccargiu S, van der Harst P, van der Most PJ, Verweij N, Völker U, Wakai K, Waldenberger M, Wallentin L, Wallner S, Wang J, Waterworth DM, White HD, Willer CJ, Wong TY, Woodward M, Yang Q, Yerges-Armstrong LM, Zimmermann M, Zonderman AB, Bergler T, Stefansson K, Böger CA, Pattaro C, Köttgen A, Kronenberg F, Heid IM:
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.
Kidney Int. 2022 Jun 16:S0085-2538(22)00454-9. doi: 10.1016/j.kint.2022.05.021. Online ahead of print. PMID: 35716955

Zhou S, Guo J, Liao X, Zhou Q, Qiu X, Jiang S, Xu N, Wang X, Zhao L, Hu W, Xie L, Xie P, Cui Y, Yang Y, Patzak A, Persson PB, Mao J, Lai EY:
rhADAMTS13 reduces oxidative stress by cleaving VWF in ischaemia/reperfusion-induced acute kidney injury.
Acta Physiol 2022 Mar 234(3):e13778. Doi:10.1111/apha.13778 PMID: 34989474

Markó L, Dörr A, Linz P, van den Meiracker AH, Garrelds IM, Kuehne T, Dechend R, Danser AHJ, Flörcken A, Müller DN:
Effect of Sunitinib Treatment on Skin Sodium Accumulation in Patients With Renal Cancer: a Pilot Study.
Hypertension. 2022 Feb 22:HYPERTENSIONAHA12219079. doi: 10.1161/HYPERTENSIONAHA.122.19079. Online ahead of print. PMID:35189705

Dong F, Jiang S, Tang C, Wang X, Ren X, Wei Q, Tian J, Hu W, Guo J, Fu X, Liu L, Patzak A, Persson PB, Gao F, Lai EY, Zhao L:
Trimethylamine N-oxide promotes hyperoxaluria-induced calcium oxalate deposition and kidney injury by activating autophagy.
Free Radic Biol Med 2022 Feb 1; 179:288-300. Doi: 10.1016/j.freeradbiomed.2021.11.010 PMID: 34767921

Münch J, Engesser M, Schönauer R, Hamm JA, Hartig C, Hantmann E, Akay G, Pehlivan D, Mitani T, Coban Akdemir Z, Tüysüz B, Shirakawa T, Dateki S, Claus LR, van Eerde AM; Genomics England Research Consortium, Smol T, Devisme L, Franquet H, Attié-Bitach T, Wagner T, Bergmann C, Höhn AK, Shril S, Pollack A, Wegner T, Scott A, Paolucci S, Buchan J, Gabriel GC, Posey JE, Lupski JR, Petit F, McCarthy AA, Pazour GJ, Lo CW, Popp B, Halbritter J:
Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract.
Kidney Int. 2022 Feb 26:S0085-2538(22)00157-0. doi: 10.1016/j.kint.2022.01.028. Online ahead of print. PMID: 35227688

Rosenberger C:
Semaphorin class 3C, vascular permeability, and the swollen injured kidney.
Kidney Int. 2022 Apr;101(4):670-673. doi: 10.1016/j.kint.2022.01.015. PMID: 35314049

Abdirama D, Tesch S, Grießbach AS, von Spee-Mayer C, Humrich JY, Stervbo U, Babel N, Meisel C, Alexander T, Biesen R, Bacher P, Scheffold A, Eckardt KU, Hiepe F, Radbruch A, Burmester GR, Riemekasten G, Enghard P:
Nuclear antigen-reactive CD4+ T cells expand in active systemic lupus erythematosus, produce effector cytokines, and invade the kidneys.
Kidney Int. 2021 Jan;99(1):238-246. doi: 10.1016/j.kint.2020.05.051. Epub 2020 Jun 24. PMID: 32592813

Enghard P, Zickler D, Sonnemann J, Schneider W, Lurje G, Elezkurtaj S, Eckardt KU, Schreiber A:
Imlifidase as novel treatment strategy in anti-neutrophil cytoplasmic antibody-induced pulmonary-renal syndrome.
Kidney Int. 2021 Dec;100(6):1344-1345. doi: 10.1016/j.kint.2021.09.020. PMID: 34802561

Servais A, Thomas K, Dello Strologo L, Sayer JA, Bekri S, Bertholet-Thomas A, Bultitude M, Capolongo G, Cerkauskiene R, Daudon M, Doizi S, Gillion V, Gràcia-Garcia S, Halbritter J, Heidet L, van den Heijkant M, Lemoine S, Knebelmann B, Emma F, Levtchenko E; Metabolic Nephropathy Workgroup of the European Reference Network for Rare Kidney Diseases (ERKNet) and eUROGEN:
Cystinuria: clinical practice recommendation.
Kidney Int. 2021 Jan;99(1):48-58. doi: 10.1016/j.kint.2020.06.035. Epub 2020 Sep 9. PMID: 32918941

Zhang Y, Xu C, Ye Q, Tong L, Jiang H, Zhu X, Huang L, Lin W, Fu H, Wang J, Persson PB, Lai EY, Mao J:
Podocyte apoptosis in diabetic nephropathy by BASP1 activation of the p53 pathway via WT1.
Acta Physiol 2021 May, 232(1):e13634. Doi: 10.1111/apha.13634. PMID: 33615732

Wennysia IC, Zhao L, Schomber T, Braun D, Golz S, Summer H, Benardeau A, Lai EY, Lichtenberger FB, Schubert R, Persson PB, Xu MZ, Patzak A:
Role of soluble guanylyl cyclase in renal afferent and efferent arterioles.
Am J Physiol Renal Physiol 2021 Feb 1; 320(2):F193-F202. Doi: 10.1152/ajprenal.00272.2020. PMID: 33356952

Marahrens B, Schulze A, Wysocki J, Lin MH, Ye M, Kanwar YS, Bader M, Velez JCQ, Miner JH, Batlle D:
Knockout of aminopeptidase A in mice causes functional alterations and morphological glomerular basement membrane changes in the kidneys.
Kidney Int. 2021 Apr;99(4):900-913. doi: 10.1016/j.kint.2020.11.012. Epub 2020 Dec 11. PMID: 33316280

Gupta S, Short SAP, Sise ME, Prosek JM, Madhavan SM, Soler MJ, Ostermann M, Herrmann SM, Abudayyeh A, Anand S, Glezerman I, Motwani SS, Murakami N, Wanchoo R, Ortiz-Melo DI, Rashidi A, Sprangers B, Aggarwal V, Malik AB, Loew S, Carlos CA, Chang WT, Beckerman P, Mithani Z, Shah CV, Renaghan AD, Seigneux S, Campedel L, Kitchlu A, Shin DS, Rangarajan S, Deshpande P, Coppock G, Eijgelsheim M, Seethapathy H, Lee MD, Strohbehn IA, Owen DH, Husain M, Garcia-Carro C, Bermejo S, Lumlertgul N, Seylanova N, Flanders L, Isik B, Mamlouk O, Lin JS, Garcia P, Kaghazchi A, Khanin Y, Kansal SK, Wauters E, Chandra S, Schmidt-Ott KM, Hsu RK, Tio MC, Sarvode Mothi S, Singh H, Schrag D, Jhaveri KD, Reynolds KL, Cortazar FB, Leaf DE; ICPi-AKI Consortium Investigators:
Acute kidney injury in patients treated with immune checkpoint inhibitors.
J Immunother Cancer. 2021 Oct;9(10):e003467. doi: 10.1136/jitc-2021-003467. PMID: 34625513

Alzahrani AS, Hussein M, Alswailem M, Mouna A, Albalawi L, Moria Y, Jabbar MA, Shi Y, Günzel D, Dasouki M:
A novel claudin-10 mutation with a unique mechanism in two unrelated families with HELIX syndrome.
Kidney Int. 2021 Aug;100(2):415-429. doi: 10.1016/j.kint.2021.02.023. Epub 2021 Mar 3. PMID: 33675844

Schrezenmeier E, Rincon-Arevalo H, Stefanski AL, Potekhin A, Straub-Hohenbleicher H, Choi M, Bachmann F, Pross V, Hammett C, Schrezenmeier H, Ludwig C, Jahrsdörfer B, Lino A, Eckardt KU, Kotsch K, Döerner T, Budde K, Sattler A, Halleck F:
B and T Cell Responses after a Third Dose of SARS-CoV-2 Vaccine in Kidney Transplant Recipients.
J Am Soc Nephrol. 2021 Oct 19;32(12):3027-33. doi: 10.1681/ASN.2021070966. PMID: 34667083

Schlosser P, Tin A, Matias-Garcia PR, Thio CHL, Joehanes R, Liu H, Weihs A, Yu Z, Hoppmann A, Grundner-Culemann F, Min JL, Adeyemo AA, Agyemang C, Ärnlöv J, Aziz NA, Baccarelli A, Bochud M, Brenner H, Breteler MMB, Carmeli C, Chaker L, Chambers JC, Cole SA, Coresh J, Corre T, Correa A, Cox SR, de Klein N, Delgado GE, Domingo-Relloso A, Eckardt KU, Ekici AB, Endlich K, Evans KL, Floyd JS, Fornage M, Franke L, Fraszczyk E, Gao X, Gào X, Ghanbari M, Ghasemi S, Gieger C, Greenland P, Grove ML, Harris SE, Hemani G, Henneman P, Herder C, Horvath S, Hou L, Hurme MA, Hwang SJ, Jarvelin MR, Kardia SLR, Kasela S, Kleber ME, Koenig W, Kooner JS, Kramer H, Kronenberg F, Kühnel B, Lehtimäki T, Lind L, Liu D, Liu Y, Lloyd-Jones DM, Lohman K, Lorkowski S, Lu AT, Marioni RE, März W, McCartney DL, Meeks KAC, Milani L, Mishra PP, Nauck M, Navas-Acien A, Nowak C, Peters A, Prokisch H, Psaty BM, Raitakari OT, Ratliff SM, Reiner AP, Rosas SE, Schöttker B, Schwartz J, Sedaghat S, Smith JA, Sotoodehnia N, Stocker HR, Stringhini S, Sundström J, Swenson BR, Tellez-Plaza M, van Meurs JBJ, van Vliet-Ostaptchouk JV, Venema A, Verweij N, Walker RM, Wielscher M, Winkelmann J, Wolffenbuttel BHR, Zhao W, Zheng Y; Estonian Biobank Research Team; Genetics of DNA Methylation Consortium, Loh M, Snieder H, Levy D, Waldenberger M, Susztak K, Köttgen A, Teumer A:
Meta-analyses identify DNA methylation associated with kidney function and damage.
Nat Commun. 2021 Dec 9;12(1):7174. doi: 10.1038/s41467-021-27234-3. PMID: 34887417

Choi M, Krueger A, Mogl M, Hsiao M, Jung C, Pasch A, Voelkl J, Eckardt KU, Hillen U:
The Case | A nonhealing skin ulcer in a patient 5 years after successful transplantation.
Kidney Int. 2021 Dec;100(6):1357-1358. doi: 10.1016/j.kint.2021.06.015. PMID: 34802570

Pammer LM, Lamina C, Schultheiss UT, Kotsis F, Kollerits B, Stockmann H, Lipovsek J, Meiselbach H, Busch M, Eckardt KU, Kronenberg F; GCKD Investigators:
Association of the metabolic syndrome with mortality and major adverse cardiac events: A large chronic kidney disease cohort.
J Intern Med. 2021 Dec;290(6):1219-1232. doi: 10.1111/joim.13355. Epub 2021 Aug 3. PMID: 34342064
https://onlinelibrary.wiley.com/doi/10.1111/joim.13355

Wish JB, Eckardt KU, Kovesdy CP, Fishbane S, Spinowitz BS, Berns JS:
Hypoxia-Inducible Factor Stabilization as an Emerging Therapy for CKD-Related Anemia: Report From a Scientific Workshop Sponsored by the National Kidney Foundation.
Am J Kidney Dis. 2021 Nov;78(5):709-718. doi: 10.1053/j.ajkd.2021.06.019. Epub 2021 Jul 28. PMID: 34332007

Steinbrenner I, Schultheiss UT, Kotsis F, Schlosser P, Stockmann H, Mohney RP, Schmid M, Oefner PJ, Eckardt KU, Köttgen A, Sekula P; German Chronic Kidney Disease Investigators:
Urine Metabolite Levels, Adverse Kidney Outcomes, and Mortality in CKD Patients: A Metabolome-wide Association Study.
Am J Kidney Dis. 2021 Nov;78(5):669-677.e1. doi: 10.1053/j.ajkd.2021.01.018. Epub 2021 Apr 9. PMID: 33839201
https://www.ajkd.org/article/S0272-6386(21)00508-4/fulltext

Pfau A, Ermer T, Coca SG, Tio MC, Genser B, Reichel M, Finkelstein FO, März W, Wanner C, Waikar SS, Eckardt KU, Aronson PS, Drechsler C, Knauf F:
High Oxalate Concentrations Correlate with Increased Risk for Sudden Cardiac Death in Dialysis Patients.
J Am Soc Nephrol. 2021 Sep;32(9):2375-2385. doi: 10.1681/ASN.2020121793. Epub 2021 Jul 19. PMID: 34281958

Kotsis F, Schultheiss UT, Wuttke M, Schlosser P, Mielke J, Becker MS, Oefner PJ, Karoly ED, Mohney RP, Eckardt KU, Sekula P, Köttgen A; GCKD Investigators:
Self-Reported Medication Use and Urinary Drug Metabolites in the German Chronic Kidney Disease (GCKD) Study.
J Am Soc Nephrol. 2021 Sep;32(9):2315-2329. doi: 10.1681/ASN.2021010063. Epub 2021 Jun 17. PMID: 34140400

Babitt JL, Eisenga MF, Haase VH, Kshirsagar AV, Levin A, Locatelli F, Małyszko J, Swinkels DW, Tarng DC, Cheung M, Jadoul M, Winkelmayer WC, Drüeke TB; Conference Participants:
Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.
Kidney Int. 2021 Jun;99(6):1280-1295. doi: 10.1016/j.kint.2021.03.020. Epub 2021 Apr 8. PMID: 33839163

Eckardt KU, Agarwal R, Aswad A, Awad A, Block GA, Bacci MR, Farag YMK, Fishbane S, Hubert H, Jardine A, Khawaja Z, Koury MJ, Maroni BJ, Matsushita K, McCullough PA, Lewis EF, Luo W, Parfrey PS, Pergola P, Sarnak MJ, Spinowitz B, Tumlin J, Vargo DL, Walters KA, Winkelmayer WC, Wittes J, Zwiech R, Chertow GM:
Safety and Efficacy of Vadadustat for Anemia in Patients Undergoing Dialysis.
N Engl J Med. 2021 Apr 29;384(17):1601-1612. doi: 10.1056/NEJMoa2025956. PMID: 33913638

Chertow GM, Pergola PE, Farag YMK, Agarwal R, Arnold S, Bako G, Block GA, Burke S, Castillo FP, Jardine AG, Khawaja Z, Koury MJ, Lewis EF, Lin T, Luo W, Maroni BJ, Matsushita K, McCullough PA, Parfrey PS, Roy-Chaudhury P, Sarnak MJ, Sharma A, Spinowitz B, Tseng C, Tumlin J, Vargo DL, Walters KA, Winkelmayer WC, Wittes J, Eckardt KU; PRO2TECT Study Group:
Vadadustat in Patients with Anemia and Non-Dialysis-Dependent CKD.
N Engl J Med. 2021 Apr 29;384(17):1589-1600. doi: 10.1056/NEJMoa2035938. PMID: 33913637

Gorski M, Jung B, Li Y, Matias-Garcia PR, Wuttke M, Coassin S, Thio CHL, Kleber ME, Winkler TW, Wanner V, Chai JF, Chu AY, Cocca M, Feitosa MF, Ghasemi S, Hoppmann A, Horn K, Li M, Nutile T, Scholz M, Sieber KB, Teumer A, Tin A, Wang J, Tayo BO, Ahluwalia TS, Almgren P, Bakker SJL, Banas B, Bansal N, Biggs ML, Boerwinkle E, Bottinger EP, Brenner H, Carroll RJ, Chalmers J, Chee ML, Chee ML, Cheng CY, Coresh J, de Borst MH, Degenhardt F, Eckardt KU, Endlich K, Franke A, Freitag-Wolf S, Gampawar P, Gansevoort RT, Ghanbari M, Gieger C, Hamet P, Ho K, Hofer E, Holleczek B, Xian Foo VH, Hutri-Kähönen N, Hwang SJ, Ikram MA, Josyula NS, Kähönen M, Khor CC, Koenig W, Kramer H, Krämer BK, Kühnel B, Lange LA, Lehtimäki T, Lieb W; Lifelines Cohort Study; Regeneron Genetics Center, Loos RJF, Lukas MA, Lyytikäinen LP, Meisinger C, Meitinger T, Melander O, Milaneschi Y, Mishra PP, Mononen N, Mychaleckyj JC, Nadkarni GN, Nauck M, Nikus K, Ning B, Nolte IM, O'Donoghue ML, Orho-Melander M, Pendergrass SA, Penninx BWJH, Preuss MH, Psaty BM, Raffield LM, Raitakari OT, Rettig R, Rheinberger M, Rice KM, Rosenkranz AR, Rossing P, Rotter JI, Sabanayagam C, Schmidt H, Schmidt R, Schöttker B, Schulz CA, Sedaghat S, Shaffer CM, Strauch K, Szymczak S, Taylor KD, Tremblay J, Chaker L, van der Harst P, van der Most PJ, Verweij N, Völker U, Waldenberger M, Wallentin L, Waterworth DM, White HD, Wilson JG, Wong TY, Woodward M, Yang Q, Yasuda M, Yerges-Armstrong LM, Zhang Y, Snieder H, Wanner C, Böger CA, Köttgen A, Kronenberg F, Pattaro C, Heid IM:
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline.
Kidney Int. 2021 Apr;99(4):926-939. doi: 10.1016/j.kint.2020.09.030. Epub 2020 Oct 31. PMID: 33137338

Cheng Y, Schlosser P, Hertel J, Sekula P, Oefner PJ, Spiekerkoetter U, Mielke J, Freitag DF, Schmidts M; GCKD Investigators, Kronenberg F, Eckardt KU, Thiele I, Li Y, Köttgen A:
Rare genetic variants affecting urine metabolite levels link population variation to inborn errors of metabolism.
Nat Commun. 2021 Feb 11;12(1):964. doi: 10.1038/s41467-020-20877-8. PMID: 33574263

Witting C, Langman CB, Assimos D, Baum MA, Kausz A, Milliner D, Tasian G, Worcester E, Allain M, West M, Knauf F, Lieske JC:
Pathophysiology and Treatment of Enteric Hyperoxaluria.
Clin J Am Soc Nephrol. 2021 Mar 8;16(3):487-495. doi: 10.2215/CJN.08000520. Epub 2020 Sep 8. PMID: 32900691

Cho Y, Tong A, Craig JC, Mustafa RA, Chapman A, Perrone RD, Ahn C, Fowler K, Torres V, Gansevoort RT, Ong ACM, Coolican H, Tze-Wah Kao J, Harris T, Gutman T, Shen JI, Viecelli AK, Johnson DW, Au E, El-Damanawi R, Logeman C, Ju A, Manera KE, Chonchol M, Odland D, Baron D, Pei Y, Sautenet B, Rastogi A, Sharma A, Rangan G; SONG-PKD Workshop Investigators:
Establishing a Core Outcome Set for Autosomal Dominant Polycystic Kidney Disease: Report of the Standardized Outcomes in Nephrology-Polycystic Kidney Disease (SONG-PKD) Consensus Workshop.
Am J Kidney Dis. 2021 Feb;77(2):255-263. doi: 10.1053/j.ajkd.2020.05.024. Epub 2020 Aug 6. PMID: 32771648

Mayrdorfer M, Liefeldt L, Wu K, Rudolph B, Zhang Q, Friedersdorff F, Lachmann N, Schmidt D, Osmanodja B, Naik MG, Duettmann W, Halleck F, Merkel M, Schrezenmeier E, Waiser J, Duerr M, Budde K:
Exploring the Complexity of Death-Censored Kidney Allograft Failure.
J Am Soc Nephrol. 2021 Jun 1;32(6):1513-1526. doi: 10.1681/ASN.2020081215. Epub 2021 Apr 21. PMID: 33883251

Dornieden T, Sattler A, Pascual-Reguant A, Ruhm AH, Thiel LG, Bergmann YS, Thole LML, Köhler R, Kühl AA, Hauser AE, Boral S, Friedersdorff F, Kotsch K:
Signatures and Specificity of Tissue-Resident Lymphocytes Identified in Human Renal Peritumor and Tumor Tissue.
J Am Soc Nephrol. 2021 Sep;32(9):2223-2241. doi: 10.1681/ASN.2020101528. Epub 2021 Jun 1. PMID: 34074699

Majmundar AJ, Buerger F, Forbes TA, Klämbt V, Schneider R, Deutsch K, Kitzler TM, Howden SE, Scurr M, Tan KS, Krzeminski M, Widmeier E, Braun DA, Lai E, Ullah I, Amar A, Kolb A, Eddy K, Chen CH, Salmanullah D, Dai R, Nakayama M, Ottlewski I, Kolvenbach CM, Onuchic-Whitford AC, Mao Y, Mann N, Nabhan MM, Rosen S, Forman-Kay JD, Soliman NA, Heilos A, Kain R, Aufricht C, Mane S, Lifton RP, Shril S, Little MH, Hildebrandt F:
Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice.
Sci Adv. 2021 Jan 1;7(1):eabe1386. doi: 10.1126/sciadv.abe1386. Print 2021 Jan. PMID: 33523862

Schlingmann KP, Jouret F, Shen K, Nigam A, Arjona FJ, Dafinger C, Houillier P, Jones DP, Kleinerüschkamp F, Oh J, Godefroid N, Eltan M, Güran T, Burtey S, Parotte MC, König J, Braun A, Bos C, Ibars Serra M, Rehmann H, Zwartkruis FJT, Renkema KY, Klingel K, Schulze-Bahr E, Schermer B, Bergmann C, Altmüller J, Thiele H, Beck BB, Dahan K, Sabatini D, Liebau MC, Vargas-Poussou R, Knoers NVAM, Konrad M, de Baaij JHF:
mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy.
J Am Soc Nephrol. 2021 Nov;32(11):2885-2899. doi: 10.1681/ASN.2021030333. Epub 2021 Oct 4. PMID: 34607910

Roemhild A, Otto NM, Moll G, Abou-El-Enein M, Kaiser D, Bold G, Schachtner T, Choi M, Oellinger R, Landwehr-Kenzel S, Juerchott K, Sawitzki B, Giesler C, Sefrin A, Beier C, Wagner DL, Schlickeiser S, Streitz M, Schmueck-Henneresse M, Amini L, Stervbo U, Babel N, Volk HD, Reinke P:
Regulatory T cells for minimising immune suppression in kidney transplantation: phase I/IIa clinical trial.
BMJ. 2020 Oct 21;371:m3734. doi: 10.1136/bmj.m3734. PMID: 33087345

Sawitzki B, Harden PN, Reinke P, Moreau A, Hutchinson JA, Game DS, Tang Q, Guinan EC, Battaglia M, Burlingham WJ, Roberts ISD, Streitz M, Josien R, Böger CA, Scottà C, Markmann JF, Hester JL, Juerchott K, Braudeau C, James B, Contreras-Ruiz L, van der Net JB, Bergler T, Caldara R, Petchey W, Edinger M, Dupas N, Kapinsky M, Mutzbauer I, Otto NM, Öllinger R, Hernandez-Fuentes MP, Issa F, Ahrens N, Meyenberg C, Karitzky S, Kunzendorf U, Knechtle SJ, Grinyó J, Morris PJ, Brent L, Bushell A, Turka LA, Bluestone JA, Lechler RI, Schlitt HJ, Cuturi MC, Schlickeiser S, Friend PJ, Miloud T, Scheffold A, Secchi A, Crisalli K, Kang SM, Hilton R, Banas B, Blancho G, Volk HD, Lombardi G, Wood KJ, Geissler EK:
Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.
Lancet. 2020 May 23;395(10237):1627-1639. doi: 10.1016/S0140-6736(20)30167-7. PMID: 32446407

Schneider R, Deutsch K, Hoeprich GJ, Marquez J, Hermle T, Braun DA, Seltzsam S, Kitzler TM, Mao Y, Buerger F, Majmundar AJ, Onuchic-Whitford AC, Kolvenbach CM, Schierbaum L, Schneider S, Halawi AA, Nakayama M, Mann N, Connaughton DM, Klämbt V, Wagner M, Riedhammer KM, Renders L, Katsura Y, Thumkeo D, Soliman NA, Mane S, Lifton RP, Shril S, Khokha MK, Hoefele J, Goode BL, Hildebrandt F:
DAAM2 Variants Cause Nephrotic Syndrome via Actin Dysregulation.
Am J Hum Genet. 2020 Dec 3;107(6):1113-1128. doi: 10.1016/j.ajhg.2020.11.008. Epub 2020 Nov 23.  PMID: 33232676

Xu N, Jiang S, Persson PB, Persson EAG, Lai EY, Patzak A:
Reactive oxygen species in renal vascular function.
Acta Physiol 2020 Aug;229(4):e13477. Doi: 10.1111/apha.13477. PMID: 32311827

Simons M, Bader M, Müller DN:
The (pro)renin receptor: what's in a name?
Nat Rev Nephrol. 2020 May;16(5):304. doi: 10.1038/s41581-020-0274-9. PMID: 32238922

Markó L, Park JK, Henke N, Rong S, Balogh A, Klamer S, Bartolomaeus H, Wilck N, Ruland J, Forslund SK, Luft FC, Dechend R, Müller DN:
B-cell lymphoma/leukaemia 10 and angiotensin II-induced kidney injury.
Cardiovasc Res. 2020 Apr 1;116(5):1059-1070. doi: 10.1093/cvr/cvz169. PMID: 31241148

Serfozo P, Wysocki J, Gulua G, Schulze A, Ye M, Liu P, Jin J, Bader M, Myöhänen T, García-Horsman JA, Batlle D:
Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent.
Hypertension. 2020 Jan;75(1):173-182. doi: 10.1161/HYPERTENSIONAHA.119.14071. Epub 2019 Dec 2. PMID: 31786979

Schmidt-Ott KM:
Mix for Regeneration: Nephron Replacement by Transplanted Cells.
J Am Soc Nephrol. 2020 Dec;31(12):2743-2745. doi: 10.1681/ASN.2020091350. Epub 2020 Nov 5. PMID: 33154176

Schönauer R, Jin W, Ertel A, Nemitz-Kliemchen M, Panitz N, Hantmann E, Seidel A, Braun DA, Shril S, Hansen M, Shahzad K, Sandford R, Saunier S, Benmerah A, Bergmann C, Hildebrandt F, Halbritter J:
Novel nephronophthisis-associated variants reveal functional importance of MAPKBP1 dimerization for centriolar recruitment.
Kidney Int. 2020 Oct;98(4):958-969. doi: 10.1016/j.kint.2020.05.027. Epub 2020 Jun 4. PMID: 32505465

Bayraktar S, Nehrig J, Menis E, Karli K, Janning A, Struk T, Halbritter J, Michgehl U, Krahn MP, Schuberth CE, Pavenstädt H, Wedlich-Söldner R:
A Deregulated Stress Response Underlies Distinct INF2-Associated Disease Profiles.
J Am Soc Nephrol. 2020 Jun;31(6):1296-1313. doi: 10.1681/ASN.2019111174. PMID: 32444357

Connaughton DM, Dai R, Owen DJ, Marquez J, Mann N, Graham-Paquin AL, Nakayama M, Coyaud E, Laurent EMN, St-Germain JR, Blok LS, Vino A, Klämbt V, Deutsch K, Wu CW, Kolvenbach CM, Kause F, Ottlewski I, Schneider R, Kitzler TM, Majmundar AJ, Buerger F, Onuchic-Whitford AC, Youying M, Kolb A, Salmanullah D, Chen E, van der Ven AT, Rao J, Ityel H, Seltzsam S, Rieke JM, Chen J, Vivante A, Hwang DY, Kohl S, Dworschak GC, Hermle T, Alders M, Bartolomaeus T, Bauer SB, Baum MA, Brilstra EH, Challman TD, Zyskind J, Costin CE, Dipple KM, Duijkers FA, Ferguson M, Fitzpatrick DR, Fick R, Glass IA, Hulick PJ, Kline AD, Krey I, Kumar S, Lu W, Marco EJ, Wentzensen IM, Mefford HC, Platzer K, Povolotskaya IS, Savatt JM, Shcherbakova NV, Senguttuvan P, Squire AE, Stein DR, Thiffault I, Voinova VY, Somers MJG, Ferguson MA, Traum AZ, Daouk GH, Daga A, Rodig NM, Terhal PA, van Binsbergen E, Eid LA, Tasic V, Rasouly HM, Lim TY, Ahram DF, Gharavi AG, Reutter HM, Rehm HL, MacArthur DG, Lek M, Laricchia KM, Lifton RP, Xu H, Mane SM, Sanna-Cherchi S, Sharrocks AD, Raught B, Fisher SE, Bouchard M, Khokha MK, Shril S, Hildebrandt F:
Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.
Am J Hum Genet. 2020 Oct 1;107(4):727-742. doi: 10.1016/j.ajhg.2020.08.013. Epub 2020 Sep 4. PMID: 32891193

Levey AS, Eckardt KU, Dorman NM, Christiansen SL, Cheung M, Jadoul M, Winkelmayer WC:
Nomenclature for kidney function and disease: Executive summary and glossary from a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference.
J Ren Care. 2020 Sep;46(3):136. doi: 10.1111/jorc.12341. PMID: 32761852

González AM, Gutman T, Lopez-Vargas P, Anumudu S, Arce CM, Craig JC, Dunn L, Eckardt KU, Harris T, Levey AS, Lightstone L, Scholes-Robertson N, Shen JI, Teixeira-Pinto A, Wheeler DC, White D, Wilkie M, Jadoul M, Winkelmayer WC, Tong A:
Patient and Caregiver Priorities for Outcomes in CKD: A Multinational Nominal Group Technique Study.
Am J Kidney Dis. 2020 Nov;76(5):679-689. doi: 10.1053/j.ajkd.2020.03.022. Epub 2020 May 31. PMID: 32492463

Matsushita K, Jassal SK, Sang Y, Ballew SH, Grams ME, Surapaneni A, Arnlov J, Bansal N, Bozic M, Brenner H, Brunskill NJ, Chang AR, Chinnadurai R, Cirillo M, Correa A, Ebert N, Eckardt KU, Gansevoort RT, Gutierrez O, Hadaegh F, He J, Hwang SJ, Jafar TH, Kayama T, Kovesdy CP, Landman GW, Levey AS, Lloyd-Jones DM, Major RW, Miura K, Muntner P, Nadkarni GN, Naimark DM, Nowak C, Ohkubo T, Pena MJ, Polkinghorne KR, Sabanayagam C, Sairenchi T, Schneider MP, Shalev V, Shlipak M, Solbu MD, Stempniewicz N, Tollitt J, Valdivielso JM, van der Leeuw J, Wang AY, Wen CP, Woodward M, Yamagishi K, Yatsuya H, Zhang L, Schaeffner E, Coresh J:
Incorporating kidney disease measures into cardiovascular risk prediction: Development and validation in 9 million adults from 72 datasets.
EClinicalMedicine. 2020 Oct 14;27:100552. doi: 10.1016/j.eclinm.2020.100552. eCollection 2020 Oct. PMID: 33150324

Levin A, Agarwal R, Herrington WG, Heerspink HL, Mann JFE, Shahinfar S, Tuttle KR, Donner JA, Jha V, Nangaku M, de Zeeuw D, Jardine MJ, Mahaffey KW, Thompson AM, Beaucage M, Chong K, Roberts GV, Sunwold D, Vorster H, Warren M, Damster S, Malik C, Perkovic V; participant authors of the International Society of Nephrology’s 1st International Consensus Meeting on Defining Kidney Failure in Clinical Trials:
International consensus definitions of clinical trial outcomes for kidney failure: 2020.
Kidney Int. 2020 Oct;98(4):849-859. doi: 10.1016/j.kint.2020.07.013

Neumeier LI, Thomson RB, Reichel M, Eckardt KU, Aronson PS, Knauf F:
Enteric Oxalate Secretion Mediated by Slc26a6 Defends against Hyperoxalemia in Murine Models of Chronic Kidney Disease.
J Am Soc Nephrol. 2020 Sep;31(9):1987-1995. doi: 10.1681/ASN.2020010105. Epub 2020 Jul 13. PMID: 32660969

Fazzini F, Lamina C, Raschenberger J, Schultheiss UT, Kotsis F, Schönherr S, Weissensteiner H, Forer L, Steinbrenner I, Meiselbach H, Bärthlein B, Wanner C, Eckardt KU, Köttgen A, Kronenberg F; GCKD Investigators:
Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease.
Kidney Int. 2020 Aug;98(2):488-497. doi: 10.1016/j.kint.2020.02.034. Epub 2020 Apr 7. PMID: 32641227

Tong A, Levey AS, Eckardt KU, Anumudu S, Arce CM, Baumgart A, Dunn L, Gutman T, Harris T, Lightstone L, Scholes-Robertson N, Shen JI, Wheeler DC, White DM, Wilkie M, Craig JC, Jadoul M, Winkelmayer WC:
Patient and Caregiver Perspectives on Terms Used to Describe Kidney Health.
Clin J Am Soc Nephrol. 2020 Jul 1;15(7):937-948. doi: 10.2215/CJN.00900120. Epub 2020 Jun 25. PMID: 32586923

Steubl D, Schneider MP, Meiselbach H, Nadal J, Schmid MC, Saritas T, Krane V, Sommerer C, Baid-Agrawal S, Voelkl J, Kotsis F, Köttgen A, Eckardt KU, Scherberich JE; GCKD Study Investigators:
Association of Serum Uromodulin with Death, Cardiovascular Events, and Kidney Failure in CKD.
Clin J Am Soc Nephrol. 2020 May 7;15(5):616-624. doi: 10.2215/CJN.11780919. Epub 2020 Apr 14. PMID: 32291270

Xie J, Liu L, Mladkova N, Li Y, Ren H, Wang W, Cui Z, Lin L, Hu X, Yu X, Xu J, Liu G, Caliskan Y, Sidore C, Balderes O, Rosen RJ, Bodria M, Zanoni F, Zhang JY, Krithivasan P, Mehl K, Marasa M, Khan A, Ozay F, Canetta PA, Bomback AS, Appel GB, Sanna-Cherchi S, Sampson MG, Mariani LH, Perkowska-Ptasinska A, Durlik M, Mucha K, Moszczuk B, Foroncewicz B, Pączek L, Habura I, Ars E, Ballarin J, Mani LY, Vogt B, Ozturk S, Yildiz A, Seyahi N, Arikan H, Koc M, Basturk T, Karahan G, Akgul SU, Sever MS, Zhang D, Santoro D, Bonomini M, Londrino F, Gesualdo L, Reiterova J, Tesar V, Izzi C, Savoldi S, Spotti D, Marcantoni C, Messa P, Galliani M, Roccatello D, Granata S, Zaza G, Lugani F, Ghiggeri G, Pisani I, Allegri L, Sprangers B, Park JH, Cho B, Kim YS, Kim DK, Suzuki H, Amoroso A, Cattran DC, Fervenza FC, Pani A, Hamilton P, Harris S, Gupta S, Cheshire C, Dufek S, Issler N, Pepper RJ, Connolly J, Powis S, Bockenhauer D, Stanescu HC, Ashman N, Loos RJF, Kenny EE, Wuttke M, Eckardt KU, Köttgen A, Hofstra JM, Coenen MJH, Kiemeney LA, Akilesh S, Kretzler M, Beck LH, Stengel B, Debiec H, Ronco P, Wetzels JFM, Zoledziewska M, Cucca F, Ionita-Laza I, Lee H, Hoxha E, Stahl RAK, Brenchley P, Scolari F, Zhao MH, Gharavi AG, Kleta R, Chen N, Kiryluk K:
The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis.
Nat Commun. 2020 Mar 30;11(1):1600. doi: 10.1038/s41467-020-15383-w. PMID: 32231244

Schlosser P, Li Y, Sekula P, Raffler J, Grundner-Culemann F, Pietzner M, Cheng Y, Wuttke M, Steinbrenner I, Schultheiss UT, Kotsis F, Kacprowski T, Forer L, Hausknecht B, Ekici AB, Nauck M, Völker U; GCKD Investigators, Walz G, Oefner PJ, Kronenberg F, Mohney RP, Köttgen M, Suhre K, Eckardt KU, Kastenmüller G, Köttgen A:
Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans.
Nat Genet. 2020 Feb;52(2):167-176. doi: 10.1038/s41588-019-0567-8. Epub 2020 Jan 20. PMID: 31959995

Neumeier LI, Thomson RB, Reichel M, Eckardt KU, Aronson PS, Knauf F:
Enteric Oxalate Secretion Mediated by Slc26a6 Defends against Hyperoxalemia in Murine Models of Chronic Kidney Disease.
J Am Soc Nephrol. 2020 Sep;31(9):1987-1995. doi: 10.1681/ASN.2020010105. Epub 2020 Jul 13. PMID: 32660969

Levey AS, Gansevoort RT, Coresh J, Inker LA, Heerspink HL, Grams ME, Greene T, Tighiouart H, Matsushita K, Ballew SH, Sang Y, Vonesh E, Ying J, Manley T, de Zeeuw D, Eckardt KU, Levin A, Perkovic V, Zhang L, Willis K:
Change in Albuminuria and GFR as End Points for Clinical Trials in Early Stages of CKD: A Scientific Workshop Sponsored by the National Kidney Foundation in Collaboration With the US Food and Drug Administration and European Medicines Agency.
Am J Kidney Dis. 2020 Jan;75(1):84-104. doi: 10.1053/j.ajkd.2019.06.009. Epub 2019 Aug 28. PMID: 31473020

Jobst-Schwan T, Klämbt V, Tarsio M, Heneghan JF, Majmundar AJ, Shril S, Buerger F, Ottlewski I, Shmukler BE, Topaloglu R, Hashmi S, Hafeez F, Emma F, Greco M, Laube GF, Fathy HM, Pohl M, Gellermann J, Milosevic D, Baum MA, Mane S, Lifton RP, Kane PM, Alper SL, Hildebrandt F:
Whole exome sequencing identified ATP6V1C2 as a novel candidate gene for recessive distal renal tubular acidosis.
Kidney Int. 2020 Mar;97(3):567-579. doi: 10.1016/j.kint.2019.09.026. Epub 2019 Oct 22. PMID: 31959358

Vigolo E, Markó L, Hinze C, Müller DN, Schmidt-Ullrich R, Schmidt-Ott KM:
Canonical BMP signaling in tubular cells mediates recovery after acute kidney injury.
Kidney Int. 2019 Jan;95(1):108-122. doi: 10.1016/j.kint.2018.08.028. Epub 2018 Nov 15. PMID: 30447934

Sommerer C, Suwelack B, Dragun D, Schenker P, Hauser IA, Witzke O, Hugo C, Kamar N, Merville P, Junge M, Thaiss F, Nashan B; Athena Study Group:
An open-label, randomized trial indicates that everolimus with tacrolimus or cyclosporine is comparable to standard immunosuppression in de novo kidney transplant patients.
Kidney Int. 2019 Jul;96(1):231-244. doi: 10.1016/j.kint.2019.01.041. Epub 2019 Feb 27. PMID: 31027892

Lefaucheur C, Viglietti D, Bouatou Y, Philippe A, Pievani D, Aubert O, Duong Van Huyen JP, Taupin JL, Glotz D, Legendre C, Loupy A, Halloran PF, Dragun D:
Non-HLA agonistic anti-angiotensin II type 1 receptor antibodies induce a distinctive phenotype of antibody-mediated rejection in kidney transplant recipients.
Kidney Int. 2019 Jul;96(1):189-201. doi: 10.1016/j.kint.2019.01.030. Epub 2019 Mar 15. PMID: 31005275

Tang J, Wysocki J, Ye M, Vallés PG, Rein J, Shirazi M, Bader M, Gomez RA, Sequeira-Lopez MS, Afkarian M, Batlle D:
Urinary Renin in Patients and Mice With Diabetic Kidney Disease.
Hypertension. 2019 Jul;74(1):83-94. doi: 10.1161/HYPERTENSIONAHA.119.12873. Epub 2019 May 13. PMID: 31079532

Trawinski H, Karlas T, Seehofer D, Lübbert C, Halbritter J:
The Case | Atypical cysts in a patient with autosomal dominant polycystic kidney disease.
Kidney Int. 2019 Oct;96(4):1043-1044. doi: 10.1016/j.kint.2019.03.010. PMID: 31543144

Ottlewski I, Münch J, Wagner T, Schönauer R, Bachmann A, Weimann A, Hentschel J, Lindner TH, Seehofer D, Bergmann C, Jamra RA, Halbritter J:
Value of renal gene panel diagnostics in adults waiting for kidney transplantation due to undetermined end-stage renal disease.
Kidney Int. 2019 Jul;96(1):222-230. doi: 10.1016/j.kint.2019.01.038. Epub 2019 Mar 15. PMID: 31027891

Choi YJ, Halbritter J, Braun DA, Schueler M, Schapiro D, Rim JH, Nandadasa S, Choi WI, Widmeier E, Shril S, Körber F, Sethi SK, Lifton RP, Beck BB, Apte SS, Gee HY, Hildebrandt F:
Mutations of ADAMTS9 Cause Nephronophthisis-Related Ciliopathy.
Am J Hum Genet. 2019 Jan 3;104(1):45-54. doi: 10.1016/j.ajhg.2018.11.003. PMID: 30609407

Kampf LL, Schneider R, Gerstner L, Thünauer R, Chen M, Helmstädter M, Amar A, Onuchic-Whitford AC, Loza Munarriz R, Berdeli A, Müller D, Schrezenmeier E, Budde K, Mane S, Laricchia KM, Rehm HL, MacArthur DG, Lifton RP, Walz G, Römer W, Bergmann C, Hildebrandt F, Hermle T:
TBC1D8B Mutations Implicate RAB11-Dependent Vesicular Trafficking in the Pathogenesis of Nephrotic Syndrome.
J Am Soc Nephrol. 2019 Dec;30(12):2338-2353. doi: 10.1681/ASN.2019040414. Epub 2019 Nov 15. PMID: 31732614

Schrezenmeier E, Budde K, Bergmann C:
Diagnostic Utility of Exome Sequencing for Kidney Disease.
N Engl J Med. 2019 May 23;380(21):2078. doi: 10.1056/NEJMc1903250. PMID: 31116936

Xu N, Wang Q, Jiang S, Wang Q, Hu W, Zhou S, Zhao L, Xie L, Chen J, Wellstein A, Lai EY:
Fenofibrate improves vascular endothelial function and contractility in diabetic mice.
Redox Biol. 2019 Jan;20:87-97. doi: 10.1016/j.redox.2018.09.024. Epub 2018 Oct 1. PMID: 30296701

Tin A, Marten J, Halperin Kuhns VL, Li Y, Wuttke M, Kirsten H, Sieber KB, Qiu C, Gorski M, Yu Z, Giri A, Sveinbjornsson G, Li M, Chu AY, Hoppmann A, O'Connor LJ, Prins B, Nutile T, Noce D, Akiyama M, Cocca M, Ghasemi S, van der Most PJ, Horn K, Xu Y, Fuchsberger C, Sedaghat S, Afaq S, Amin N, Ärnlöv J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boerwinkle E, Bottinger EP, Boutin TS, Brumat M, Burkhardt R, Campana E, Campbell A, Campbell H, Carroll RJ, Catamo E, Chambers JC, Ciullo M, Concas MP, Coresh J, Corre T, Cusi D, Felicita SC, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Delgado G, Demirkan A, Devuyst O, Dittrich K, Eckardt KU, Ehret G, Endlich K, Evans MK, Gansevoort RT, Gasparini P, Giedraitis V, Gieger C, Girotto G, Gögele M, Gordon SD, Gudbjartsson DF, Gudnason V; German Chronic Kidney Disease Study, Haller T, Hamet P, Harris TB, Hayward C, Hicks AA, Hofer E, Holm H, Huang W, Hutri-Kähönen N, Hwang SJ, Ikram MA, Lewis RM, Ingelsson E, Jakobsdottir J, Jonsdottir I, Jonsson H, Joshi PK, Josyula NS, Jung B, Kähönen M, Kamatani Y, Kanai M, Kerr SM, Kiess W, Kleber ME, Koenig W, Kooner JS, Körner A, Kovacs P, Krämer BK, Kronenberg F, Kubo M, Kühnel B, La Bianca M, Lange LA, Lehne B, Lehtimäki T; Lifelines Cohort Study, Liu J, Loeffler M, Loos RJF, Lyytikäinen LP, Magi R, Mahajan A, Martin NG, März W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Metspalu A, Milaneschi Y; V. A. Million Veteran Program, O'Donnell CJ, Wilson OD, Gaziano JM, Mishra PP, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Müller-Nurasyid M, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O'Connell JR, Olafsson I, Padmanabhan S, Penninx BWJH, Perls T, Peters A, Pirastu M, Pirastu N, Pistis G, Polasek O, Ponte B, Porteous DJ, Poulain T, Preuss MH, Rabelink TJ, Raffield LM, Raitakari OT, Rettig R, Rheinberger M, Rice KM, Rizzi F, Robino A, Rudan I, Krajcoviechova A, Cifkova R, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Salvi E, Schmidt H, Schmidt R, Shaffer CM, Smith AV, Smith BH, Spracklen CN, Strauch K, Stumvoll M, Sulem P, Tajuddin SM, Teren A, Thiery J, Thio CHL, Thorsteinsdottir U, Toniolo D, Tönjes A, Tremblay J, Uitterlinden AG, Vaccargiu S, van der Harst P, van Duijn CM, Verweij N, Völker U, Vollenweider P, Waeber G, Waldenberger M, Whitfield JB, Wild SH, Wilson JF, Yang Q, Zhang W, Zonderman AB, Bochud M, Wilson JG, Pendergrass SA, Ho K, Parsa A, Pramstaller PP, Psaty BM, Böger CA, Snieder H, Butterworth AS, Okada Y, Edwards TL, Stefansson K, Susztak K, Scholz M, Heid IM, Hung AM, Teumer A, Pattaro C, Woodward OM, Vitart V, Köttgen A:
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
Nat Genet. 2019 Oct;51(10):1459-1474. doi: 10.1038/s41588-019-0504-x. Epub 2019 Oct 2. PMID: 31578528
https://www.nature.com/articles/s41588-019-0504-x

Giesecke T, Himmerkus N, Leipziger J, Bleich M, Koshimizu TA, Fähling M, Smorodchenko A, Shpak J, Knappe C, Isermann J, Ayasse N, Kawahara K, Schmoranzer J, Gimber N, Paliege A, Bachmann S, Mutig K:
Vasopressin Increases Urinary Acidification via V1a Receptors in Collecting Duct Intercalated Cells.
J Am Soc Nephrol. 2019 Jun;30(6):946-961. doi: 10.1681/ASN.2018080816. Epub 2019 May 16. PMID: 31097611
https://jasn.asnjournals.org/content/30/6/946

Alencar de Pinho N, Levin A, Fukagawa M, Hoy WE, Pecoits-Filho R, Reichel H, Robinson B, Kitiyakara C, Wang J, Eckardt KU, Jha V, Oh KH, Sola L, Eder S, de Borst M, Taal M, Feldman HI, Stengel B; International Network of Chronic Kidney Disease cohort studies (iNET-CKD):
Considerable international variation exists in blood pressure control and antihypertensive prescription patterns in chronic kidney disease.
Kidney Int. 2019 Oct;96(4):983-994. doi: 10.1016/j.kint.2019.04.032. Epub 2019 Jul 26. PMID: 31358344
https://www.kidney-international.org/article/S0085-2538(19)30512-5/fulltext

Devuyst O, Olinger E, Weber S, Eckardt KU, Kmoch S, Rampoldi L, Bleyer AJ:
Autosomal dominant tubulointerstitial kidney disease.
Nat Rev Dis Primers. 2019 Sep 5;5(1):60. doi: 10.1038/s41572-019-0109-9. PMID: 31488840

Fazzini F, Lamina C, Fendt L, Schultheiss UT, Kotsis F, Hicks AA, Meiselbach H, Weissensteiner H, Forer L, Krane V, Eckardt KU, Köttgen A, Kronenberg F; GCKD Investigators:
Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease.
Kidney Int. 2019 Aug;96(2):480-488. doi: 10.1016/j.kint.2019.04.021. Epub 2019 May 10. PMID: 31248648

Schley G, Klanke B, Kalucka J, Schatz V, Daniel C, Mayer M, Goppelt-Struebe M, Herrmann M, Thorsteinsdottir M, Palsson R, Beneke A, Katschinski DM, Burzlaff N, Eckardt KU, Weidemann A, Jantsch J, Willam C:
Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis.
Kidney Int. 2019 Aug;96(2):378-396. doi: 10.1016/j.kint.2019.02.016. Epub 2019 Mar 5. PMID: 31146971

Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF, Gorski M, Tin A, Wang L, Chu AY, Hoppmann A, Kirsten H, Giri A, Chai JF, Sveinbjornsson G, Tayo BO, Nutile T, Fuchsberger C, Marten J, Cocca M, Ghasemi S, Xu Y, Horn K, Noce D, van der Most PJ, Sedaghat S, Yu Z, Akiyama M, Afaq S, Ahluwalia TS, Almgren P, Amin N, Ärnlöv J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boehnke M, Boerwinkle E, Boissel M, Bottinger EP, Boutin TS, Brenner H, Brumat M, Burkhardt R, Butterworth AS, Campana E, Campbell A, Campbell H, Canouil M, Carroll RJ, Catamo E, Chambers JC, Chee ML, Chee ML, Chen X, Cheng CY, Cheng Y, Christensen K, Cifkova R, Ciullo M, Concas MP, Cook JP, Coresh J, Corre T, Sala CF, Cusi D, Danesh J, Daw EW, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Delgado G, Demirkan A, Di Angelantonio E, Dittrich K, Divers J, Dorajoo R, Eckardt KU, Ehret G, Elliott P, Endlich K, Evans MK, Felix JF, Foo VHX, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Friedlander Y, Froguel P, Gansevoort RT, Gao H, Gasparini P, Gaziano JM, Giedraitis V, Gieger C, Girotto G, Giulianini F, Gögele M, Gordon SD, Gudbjartsson DF, Gudnason V, Haller T, Hamet P, Harris TB, Hartman CA, Hayward C, Hellwege JN, Heng CK, Hicks AA, Hofer E, Huang W, Hutri-Kähönen N, Hwang SJ, Ikram MA, Indridason OS, Ingelsson E, Ising M, Jaddoe VWV, Jakobsdottir J, Jonas JB, Joshi PK, Josyula NS, Jung B, Kähönen M, Kamatani Y, Kammerer CM, Kanai M, Kastarinen M, Kerr SM, Khor CC, Kiess W, Kleber ME, Koenig W, Kooner JS, Körner A, Kovacs P, Kraja AT, Krajcoviechova A, Kramer H, Krämer BK, Kronenberg F, Kubo M, Kühnel B, Kuokkanen M, Kuusisto J, La Bianca M, Laakso M, Lange LA, Langefeld CD, Lee JJ, Lehne B, Lehtimäki T, Lieb W; Lifelines Cohort Study, Lim SC, Lind L, Lindgren CM, Liu J, Liu J, Loeffler M, Loos RJF, Lucae S, Lukas MA, Lyytikäinen LP, Mägi R, Magnusson PKE, Mahajan A, Martin NG, Martins J, März W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Melander O, Metspalu A, Mikaelsdottir EK, Milaneschi Y, Miliku K, Mishra PP; V. A. Million Veteran Program, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Mychaleckyj JC, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O'Connell J, O'Donoghue ML, Olafsson I, Oldehinkel AJ, Orho-Melander M, Ouwehand WH, Padmanabhan S, Palmer ND, Palsson R, Penninx BWJH, Perls T, Perola M, Pirastu M, Pirastu N, Pistis G, Podgornaia AI, Polasek O, Ponte B, Porteous DJ, Poulain T, Pramstaller PP, Preuss MH, Prins BP, Province MA, Rabelink TJ, Raffield LM, Raitakari OT, Reilly DF, Rettig R, Rheinberger M, Rice KM, Ridker PM, Rivadeneira F, Rizzi F, Roberts DJ, Robino A, Rossing P, Rudan I, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Sabanayagam C, Salomaa V, Salvi E, Saum KU, Schmidt H, Schmidt R, Schöttker B, Schulz CA, Schupf N, Shaffer CM, Shi Y, Smith AV, Smith BH, Soranzo N, Spracklen CN, Strauch K, Stringham HM, Stumvoll M, Svensson PO, Szymczak S, Tai ES, Tajuddin SM, Tan NYQ, Taylor KD, Teren A, Tham YC, Thiery J, Thio CHL, Thomsen H, Thorleifsson G, Toniolo D, Tönjes A, Tremblay J, Tzoulaki I, Uitterlinden AG, Vaccargiu S, van Dam RM, van der Harst P, van Duijn CM, Velez Edward DR, Verweij N, Vogelezang S, Völker U, Vollenweider P, Waeber G, Waldenberger M, Wallentin L, Wang YX, Wang C, Waterworth DM, Bin Wei W, White H, Whitfield JB, Wild SH, Wilson JF, Wojczynski MK, Wong C, Wong TY, Xu L, Yang Q, Yasuda M, Yerges-Armstrong LM, Zhang W, Zonderman AB, Rotter JI, Bochud M, Psaty BM, Vitart V, Wilson JG, Dehghan A, Parsa A, Chasman DI, Ho K, Morris AP, Devuyst O, Akilesh S, Pendergrass SA, Sim X, Böger CA, Okada Y, Edwards TL, Snieder H, Stefansson K, Hung AM, Heid IM, Scholz M, Teumer A, Köttgen A, Pattaro C:
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
Nat Genet. 2019 Jun;51(6):957-972. doi: 10.1038/s41588-019-0407-x. Epub 2019 May 31.PMID: 31152163

Rondeau E, Luyckx VA, Anders HJ, Eckardt KU, Florquin S, Marti HP, Ølgaard K, Harden P; members of the Western Europe Regional Board, International Society of Nephrology:
Challenges and opportunities for nephrology in Western Europe.
Kidney Int. 2019 May;95(5):1037-1040. doi: 10.1016/j.kint.2018.09.028. Epub 2019 Feb 16. PMID: 30777285

Hammer F, Malzahn U, Donhauser J, Betz C, Schneider MP, Grupp C, Pollak N, Störk S, Wanner C, Krane V; MiREnDa Study Group:
A randomized controlled trial of the effect of spironolactone on left ventricular mass in hemodialysis patients.
Kidney Int. 2019 Apr;95(4):983-991. doi: 10.1016/j.kint.2018.11.025. Epub 2019 Jan 31. PMID: 30712923

Mc Causland FR, Claggett B, Burdmann EA, Chertow GM, Cooper ME, Eckardt KU, Ivanovich P, Levey AS, Lewis EF, McGill JB, McMurray JJV, Parfrey P, Parving HH, Remuzzi G, Singh AK, Solomon SD, Toto RD, Pfeffer MA:
Treatment of Anemia With Darbepoetin Prior to Dialysis Initiation and Clinical Outcomes: Analyses From the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT).
Am J Kidney Dis. 2019 Mar;73(3):309-315. doi: 10.1053/j.ajkd.2018.10.006. Epub 2018 Dec 19. PMID: 30578152

Coresh J, Heerspink HJL, Sang Y, Matsushita K, Arnlov J, Astor BC, Black C, Brunskill NJ, Carrero JJ, Feldman HI, Fox CS, Inker LA, Ishani A, Ito S, Jassal S, Konta T, Polkinghorne K, Romundstad S, Solbu MD, Stempniewicz N, Stengel B, Tonelli M, Umesawa M, Waikar SS, Wen CP, Wetzels JFM, Woodward M, Grams ME, Kovesdy CP, Levey AS, Gansevoort RT; Chronic Kidney Disease Prognosis Consortium and Chronic Kidney Disease Epidemiology Collaboration:
Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies.
Lancet Diabetes Endocrinol. 2019 Feb;7(2):115-127. doi: 10.1016/S2213-8587(18)30313-9. Epub 2019 Jan 8. PMID: 30635225

Inker LA, Grams ME, Levey AS, Coresh J, Cirillo M, Collins JF, Gansevoort RT, Gutierrez OM, Hamano T, Heine GH, Ishikawa S, Jee SH, Kronenberg F, Landray MJ, Miura K, Nadkarni GN, Peralta CA, Rothenbacher D, Schaeffner E, Sedaghat S, Shlipak MG, Zhang L, van Zuilen AD, Hallan SI, Kovesdy CP, Woodward M, Levin A; CKD Prognosis Consortium:
Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium.
Am J Kidney Dis. 2019 Feb;73(2):206-217. doi: 10.1053/j.ajkd.2018.08.013. Epub 2018 Oct 19. PMID: 30348535

Chang AR, Grams ME, Ballew SH, Bilo H, Correa A, Evans M, Gutierrez OM, Hosseinpanah F, Iseki K, Kenealy T, Klein B, Kronenberg F, Lee BJ, Li Y, Miura K, Navaneethan SD, Roderick PJ, Valdivielso JM, Visseren FLJ, Zhang L, Gansevoort RT, Hallan SI, Levey AS, Matsushita K, Shalev V, Woodward M; CKD Prognosis Consortium (CKD-PC):
Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.
BMJ. 2019 Jan 10;364:k5301. doi: 10.1136/bmj.k5301. PMID: 30630856

Knauf F, Brewer JR, Flavell RA:
Immunity, microbiota and kidney disease.
Nat Rev Nephrol. 2019 May;15(5):263-274. doi: 10.1038/s41581-019-0118-7. PMID: 30796361

Egli-Spichtig D, Imenez Silva PH, Glaudemans B, Gehring N, Bettoni C, Zhang MYH, Pastor-Arroyo EM, Schönenberger D, Rajski M, Hoogewijs D, Knauf F, Misselwitz B, Frey-Wagner I, Rogler G, Ackermann D, Ponte B, Pruijm M, Leichtle A, Fiedler GM, Bochud M, Ballotta V, Hofmann S, Perwad F, Föller M, Lang F, Wenger RH, Frew I, Wagner CA:
Tumor necrosis factor stimulates fibroblast growth factor 23 levels in chronic kidney disease and non-renal inflammation.
Kidney Int. 2019 Oct;96(4):890-905. doi: 10.1016/j.kint.2019.04.009. Epub 2019 May 14. PMID: 31301888

Schrezenmeier E, Sattler A, Halleck F, Budde K:
Authors' Reply: SARS-CoV-2 Vaccination in Kidney Transplant Recipients: Should We Consider Intradermal Vaccination? 
J Am Soc Nephrol. 2022 Feb 14:ASN.2022010033. doi: 10.1681/ASN.2022010033. Online ahead of print. PMID: 35165122 

Stockmann H, Thelen P, Stroben F, Pigorsch M, Keller T, Krannich A, Spies C, Treskatsch S, Ocken M, Kunz JV, Krüger A, Khadzhynov D, Kron S, Budde K, Eckardt KU, Enghard P, Lehner LJ:
CytoSorb Rescue for COVID-19 Patients With Vasoplegic Shock and Multiple Organ Failure: A Prospective, Open-Label, Randomized Controlled Pilot Study. 
Crit Care Med. 2022 Feb 9. doi: 10.1097/CCM.0000000000005493. Online ahead of print. PMID: 35135967

Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B; PA-COVID-19 Study Group:
Complement activation induces excessive T cell cytotoxicity in severe COVID-19. 
Cell. 2022 Feb 3;185(3):493-512.e25. doi: 10.1016/j.cell.2021.12.040. PMID: 35032429  

Khadzhynov D, von dem Berge U, Muench F, Karaivanov S, Koerner R, Kruse JM, Zickler D, Budde K, Eckardt KU, Lehner LJ:
Efficacy and complications of regional citrate anticoagulation during continuous renal replacement therapy in critically ill patients with COVID-19. 
J Crit Care. 2022 Feb;67:126-131. doi: 10.1016/j.jcrc.2021.10.010. PMID: 34768173

Wojciechowska W, Januszewicz A, Drożdż T, Rojek M, Bączalska J, Terlecki M, Kurasz K, Olszanecka A, Smólski M, Prejbisz A, Dobrowolski P, Grodzicki T, Hryniewiecki T, Kreutz R, Rajzer M:
Blood Pressure and Arterial Stiffness in Association With Aircraft Noise Exposure:Long-Term Observation and Potential Effect of COVID-19 Lockdown. 
Hypertension. 2022 Feb;79(2):325-334. doi: 10.1161/HYPERTENSIONAHA.121.17704. PMID: 34657440

Rincon-Arevalo H, Aue A, Ritter J, Szelinski F, Khadzhynov D, Zickler D, Stefanski L, Lino AC, Körper S, Eckardt KU, Schrezenmeier H, Dörner T, Schrezenmeier EV:
Altered increase in STAT1 expression and phosphorylation in severe COVID-19. 
Eur J Immunol. 2022 Jan;52(1):138-148. doi: 10.1002/eji.202149575. PMID: 34676541 Clinical Trial.

Seidel D, Simon M, Sprute R, Lubnow M, Evert K, Speer C, Seeßle J, Khatamzas E, Merle U, Behrens C, Blau IW, Enghard P, Haas CS, Steinmann J, Kurzai O, Cornely OA:
Results from a national survey on COVID-19-associated mucormycosis in Germany: 13 patients from six tertiary hospitals. 
Mycoses. 2022 Jan;65(1):103-109. doi: 10.1111/myc.13379. PMID: 34655486

Enghard P, Hardenberg JH, Stockmann H, Hinze C, Eckardt KU, Schmidt-Ott KM:
Long-term effects of COVID-19 on kidney function.
Lancet. 2021 May 15;397(10287):1806-1807. doi: 10.1016/S0140-6736(21)00880-1. PMID: 33992141

Mühlemann B, Thibeault C, Hillus D, Helbig ET, Lippert LJ, Tober-Lau P, Schwarz T, Müller MA; Pa-COVID-19 collaborative study group, Witzenrath M, Suttorp N, Sander LE, Drosten C, Jones TC, Corman VM, Kurth F:
Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study.
Clin Microbiol Infect. 2021 Oct;27(10):1520.e7-1520.e10. doi: 10.1016/j.cmi.2021.06.008. Epub 2021 Jun 15. PMID: 34139335

Theobald SJ, Simonis A, Georgomanolis T, Kreer C, Zehner M, Eisfeld HS, Albert MC, Chhen J, Motameny S, Erger F, Fischer J, Malin JJ, Gräb J, Winter S, Pouikli A, David F, Böll B, Koehler P, Vanshylla K, Gruell H, Suárez I, Hallek M, Fätkenheuer G, Jung N, Cornely OA, Lehmann C, Tessarz P, Altmüller J, Nürnberg P, Kashkar H, Klein F, Koch M, Rybniker J:
Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19.
EMBO Mol Med. 2021 Aug 9;13(8):e14150. doi: 10.15252/emmm.202114150. Epub 2021 Jun 16. PMID: 34133077

Stefanski AL, Rincon-Arevalo H, Schrezenmeier E, Karberg K, Szelinski F, Ritter J, Jahrsdörfer B, Schrezenmeier H, Ludwig C, Sattler A, Kotsch K, Chen Y, Claußnitzer A, Haibel H, Proft F, Guerra G, Durek P, Heinrich F, Ferreira-Gomes M, Burmester GR, Radbruch A, Mashreghi MF, Lino AC, Dörner T:
B cell numbers predict humoral and cellular response upon SARS-CoV-2 vaccination among patients treated with rituximab. 
Arthritis Rheumatol. 2021 Dec 28. doi: 10.1002/art.42060. Online ahead of print. PMID: 34962360

Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE:
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis. 
Cell. 2021 Dec 22;184(26):6243-6261.e27. doi: 10.1016/j.cell.2021.11.033. PMID: 34914922

Osmanodja B, Schreiber A, Schrezenmeier E, Seelow E:
First diagnosis of thrombotic thrombocytopenic purpura after SARS-CoV-2 vaccine - case report. 
BMC Nephrol. 2021 Dec 11;22(1):411. doi: 10.1186/s12882-021-02616-3. PMID: 34895163

Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, McEwen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A:
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells. 
Nature. 2021 Dec;600(7888):295-301. doi: 10.1038/s41586-021-04142-6. PMID: 34695836

Bekassy Z, Lopatko Fagerström I, Bader M, Karpman D:
Crosstalk between the renin-angiotensin, complement and kallikrein-kinin systems in inflammation. 
Nat Rev Immunol. 2021 Nov 10:1-18. doi: 10.1038/s41577-021-00634-8. Online ahead of print. PMID: 34759348 Review.

Krämer B, Knoll R, Bonaguro L, ToVinh M, Raabe J, Astaburuaga-García R, Schulte-Schrepping J, Kaiser KM, Rieke GJ, Bischoff J, Monin MB, Hoffmeister C, Schlabe S, De Domenico E, Reusch N, Händler K, Reynolds G, Blüthgen N, Hack G, Finnemann C, Nischalke HD, Strassburg CP, Stephenson E, Su Y, Gardner L, Yuan D, Chen D, Goldman J, Rosenstiel P, Schmidt SV, Latz E, Hrusovsky K, Ball AJ, Johnson JM, Koenig PA, Schmidt FI, Haniffa M, Heath JR, Kümmerer BM, Keitel V, Jensen B, Stubbemann P, Kurth F, Sander LE, Sawitzki B; Deutsche COVID-19 OMICS Initiative (DeCOI), Aschenbrenner AC, Schultze JL, Nattermann J:
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19. 
Immunity. 2021 Nov 9;54(11):2650-2669.e14. doi: 10.1016/j.immuni.2021.09.002. PMID: 34592166

Schrezenmeier E, Rincon-Arevalo H, Stefanski AL, Potekhin A, Straub-Hohenbleicher H, Choi M, Bachmann F, Pross V, Hammett C, Schrezenmeier H, Ludwig C, Jahrsdörfer B, Lino A, Eckardt KU, Kotsch K, Döerner T, Budde K, Sattler A, Halleck F:
B and T Cell Responses after a Third Dose of SARS-CoV-2 Vaccine in Kidney Transplant Recipients. 
J Am Soc Nephrol. 2021 Oct 19;32(12):3027-33. doi: 10.1681/ASN.2021070966. PMID: 34667083

Körper S, Weiss M, Zickler D, Wiesmann T, Zacharowski K, Corman VM, Grüner B, Ernst L, Spieth P, Lepper PM, Bentz M, Zinn S, Paul G, Kalbhenn J, Dollinger MM, Rosenberger P, Kirschning T, Thiele T, Appl T, Mayer B, Schmidt M, Drosten C, Wulf H, Kruse JM, Jungwirth B, Seifried E, Schrezenmeier H; CAPSID Clinical Trial Group:
Results of the CAPSID randomized trial for high-dose convalescent plasma in patients with severe COVID-19. 
J Clin Invest. 2021 Oct 15;131(20):e152264. doi: 10.1172/JCI152264. PMID: 34464358 Clinical Trial.

Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U, Kern F, Schwarz T, Mangold M, Unger C, Dörfler F, Kadler S, Rosowski J, Gürcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Müller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE, Corman VM, Röhmel J, Meyer-Arndt L, Thiel A, Giesecke-Thiel C:
Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination. 
Science. 2021 Oct 8;374(6564):eabh1823. doi: 10.1126/science.abh1823. PMID: 34465633

Loske J, Röhmel J, Lukassen S, Stricker S, Magalhães VG, Liebig J, Chua RL, Thürmann L, Messingschlager M, Seegebarth A, Timmermann B, Klages S, Ralser M, Sawitzki B, Sander LE, Corman VM, Conrad C, Laudi S, Binder M, Trump S, Eils R, Mall MA, Lehmann I:
Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children. 
Nat Biotechnol. 2021 Aug 18. doi: 10.1038/s41587-021-01037-9. Online ahead of print. PMID: 34408314

Demichev V, Tober-Lau P, Lemke O, Nazarenko T, Thibeault C, Whitwell H, Röhl A, Freiwald A, Szyrwiel L, Ludwig D, Correia-Melo C, Aulakh SK, Helbig ET, Stubbemann P, Lippert LJ, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Mittermaier M, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Enghard P, Zelezniak A, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Müller-Redetzky H, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group, Ralser M, Kurth F:
A time-resolved proteomic and prognostic map of COVID-19. 
Cell Syst. 2021 Aug 18;12(8):780-794.e7. doi: 10.1016/j.cels.2021.05.005. PMID: 34139154

Nouailles G, Wyler E, Pennitz P, Postmus D, Vladimirova D, Kazmierski J, Pott F, Dietert K, Muelleder M, Farztdinov V, Obermayer B, Wienhold SM, Andreotti S, Hoefler T, Sawitzki B, Drosten C, Sander LE, Suttorp N, Ralser M, Beule D, Gruber AD, Goffinet C, Landthaler M, Trimpert J, Witzenrath M:
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19. 
Nat Commun. 2021 Aug 11;12(1):4869. doi: 10.1038/s41467-021-25030-7. PMID: 34381043

Kruse JM, Zickler D, Lüdemann WM, Piper SK, Gotthardt I, Ihlow J, Greuel S, Horst D, Kahl A, Eckardt KU, Elezkurtaj S:
Evidence for a thromboembolic pathogenesis of lung cavitations in severely ill COVID-19 patients. 
Sci Rep. 2021 Aug 6;11(1):16039. doi: 10.1038/s41598-021-95694-0. PMID: 34362979  

Sattler A, Schrezenmeier E, Weber UA, Potekhin A, Bachmann F, Straub-Hohenbleicher H, Budde K, Storz E, Proß V, Bergmann Y, Thole LM, Tizian C, Hölsken O, Diefenbach A, Schrezenmeier H, Jahrsdörfer B, Zemojtel T, Jechow K, Conrad C, Lukassen S, Stauch D, Lachmann N, Choi M, Halleck F, Kotsch K:
Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients. 
J Clin Invest. 2021 Jul 15;131(14):e150175. doi: 10.1172/JCI150175. PMID: 34101623

Schrezenmeier E, Bergfeld L, Hillus D, Lippert JD, Weber U, Tober-Lau P, Landgraf I, Schwarz T, Kappert K, Stefanski AL, Sattler A, Kotsch K, Dörner T, Sander LE, Budde K, Halleck F, Kurth F, Corman VM, Choi M:
Immunogenicity of COVID-19 Tozinameran Vaccination in Patients on Chronic Dialysis. 
Front Immunol. 2021 Jun 30;12:690698. doi: 10.3389/fimmu.2021.690698. eCollection 2021. PMID: 34276681

Magomedov A, Zickler D, Karaivanov S, Kurreck A, Münch FH, Kamhieh-Milz J, Ferse C, Kahl A, Piper SK, Eckardt KU, Dörner T, Kruse JM:
Viscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-19. 
Sci Rep. 2021 Jun 25;11(1):13325. doi: 10.1038/s41598-021-92683-1. PMID: 34172793

Rincon-Arevalo H, Choi M, Stefanski AL, Halleck F, Weber U, Szelinski F, Jahrsdörfer B, Schrezenmeier H, Ludwig C, Sattler A, Kotsch K, Potekhin A, Chen Y, Burmester GR, Eckardt KU, Guerra GM, Durek P, Heinrich F, Ferreira-Gomes M, Radbruch A, Budde K, Lino AC, Mashreghi MF, Schrezenmeier E, Dörner T:
Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients. 
Sci Immunol. 2021 Jun 15;6(60):eabj1031. doi: 10.1126/sciimmunol.abj1031. PMID: 34131023

Roussel M, Ferrant J, Reizine F, Le Gallou S, Dulong J, Carl S, Lesouhaitier M, Gregoire M, Bescher N, Verdy C, Latour M, Bézier I, Cornic M, Vinit A, Monvoisin C, Sawitzki B, Leonard S, Paul S, Feuillard J, Jeannet R, Daix T, Tiwari VK, Tadié JM, Cogné M, Tarte K:
Comparative immune profiling of acute respiratory distress syndrome patients with or without SARS-CoV-2 infection. 
Cell Rep Med. 2021 Jun 15;2(6):100291. doi: 10.1016/j.xcrm.2021.100291. PMID: 33977279

Kreutz R, Dobrowolski P, Prejbisz A, Algharably EAE, Bilo G, Creutzig F, Grassi G, Kotsis V, Lovic D, Lurbe E, Modesti PA, Pappaccogli M, Parati G, Persu A, Polonia J, Rajzer M, de Timary P, Weber T, Weisser B, Tsioufis K, Mancia G, Januszewicz A; European Society of Hypertension COVID-19 Task Force Review:
Lifestyle, psychological, socioeconomic and environmental factors and their impact on hypertension during the coronavirus disease 2019 pandemic. 
J Hypertens. 2021 Jun 1;39(6):1077-1089. doi: 10.1097/HJH.0000000000002770. PMID: 33395152 Review.

Lerchbaumer MH, Lauryn JH, Bachmann U, Enghard P, Fischer T, Grune J, Hegemann N, Khadzhynov D, Kruse JM, Lehner LJ, Lindner T, Oezkan T, Zickler D, Kuebler WM, Hamm B, Eckardt KU, Muench F:
Point-of-care lung ultrasound in COVID-19 patients: inter- and intra-observer agreement in a prospective observational study. 
Sci Rep. 2021 May 21;11(1):10678. doi: 10.1038/s41598-021-90153-2. PMID: 34021219 Clinical Trial.

Ochs M, Timm S, Elezkurtaj S, Horst D, Meinhardt J, Heppner FL, Weber-Carstens S, Hocke AC, Witzenrath M:
Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient. 
Eur Respir J. 2021 May 6;57(5):2004165. doi: 10.1183/13993003.04165-2020. PMID: 33446606

Savoia C, Volpe M, Kreutz R:
Hypertension, a Moving Target in COVID-19: Current Views and Perspectives. 
Circ Res. 2021 Apr 2;128(7):1062-1079. doi: 10.1161/CIRCRESAHA.121.318054. PMID: 33793331 Review.

Hardenberg JB, Stockmann H, Aigner A, Gotthardt I, Enghard P, Hinze C, Balzer F, Schmidt D, Zickler D, Kruse J, Körner R, Stegemann M, Schneider T, Schumann M, Müller-Redetzky H, Angermair S, Budde K, Weber-Carstens S, Witzenrath M, Treskatsch S, Siegmund B, Spies C, Suttorp N, Rauch G, Eckardt KU, Schmidt-Ott KM:
Critical Illness and Systemic Inflammation Are Key Risk Factors of Severe Acute Kidney Injury in Patients With COVID-19. 
Kidney Int Rep. 2021 Apr;6(4):905-915. doi: 10.1016/j.ekir.2021.01.011. PMID: 33817450

Stockmann H, Hardenberg JB, Aigner A, Hinze C, Gotthardt I, Stier B, Eckardt KU, Schmidt-Ott KM, Enghard P:
High rates of long-term renal recovery in survivors of coronavirus disease 2019-associated acute kidney injury requiring kidney replacement therapy. 
Kidney Int. 2021 Apr;99(4):1021-1022. doi: 10.1016/j.kint.2021.01.005. PMID: 33515574

Franke C, Ferse C, Kreye J, Reincke SM, Sanchez-Sendin E, Rocco A, Steinbrenner M, Angermair S, Treskatsch S, Zickler D, Eckardt KU, Dersch R, Hosp J, Audebert HJ, Endres M, Ploner JC, Prüß H:
High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms. 
Brain Behav Immun. 2021 Mar;93:415-419. doi: 10.1016/j.bbi.2020.12.022. PMID: 33359380

Franke C, Ferse C, Kreye J, Reincke SM, Sanchez-Sendin E, Rocco A, Steinbrenner M, Angermair S, Treskatsch S, Zickler D, Eckardt KU, Dersch R, Hosp J, Audebert HJ, Endres M, Ploner JC, Prüß H:
High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms.
Brain Behav Immun. 2021 Mar;93:415-419. doi: 10.1016/j.bbi.2020.12.022. Epub 2020 Dec 24. PMID: 33359380

Bader M, Turner AJ, Alenina N:
ACE2, a multifunctional protein - from cardiovascular regulation to COVID-19. 
Clin Sci (Lond). 2020 Dec 11;134(23):3229-3232. doi: 10.1042/CS20201493. PMID: 33305790

Kruse JM, Magomedov A, Kurreck A, Münch FH, Koerner R, Kamhieh-Milz J, Kahl A, Gotthardt I, Piper SK, Eckardt KU, Dörner T, Zickler D:
Thromboembolic complications in critically ill COVID-19 patients are associated with impaired fibrinolysis. 
Crit Care. 2020 Dec 7;24(1):676. doi: 10.1186/s13054-020-03401-8. PMID: 33287877

Sattler A, Angermair S, Stockmann H, Heim KM, Khadzhynov D, Treskatsch S, Halleck F, Kreis ME, Kotsch K:
SARS-CoV-2-specific T cell responses and correlations with COVID-19 patient predisposition. 
J Clin Invest. 2020 Dec 1;130(12):6477-6489. doi: 10.1172/JCI140965. PMID: 32833687 Clinical Trial.

Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk HD, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba AE, Sander LE; Deutsche COVID-19 OMICS Initiative (DeCOI):
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. 
Cell. 2020 Sep 17;182(6):1419-1440.e23. doi: 10.1016/j.cell.2020.08.001. PMID: 32810438

Schrezenmeier EV, Burmester GR, Eckardt KU, Dörner T:
Role for antimalarials in the management of COVID-19. 
Curr Opin Rheumatol. 2020 Sep;32(5):449-457. doi: 10.1097/BOR.0000000000000731. PMID: 32675717 Review.

Kurth F, Roennefarth M, Thibeault C, Corman VM, Müller-Redetzky H, Mittermaier M, Ruwwe-Glösenkamp C, Heim KM, Krannich A, Zvorc S, Schmidt S, Kretzler L, Dang-Heine C, Rose M, Hummel M, Hocke A, Hübner RH, Opitz B, Mall MA, Röhmel J, Landmesser U, Pieske B, Knauss S, Endres M, Spranger J, Mockenhaupt FP, Tacke F, Treskatsch S, Angermair S, Siegmund B, Spies C, Weber-Carstens S, Eckardt KU, Schürmann D, Uhrig A, Stegemann MS, Zoller T, Drosten C, Suttorp N, Witzenrath M, Hippenstiel S, von Kalle C, Sander LE:
Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19). 
Infection. 2020 Aug;48(4):619-626. doi: 10.1007/s15010-020-01464-x. PMID: 32535877

Guzik TJ, Mohiddin SA, Dimarco A, Patel V, Savvatis K, Marelli-Berg FM, Madhur MS, Tomaszewski M, Maffia P, D'Acquisto F, Nicklin SA, Marian AJ, Nosalski R, Murray EC, Guzik B, Berry C, Touyz RM, Kreutz R, Wang DW, Bhella D, Sagliocco O, Crea F, Thomson EC, McInnes IB:
COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. 
Cardiovasc Res. 2020 Aug 1;116(10):1666-1687. doi: 10.1093/cvr/cvaa106. PMID: 32352535

Kreutz R, Algharably EAE, Azizi M, Dobrowolski P, Guzik T, Januszewicz A, Persu A, Prejbisz A, Riemer TG, Wang JG, Burnier M:
Hypertension, the renin-angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19. 
Cardiovasc Res. 2020 Aug 1;116(10):1688-1699. doi: 10.1093/cvr/cvaa097. PMID: 32293003

Stockmann H, Keller T, Büttner S, Jörres A, Kindgen-Milles D, Kunz JV, Leebmann J, Spies C, Träger K, Treskatsch S, Uhrig A, Willam C, Enghard P, Slowinski T; CytoResc Trial Investigators:
CytoResc - "CytoSorb" Rescue for critically ill patients undergoing the COVID-19 Cytokine Storm: A structured summary of a study protocol for a randomized controlled trial. 
Trials. 2020 Jun 26;21(1):577. doi: 10.1186/s13063-020-04501-0. PMID: 32586396 Clinical Trial

Zeziulia M, Blin S, Schmitt FW, Lehmann M, Jentsch TJ:
Proton-gated anion transport governs macropinosome shrinkage.
Nat Cell Biol. 2022 Jun;24(6):885-895. doi: 10.1038/s41556-022-00912-0. Epub 2022 May 19. PMID: 35590106

Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, Kitajima H, Yu GZ, Rüeger S, Speidel L, Kim YJ, Horikoshi M, Mercader JM, Taliun D, Moon S, Kwak SH, Robertson NR, Rayner NW, Loh M, Kim BJ, Chiou J, Miguel-Escalada I, Della Briotta Parolo P, Lin K, Bragg F, Preuss MH, Takeuchi F, Nano J, Guo X, Lamri A, Nakatochi M, Scott RA, Lee JJ, Huerta-Chagoya A, Graff M, Chai JF, Parra EJ, Yao J, Bielak LF, Tabara Y, Hai Y, Steinthorsdottir V, Cook JP, Kals M, Grarup N, Schmidt EM, Pan I, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Long J, Sun M, Tong L, Chen WM, Ahmad M, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Lecoeur C, Prins BP, Nicolas A, Yanek LR, Chen G, Jensen RA, Tajuddin S, Kabagambe EK, An P, Xiang AH, Choi HS, Cade BE, Tan J, Flanagan J, Abaitua F, Adair LS, Adeyemo A, Aguilar-Salinas CA, Akiyama M, Anand SS, Bertoni A, Bian Z, Bork-Jensen J, Brandslund I, Brody JA, Brummett CM, Buchanan TA, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Fornage M, Franco OH, Frayling TM, Freedman BI, Fuchsberger C, Genter P, Gerstein HC, Giedraitis V, González-Villalpando C, González-Villalpando ME, Goodarzi MO, Gordon-Larsen P, Gorkin D, Gross M, Guo Y, Hackinger S, Han S, Hattersley AT, Herder C, Howard AG, Hsueh W, Huang M, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang HM, Jasmine F, Jiang G, Jonas JB, Jørgensen ME, Jørgensen T, Kamatani Y, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya MG, Kim DH, Kohara K, Kriebel J, Kronenberg F, Kuusisto J, Läll K, Lange LA, Lee MS, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu CT, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lyssenko V, Mamakou V, Mani KR, Meitinger T, Metspalu A, Morris AD, Nadkarni GN, Nadler JL, Nalls MA, Nayak U, Nongmaithem SS, Ntalla I, Okada Y, Orozco L, Patel SR, Pereira MA, Peters A, Pirie FJ, Porneala B, Prasad G, Preissl S, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sander M, Sandow K, Sattar N, Schönherr S, Schurmann C, Shahriar M, Shi J, Shin DM, Shriner D, Smith JA, So WY, Stančáková A, Stilp AM, Strauch K, Suzuki K, Takahashi A, Taylor KD, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tomlinson B, Torres JM, Tsai FJ, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Vujkovic M, Wacher-Rodarte N, Wheeler E, Whitsel EA, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamauchi T, Yengo L, Yoon K, Yu C, Yuan JM, Yusuf S, Zhang L, Zheng W; FinnGen; eMERGE Consortium, Raffel LJ, Igase M, Ipp E, Redline S, Cho YS, Lind L, Province MA, Hanis CL, Peyser PA, Ingelsson E, Zonderman AB, Psaty BM, Wang YX, Rotimi CN, Becker DM, Matsuda F, Liu Y, Zeggini E, Yokota M, Rich SS, Kooperberg C, Pankow JS, Engert JC, Chen YI, Froguel P, Wilson JG, Sheu WHH, Kardia SLR, Wu JY, Hayes MG, Ma RCW, Wong TY, Groop L, Mook-Kanamori DO, Chandak GR, Collins FS, Bharadwaj D, Paré G, Sale MM, Ahsan H, Motala AA, Shu XO, Park KS, Jukema JW, Cruz M, McKean-Cowdin R, Grallert H, Cheng CY, Bottinger EP, Dehghan A, Tai ES, Dupuis J, Kato N, Laakso M, Köttgen A, Koh WP, Palmer CNA, Liu S, Abecasis G, Kooner JS, Loos RJF, North KE, Haiman CA, Florez JC, Saleheen D, Hansen T, Pedersen O, Mägi R, Langenberg C, Wareham NJ, Maeda S, Kadowaki T, Lee J, Millwood IY, Walters RG, Stefansson K, Myers SR, Ferrer J, Gaulton KJ, Meigs JB, Mohlke KL, Gloyn AL, Bowden DW, Below JE, Chambers JC, Sim X, Boehnke M, Rotter JI, McCarthy MI, Morris AP:
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.
Nat Genet. 2022 May;54(5):560-572. doi: 10.1038/s41588-022-01058-3. Epub 2022 May 12. PMID: 35551307

Nemec K, Schihada H, Kleinau G, Zabel U, Grushevskyi EO, Scheerer P, Lohse MJ, Maiellaro I:
Functional modulation of PTH1R activation and signaling by RAMP2.
Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2122037119. doi: 10.1073/pnas.2122037119. Epub 2022 Aug 1. PMID: 35914163

Yang Y, Stensitzki T, Sauthof L, Schmidt A, Piwowarski P, Velazquez Escobar F, Michael N, Nguyen AD, Szczepek M, Brünig FN, Netz RR, Mroginski MA, Adam S, Bartl F, Schapiro I, Hildebrandt P, Scheerer P, Heyne K:
Ultrafast proton-coupled isomerization in the phototransformation of phytochrome.
Nat Chem. 2022 Jul;14(7):823-830. doi: 10.1038/s41557-022-00944-x. Epub 2022 May 16. PMID: 35577919

Ye Q, Lan B, Liu H, Persson PB, Lai EY, Mao J:
A critical role of the podocyte cytoskeleton in the pathogenesis of glomerular proteinuria and autoimmune podocytopathies.
Acta Physiol 2022 Jun 18:e13850. Doi: 10.1111/apha.13850. PMID: 35716094 

Ye Q, Chen A, Lai EY, Mao J:
Autoimmune Podocytopathies: A Novel Sub-Group of Diseases from Childhood Idiopathic Nephrotic Syndrome.
J Am Soc Nephrol. 2022 Mar;33(3):653-654. doi: 10.1681/ASN.2021111469. Epub 2022 Jan 21. PMID: 35064050

Fromentin S, Forslund SK, Chechi K, Aron-Wisnewsky J, Chakaroun R, Nielsen T, Tremaroli V, Ji B, Prifti E, Myridakis A, Chilloux J, Andrikopoulos P, Fan Y, Olanipekun MT, Alves R, Adiouch S, Bar N, Talmor-Barkan Y, Belda E, Caesar R, Coelho LP, Falony G, Fellahi S, Galan P, Galleron N, Helft G, Hoyles L, Isnard R, Le Chatelier E, Julienne H, Olsson L, Pedersen HK, Pons N, Quinquis B, Rouault C, Roume H, Salem JE, Schmidt TSB, Vieira-Silva S, Li P, Zimmermann-Kogadeeva M, Lewinter C, Søndertoft NB, Hansen TH, Gauguier D, Gøtze JP, Køber L, Kornowski R, Vestergaard H, Hansen T, Zucker JD, Hercberg S, Letunic I, Bäckhed F, Oppert JM, Nielsen J, Raes J, Bork P, Stumvoll M, Segal E, Clément K, Dumas ME, Ehrlich SD, Pedersen O:
Microbiome and metabolome features of the cardiometabolic disease spectrum.
Nat Med. 2022 Feb;28(2):303-314. doi: 10.1038/s41591-022-01688-4. Epub 2022 Feb 17. PMID: 35177860

Talmor-Barkan Y, Bar N, Shaul AA, Shahaf N, Godneva A, Bussi Y, Lotan-Pompan M, Weinberger A, Shechter A, Chezar-Azerrad C, Arow Z, Hammer Y, Chechi K, Forslund SK, Fromentin S, Dumas ME, Ehrlich SD, Pedersen O, Kornowski R, Segal E:
Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease.
Nat Med. 2022 Feb;28(2):295-302. doi: 10.1038/s41591-022-01686-6. Epub 2022 Feb 17. PMID: 35177859

Coelho LP, Alves R, Del Río ÁR, Myers PN, Cantalapiedra CP, Giner-Lamia J, Schmidt TS, Mende DR, Orakov A, Letunic I, Hildebrand F, Van Rossum T, Forslund SK, Khedkar S, Maistrenko OM, Pan S, Jia L, Ferretti P, Sunagawa S, Zhao XM, Nielsen HB, Huerta-Cepas J, Bork P:
Towards the biogeography of prokaryotic genes.
Nature. 2022 Jan;601(7892):252-256. doi: 10.1038/s41586-021-04233-4. Epub 2021 Dec 15 PMID: 34912116

Haghikia A, Zimmermann F, Schumann P, Jasina A, Roessler J, Schmidt D, Heinze P, Kaisler J, Nageswaran V, Aigner A, Ceglarek U, Cineus R, Hegazy AN, van der Vorst EPC, Döring Y, Strauch CM, Nemet I, Tremaroli V, Dwibedi C, Kränkel N, Leistner DM, Heimesaat MM, Bereswill S, Rauch G, Seeland U, Soehnlein O, Müller DN, Gold R, Bäckhed F, Hazen SL, Haghikia A, Landmesser U:
Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism.
Eur Heart J. 2022 Feb 10;43(6):518-533. doi: 10.1093/eurheartj/ehab644. PMID: 34597388

Belda E, Voland L, Tremaroli V, Falony G, Adriouch S, Assmann KE, Prifti E, Aron-Wisnewsky J, Debédat J, Le Roy T, Nielsen T, Amouyal C, André S, Andreelli F, Blüher M, Chakaroun R, Chilloux J, Coelho LP, Dao MC, Das P, Fellahi S, Forslund S, Galleron N, Hansen TH, Holmes B, Ji B, Krogh Pedersen H, Le P, Le Chatelier E, Lewinter C, Mannerås-Holm L, Marquet F, Myridakis A, Pelloux V, Pons N, Quinquis B, Rouault C, Roume H, Salem JE, Sokolovska N, Søndertoft NB, Touch S, Vieira-Silva S; MetaCardis Consortium, Galan P, Holst J, Gøtze JP, Køber L, Vestergaard H, Hansen T, Hercberg S, Oppert JM, Nielsen J, Letunic I, Dumas ME, Stumvoll M, Pedersen OB, Bork P, Ehrlich SD, Zucker JD, Bäckhed F, Raes J, Clément K:
Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism.
Gut. 2022 Jan 11:gutjnl-2021-325753. doi: 10.1136/gutjnl-2021-325753. Online ahead of print. PMID: 35017197

Catar RA, Wischnewski O, Chen L, Heidecke H, Rutz C, Schülein R, Dragun D, Philippe A, Kusch A:
Non-HLA antibodies targeting angiotensin II Type 1 receptor and endothelin-1 Type A receptors induce endothelial injury via β2-arrestin link to mTOR pathway.
Kidney Int. 2022 Mar;101(3):498-509. doi: 10.1016/j.kint.2021.09.029. Epub 2021 Oct 29. PMID: 34757123

Mohammed M, Johnson DN, Wang LA, Harden SW, Sheng W, Spector EA, Elsaafien K, Bader M, Steckelings UM, Scott KA, Frazier CJ, Sumners C, Krause EG, de Kloet AD:
Targeting angiotensin type-2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice.
Cardiovasc Res. 2022 Feb 21;118(3):883-896. doi: 10.1093/cvr/cvab085. PMID: 33723600

Carlson CR, Aronsen JM, Bergan-Dahl A, Moutty MC, Lunde M, Lunde PK, Jarstadmarken H, Wanichawan P, Pereira L, Kolstad TRS, Dalhus B, Subramanian H, Hille S, Christensen G, Müller OJ, Nikolaev V, Bers DM, Sjaastad I, Shen X, Louch WE, Klussmann E, Sejersted OM:
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR.
Circ Res. 2022 Jan 7;130(1):27-44. doi: 10.1161/CIRCRESAHA.120.317976. Epub 2021 Nov 24. PMID: 34814703

Hahn T, Ernsting J, Winter NR, Holstein V, Leenings R, Beisemann M, Fisch L, Sarink K, Emden D, Opel N, Redlich R, Repple J, Grotegerd D, Meinert S, Hirsch JG, Niendorf T, Endemann B, Bamberg F, Kröncke T, Bülow R, Völzke H, von Stackelberg O, Sowade RF, Umutlu L, Schmidt B, Caspers S, Kugel H, Kircher T, Risse B, Gaser C, Cole JH, Dannlowski U, Berger K:
An uncertainty-aware, shareable, and transparent neural network architecture for brain-age modeling.
Sci Adv. 2022 Jan 7;8(1):eabg9471. doi: 10.1126/sciadv.abg9471. Epub 2022 Jan 5. PMID: 34985964

Braun T, Stachelscheid J, Bley N, Oberbeck S, Otte M, Müller TA, Wahnschaffe L, Glaß M, Ommer K, Franitza M, Gathof B, Altmüller J, Hallek M, Auguin D, Hüttelmaier S, Schrader A, Herling M:
Non-canonical function of AGO2 augments T-cell receptor signaling in T-cell prolymphocytic leukemia.
Cancer Res. 2022 Mar 8:canres.1908.2021. doi: 10.1158/0008-5472.CAN-21-1908. Online ahead of print. PMID: 35259248

Hilgers L, Roth O, Nolte AW, Schüller A, Spanke T, Flury JM, Utama IV, Altmüller J, Wowor D, Misof B, Herder F, Böhne A, Schwarzer J:
Inflammation and convergent placenta gene co-option contributed to a novel reproductive tissue.
Curr Biol. 2022 Feb 7;32(3):715-724.e4. doi: 10.1016/j.cub.2021.12.004. Epub 2021 Dec 20.PMID: 34932936

Kirschner KM, Foryst-Ludwig A, Gohlke S, Li C, Flores RE, Kintscher U, Schupp M, Schulz TJ, Scholz H:
Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet.
Diabetologia. 2022 Mar;65(3):528-540. doi: 10.1007/s00125-021-05621-1. Epub 2021 Nov 30. PMID: 34846543

Prinz C, Starke L, Millward JM, Fillmer A, Delgado PR, Waiczies H, Pohlmann A, Rothe M, Nazaré M, Paul F, Niendorf T, Waiczies S:
In vivo detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy.
Theranostics. 2021 Jan 1;11(6):2490-2504. doi: 10.7150/thno.47130. eCollection 2021. PMID: 33456555

Sciesielski LK, Felten M, Michalick L, Kirschner KM, Lattanzi G, Jacobi CLJ, Wallach T, Lang V, Landgraf D, Kramer A, Dame C:
The circadian clock regulates rhythmic erythropoietin expression in the murine kidney.
Kidney Int. 2021 Nov;100(5):1071-1080. doi: 10.1016/j.kint.2021.07.012. Epub 2021 Jul 30. PMID: 34332958

Rosswog C, Bartenhagen C, Welte A, Kahlert Y, Hemstedt N, Lorenz W, Cartolano M, Ackermann S, Perner S, Vogel W, Altmüller J, Nürnberg P, Hertwig F, Göhring G, Lilienweiss E, Stütz AM, Korbel JO, Thomas RK, Peifer M, Fischer M:
Chromothripsis followed by circular recombination drives oncogene amplification in human cancer.
Nat Genet. 2021 Dec;53(12):1673-1685. doi: 10.1038/s41588-021-00951-7. Epub 2021 Nov 15.PMID: 34782764

Chatzidoukaki O, Stratigi K, Goulielmaki E, Niotis G, Akalestou-Clocher A, Gkirtzimanaki K, Zafeiropoulos A, Altmüller J, Topalis P, Garinis GA:
R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage.
Sci Adv. 2021 Nov 19;7(47):eabj5769. doi: 10.1126/sciadv.abj5769. Epub 2021 Nov 19. PMID: 34797720

Boileau E, Altmüller J, Naarmann-de Vries IS, Dieterich C:
A comparison of metabolic labeling and statistical methods to infer genome-wide dynamics of RNA turnover.
Brief Bioinform. 2021 Nov 5;22(6):bbab219. doi: 10.1093/bib/bbab219. PMID: 34228787

Zhang S, Übelmesser N, Josipovic N, Forte G, Slotman JA, Chiang M, Gothe HJ, Gusmao EG, Becker C, Altmüller J, Houtsmuller AB, Roukos V, Wendt KS, Marenduzzo D, Papantonis A:
RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis.
Sci Adv. 2021 Oct 22;7(43):eabg8205. doi: 10.1126/sciadv.abg8205. Epub 2021 Oct 22. PMID: 34678064

Gabriel E, Albanna W, Pasquini G, Ramani A, Josipovic N, Mariappan A, Schinzel F, Karch CM, Bao G, Gottardo M, Suren AA, Hescheler J, Nagel-Wolfrum K, Persico V, Rizzoli SO, Altmüller J, Riparbelli MG, Callaini G, Goureau O, Papantonis A, Busskamp V, Schneider T, Gopalakrishnan J:
Human brain organoids assemble functionally integrated bilateral optic vesicles.
Cell Stem Cell. 2021 Oct 7;28(10):1740-1757.e8. doi: 10.1016/j.stem.2021.07.010. Epub 2021 Aug 17. PMID: 34407456

Kirschner GK, Rosignoli S, Guo L, Vardanega I, Imani J, Altmüller J, Milner SG, Balzano R, Nagel KA, Pflugfelder D, Forestan C, Bovina R, Koller R, Stöcker TG, Mascher M, Simmonds J, Uauy C, Schoof H, Tuberosa R, Salvi S, Hochholdinger F:
ENHANCED GRAVITROPISM 2 encodes a STERILE ALPHA MOTIF-containing protein that controls root growth angle in barley and wheat.
Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2101526118. doi: 10.1073/pnas.2101526118.PMID: 34446550

Koester J, Miroshnikova YA, Ghatak S, Chacón-Martínez CA, Morgner J, Li X, Atanassov I, Altmüller J, Birk DE, Koch M, Bloch W, Bartusel M, Niessen CM, Rada-Iglesias A, Wickström SA:
Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility.
Nat Cell Biol. 2021 Jul;23(7):771-781. doi: 10.1038/s41556-021-00705-x. Epub 2021 Jul 8.PMID: 34239060

Boehm V, Kueckelmann S, Gerbracht JV, Kallabis S, Britto-Borges T, Altmüller J, Krüger M, Dieterich C, Gehring NH:
SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity.
Nat Commun. 2021 Jun 25;12(1):3965. doi: 10.1038/s41467-021-24046-3. PMID: 34172724

Warnat-Herresthal S, Schultze H, Shastry KL, Manamohan S, Mukherjee S, Garg V, Sarveswara R, Händler K, Pickkers P, Aziz NA, Ktena S, Tran F, Bitzer M, Ossowski S, Casadei N, Herr C, Petersheim D, Behrends U, Kern F, Fehlmann T, Schommers P, Lehmann C, Augustin M, Rybniker J, Altmüller J, Mishra N, Bernardes JP, Krämer B, Bonaguro L, Schulte-Schrepping J, De Domenico E, Siever C, Kraut M, Desai M, Monnet B, Saridaki M, Siegel CM, Drews A, Nuesch-Germano M, Theis H, Heyckendorf J, Schreiber S, Kim-Hellmuth S; COVID-19 Aachen Study (COVAS), Nattermann J, Skowasch D, Kurth I, Keller A, Bals R, Nürnberg P, Rieß O, Rosenstiel P, Netea MG, Theis F, Mukherjee S, Backes M, Aschenbrenner AC, Ulas T; Deutsche COVID-19 Omics Initiative (DeCOI), Breteler MMB, Giamarellos-Bourboulis EJ, Kox M, Becker M, Cheran S, Woodacre MS, Goh EL, Schultze JL:
Swarm Learning for decentralized and confidential clinical machine learning.
Nature. 2021 Jun;594(7862):265-270. doi: 10.1038/s41586-021-03583-3. Epub 2021 May 26.PMID: 34040261

Sofiadis K, Josipovic N, Nikolic M, Kargapolova Y, Übelmesser N, Varamogianni-Mamatsi V, Zirkel A, Papadionysiou I, Loughran G, Keane J, Michel A, Gusmao EG, Becker C, Altmüller J, Georgomanolis T, Mizi A, Papantonis A:
HMGB1 coordinates SASP-related chromatin folding and RNA homeostasis on the path to senescence.
Mol Syst Biol. 2021 Jun;17(6):e9760. doi: 10.15252/msb.20209760. PMID: 34166567

Goulielmaki E, Tsekrekou M, Batsiotos N, Ascensão-Ferreira M, Ledaki E, Stratigi K, Chatzinikolaou G, Topalis P, Kosteas T, Altmüller J, Demmers JA, Barbosa-Morais NL, Garinis GA:
The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing.
Nat Commun. 2021 May 26;12(1):3153. doi: 10.1038/s41467-021-23505-1. PMID: 34039990

Kargapolova Y, Rehimi R, Kayserili H, Brühl J, Sofiadis K, Zirkel A, Palikyras S, Mizi A, Li Y, Yigit G, Hoischen A, Frank S, Russ N, Trautwein J, van Bon B, Gilissen C, Laugsch M, Gusmao EG, Josipovic N, Altmüller J, Nürnberg P, Längst G, Kaiser FJ, Watrin E, Brunner H, Rada-Iglesias A, Kurian L, Wollnik B, Bouazoune K, Papantonis A:
Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology.
Nat Commun. 2021 May 21;12(1):3014. doi: 10.1038/s41467-021-23327-1. PMID: 34021162

Homberg JR, Adan RAH, Alenina N, Asiminas A, Bader M, Beckers T, Begg DP, Blokland A, Burger ME, van Dijk G, Eisel ULM, Elgersma Y, Englitz B, Fernandez-Ruiz A, Fitzsimons CP, van Dam AM, Gass P, Grandjean J, Havekes R, Henckens MJAG, Herden C, Hut RA, Jarrett W, Jeffrey K, Jezova D, Kalsbeek A, Kamermans M, Kas MJ, Kasri NN, Kiliaan AJ, Kolk SM, Korosi A, Korte SM, Kozicz T, Kushner SA, Leech K, Lesch KP, Lesscher H, Lucassen PJ, Luthi A, Ma L, Mallien AS, Meerlo P, Mejias JF, Meye FJ, Mitchell AS, Mul JD, Olcese U, González AO, Olivier JDA, Pasqualetti M, Pennartz CMA, Popik P, Prickaerts J, de la Prida LM, Ribeiro S, Roozendaal B, Rossato JI, Salari AA, Schoemaker RG, Smit AB, Vanderschuren LJMJ, Takeuchi T, van der Veen R, Smidt MP, Vyazovskiy VV, Wiesmann M, Wierenga CJ, Williams B, Willuhn I, Wöhr M, Wolvekamp M, van der Zee EA, Genzel L:
The continued need for animals to advance brain research.
Neuron. 2021 Aug 4;109(15):2374-2379. doi: 10.1016/j.neuron.2021.07.015. PMID: 34352213

Katz M, Subramaniam S, Chomsky-Hecht O, Tsemakhovich V, Flockerzi V, Klussmann E, Hirsch JA, Weiss S, Dascal N:
Reconstitution of β-adrenergic regulation of CaV1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2100021118. doi: 10.1073/pnas.2100021118. PMID: 34001616

Hu W, Jiang S, Liao Y, Li J, Dong F, Guo J, Wang X, Fei L, Cui Y, Ren X, Xu N, Zhao L, Chen L, Zheng Y, Li L, Patzak A, Persson PB, Zheng Z, Lai EY:
High phosphate impairs arterial endothelial function through AMPK-related pathways in mouse resistance arteries.
Acta Physiol 2021 Apr 231 (4):e13595. Doi: 10.1111/apha.13595. PMID: 33835704

Forslund SK, Chakaroun R, Zimmermann-Kogadeeva M, Markó L, Aron-Wisnewsky J, Nielsen T, Moitinho-Silva L, Schmidt TSB, Falony G, Vieira-Silva S, Adriouch S, Alves RJ, Assmann K, Bastard JP, Birkner T, Caesar R, Chilloux J, Coelho LP, Fezeu L, Galleron N, Helft G, Isnard R, Ji B, Kuhn M, Le Chatelier E, Myridakis A, Olsson L, Pons N, Prifti E, Quinquis B, Roume H, Salem JE, Sokolovska N, Tremaroli V, Valles-Colomer M, Lewinter C, Søndertoft NB, Pedersen HK, Hansen TH; MetaCardis Consortium*, Gøtze JP, Køber L, Vestergaard H, Hansen T, Zucker JD, Hercberg S, Oppert JM, Letunic I, Nielsen J, Bäckhed F, Ehrlich SD, Dumas ME, Raes J, Pedersen O, Clément K, Stumvoll M, Bork P:
Combinatorial, additive and dose-dependent drug-microbiome associations.
Nature. 2021 Dec;600(7889):500-505. doi: 10.1038/s41586-021-04177-9. Epub 2021 Dec 8. PMID: 34880489

Schütte T, Kedziora SM, Haase N, Herse F, Alenina N, Müller DN, Bader M, Schupp M, Dechend R, Golic M, Kräker K:
Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring-the heart as a target for fetal programming in rats.
Diabetologia. 2021 Dec;64(12):2829-2842. doi: 10.1007/s00125-021-05566-5. Epub 2021 Sep 18. PMID: 34537857

Mirzayi C, Renson A; Genomic Standards Consortium; Massive Analysis and Quality Control Society, Zohra F, Elsafoury S, Geistlinger L, Kasselman LJ, Eckenrode K, van de Wijgert J, Loughman A, Marques FZ, MacIntyre DA, Arumugam M, Azhar R, Beghini F, Bergstrom K, Bhatt A, Bisanz JE, Braun J, Bravo HC, Buck GA, Bushman F, Casero D, Clarke G, Collado MC, Cotter PD, Cryan JF, Demmer RT, Devkota S, Elinav E, Escobar JS, Fettweis J, Finn RD, Fodor AA, Forslund S, Franke A, Furlanello C, Gilbert J, Grice E, Haibe-Kains B, Handley S, Herd P, Holmes S, Jacobs JP, Karstens L, Knight R, Knights D, Koren O, Kwon DS, Langille M, Lindsay B, McGovern D, McHardy AC, McWeeney S, Mueller NT, Nezi L, Olm M, Palm N, Pasolli E, Raes J, Redinbo MR, Rühlemann M, Balfour Sartor R, Schloss PD, Schriml L, Segal E, Shardell M, Sharpton T, Smirnova E, Sokol H, Sonnenburg JL, Srinivasan S, Thingholm LB, Turnbaugh PJ, Upadhyay V, Walls RL, Wilmes P, Yamada T, Zeller G, Zhang M, Zhao N, Zhao L, Bao W, Culhane A, Devanarayan V, Dopazo J, Fan X, Fischer M, Jones W, Kusko R, Mason CE, Mercer TR, Sansone SA, Scherer A, Shi L, Thakkar S, Tong W, Wolfinger R, Hunter C, Segata N, Huttenhower C, Dowd JB, Jones HE, Waldron L:
Reporting guidelines for human microbiome research: the STORMS checklist.
Nat Med. 2021 Nov;27(11):1885-1892. doi: 10.1038/s41591-021-01552-x. Epub 2021 Nov 17. PMID: 34789871

Maier L, Goemans CV, Wirbel J, Kuhn M, Eberl C, Pruteanu M, Müller P, Garcia-Santamarina S, Cacace E, Zhang B, Gekeler C, Banerjee T, Anderson EE, Milanese A, Löber U, Forslund SK, Patil KR, Zimmermann M, Stecher B, Zeller G, Bork P, Typas A:
Unravelling the collateral damage of antibiotics on gut bacteria.
Nature. 2021 Nov;599(7883):120-124. doi: 10.1038/s41586-021-03986-2. Epub 2021 Oct 13. PMID: 34646011

Brial F, Chilloux J, Nielsen T, Vieira-Silva S, Falony G, Andrikopoulos P, Olanipekun M, Hoyles L, Djouadi F, Neves AL, Rodriguez-Martinez A, Mouawad GI, Pons N, Forslund S, Le-Chatelier E, Le Lay A, Nicholson J, Hansen T, Hyötyläinen T, Clément K, Oresic M, Bork P, Ehrlich SD, Raes J, Pedersen OB, Gauguier D, Dumas ME:
Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health.
Gut. 2021 Nov;70(11):2105-2114. doi: 10.1136/gutjnl-2020-323314. Epub 2021 May 11. PMID: 33975870

Chiva-Blanch G, Müller DN:
Targeted diets for the gut microbiota and the potential cardiovascular effects.
Cardiovasc Res. 2021 Sep 28;117(11):e135-e137. doi: 10.1093/cvr/cvab276. PMID: 34477831

Gawałko M, Agbaedeng TA, Saljic A, Müller DN, Wilck N, Schnabel R, Penders J, Rienstra M, van Gelder I, Jespersen T, Schotten U, Crijns HJGM, Kalman JM, Sanders P, Nattel S, Dobrev D, Linz D:
Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications.
Cardiovasc Res. 2021 Sep 22:cvab292. doi: 10.1093/cvr/cvab292. Online ahead of print. PMID: 34550344

Huhn K, Linz P, Pemsel F, Michalke B, Seyferth S, Kopp C, Chaudri MA, Rothhammer V, Dörfler A, Uder M, Nagel AM, Müller DN, Waschbisch A, Lee DH, Bäuerle T, Linker RA, Haase S:
Skin sodium is increased in male patients with multiple sclerosis and related animal models.
Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):e2102549118. doi: 10.1073/pnas.2102549118. PMID: 34260395

Geisberger S, Bartolomaeus H, Neubert P, Willebrand R, Zasada C, Bartolomaeus T, McParland V, Swinnen D, Geuzens A, Maifeld A, Krampert L, Vogl M, Mähler A, Wilck N, Markó L, Tilic E, Forslund SK, Binger KJ, Stegbauer J, Dechend R, Kleinewietfeld M, Jantsch J, Kempa S, Müller DN:
Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes.
Circulation. 2021 Jul 13;144(2):144-158. doi: 10.1161/CIRCULATIONAHA.120.052788. Epub 2021 Apr 28. PMID: 33906377

Armada-Moreira A, Cizauskas C, Fleury G, Forslund SK, Guthman EM, Hanafiah A, Hope JM, Jayasinghe I, McSweeney D, Young ID:
STEM Pride: Perspectives from transgender, nonbinary, and genderqueer scientists.
Cell. 2021 Jun 24;184(13):3352-3355. doi: 10.1016/j.cell.2021.05.043. PMID: 34171316

Thiele A, Luettges K, Ritter D, Beyhoff N, Smeir E, Grune J, Steinhoff JS, Schupp M, Klopfleisch R, Rothe M, Wilck N, Bartolomaeus H, Migglautsch AK, Breinbauer R, Kershaw EE, Grabner GF, Zechner R, Kintscher U, Foryst-Ludwig A:
Pharmacological inhibition of adipose tissue Adipose Triglyceride Lipase (ATGL) by Atglistatin prevents catecholamine-induced myocardial damage.
Cardiovasc Res. 2021 Jun 1:cvab182. doi: 10.1093/cvr/cvab182. Online ahead of print. PMID: 34061169

Jobin K, Müller DN, Jantsch J, Kurts C:
Sodium and its manifold impact on our immune system.
Trends Immunol. 2021 Jun;42(6):469-479. doi: 10.1016/j.it.2021.04.002. Epub 2021 May 4. PMID: 33962888 Review

Avery EG, Bartolomaeus H, Maifeld A, Marko L, Wiig H, Wilck N, Rosshart SP, Forslund SK, Müller DN:
The Gut Microbiome in Hypertension: Recent Advances and Future Perspectives.
Circ Res. 2021 Apr 2;128(7):934-950. doi: 10.1161/CIRCRESAHA.121.318065. Epub 2021 Apr 1. PMID: 33793332

Maifeld A, Bartolomaeus H, Löber U, Avery EG, Steckhan N, Markó L, Wilck N, Hamad I, Šušnjar U, Mähler A, Hohmann C, Chen CY, Cramer H, Dobos G, Lesker TR, Strowig T, Dechend R, Bzdok D, Kleinewietfeld M, Michalsen A, Müller DN, Forslund SK:
Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.
Nat Commun. 2021 Mar 30;12(1):1970. doi: 10.1038/s41467-021-22097-0. PMID: 33785752

Bartolomaeus TUP, Birkner T, Bartolomaeus H, Löber U, Avery EG, Mähler A, Weber D, Kochlik B, Balogh A, Wilck N, Boschmann M, Müller DN, Markó L, Forslund SK:
Quantifying technical confounders in microbiome studies.
Cardiovasc Res. 2021 Feb 22;117(3):863-875. doi: 10.1093/cvr/cvaa128. PMID: 32374853

Gotti GC, Kikhia M, Wuntke V, Hasam-Henderson LA, Wu B, Geiger JRP, Kovacs R:
In situ labeling of non-accommodating interneurons based on metabolic rates.
Redox Biol. 2021 Jan;38:101798. doi: 10.1016/j.redox.2020.101798. Epub 2020 Nov 28. PMID: 33285412

Wallach T, Mossmann ZJ, Szczepek M, Wetzel M, Machado R, Raden M, Miladi M, Kleinau G, Krüger C, Dembny P, Adler D, Zhai Y, Kumbol V, Dzaye O, Schüler J, Futschik M, Backofen R, Scheerer P, Lehnardt S:
MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration.
Mol Neurodegener. 2021 Nov 27;16(1):80. doi: 10.1186/s13024-021-00498-5. PMID: 34838071

Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Bürger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Kühnen P, Kobilka BK, Scheerer P:
Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide.
Cell Res. 2021 Nov;31(11):1176-1189. doi: 10.1038/s41422-021-00569-8. Epub 2021 Sep 24. PMID: 34561620

Schütte T, Kedziora SM, Haase N, Herse F, Busjahn A, Birukov A, Alenina N, Müller DN, Bader M, Schupp M, Dechend R, Kräker K, Golic M:
Intrauterine Exposure to Diabetic Milieu Does Not Induce Diabetes and Obesity in Male Adulthood in a Novel Rat Mode.
Hypertension. 2021 Jan;77(1):202-215. doi: 10.1161/HYPERTENSIONAHA.120.16360. Epub 2020 Nov 30. PMID: 33249866

Mannweiler R, Bergmann S, Vidal-Y-Sy S, Brandner JM, Günzel D:
Direct assessment of individual skin barrier components by electrical impedance spectroscopy.
Allergy. 2021 Oct;76(10):3094-3106. doi: 10.1111/all.14851. Epub 2021 May 5. PMID: 33844311

Gao X, Bender F, Soh H, Chen C, Altafi M, Schütze S, Heidenreich M, Gorbati M, Corbu MA, Carus-Cadavieco M, Korotkova T, Tzingounis AV, Jentsch TJ, Ponomarenko A:
Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.
Nat Commun. 2021 Aug 10;12(1):4801. doi: 10.1038/s41467-021-24805-2. PMID: 34376649

Kaminski MM, Abudayyeh OO, Gootenberg JS, Zhang F, Collins JJ:
CRISPR-based diagnostics.
Nat Biomed Eng. 2021 Jul;5(7):643-656. doi: 10.1038/s41551-021-00760-7. Epub 2021 Jul 16. PMID: 34272525

Vavassori S, Chou J, Faletti LE, Haunerdinger V, Opitz L, Joset P, Fraser CJ, Prader S, Gao X, Schuch LA, Wagner M, Hoefele J, Maccari ME, Zhu Y, Elakis G, Gabbett MT, Forstner M, Omran H, Kaiser T, Kessler C, Olbrich H, Frosk P, Almutairi A, Platt CD, Elkins M, Weeks S, Rubin T, Planas R, Marchetti T, Koovely D, Klämbt V, Soliman NA, von Hardenberg S, Klemann C, Baumann U, Lenz D, Klein-Franke A, Schwemmle M, Huber M, Sturm E, Hartleif S, Häffner K, Gimpel C, Brotschi B, Laube G, Güngör T, Buckley MF, Kottke R, Staufner C, Hildebrandt F, Reu-Hofer S, Moll S, Weber A, Kaur H, Ehl S, Hiller S, Geha R, Roscioli T, Griese M, Pachlopnik Schmid J:
Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency.
J Allergy Clin Immunol. 2021 Aug;148(2):381-393. doi: 10.1016/j.jaci.2021.03.045. Epub 2021 Apr 17. PMID: 33872655

Mann N, Mzoughi S, Schneider R, Kühl SJ, Schanze D, Klämbt V, Lovric S, Mao Y, Shi S, Tan W, Kühl M, Onuchic-Whitford AC, Treimer E, Kitzler TM, Kause F, Schumann S, Nakayama M, Buerger F, Shril S, van der Ven AT, Majmundar AJ, Holton KM, Kolb A, Braun DA, Rao J, Jobst-Schwan T, Mildenberger E, Lennert T, Kuechler A, Wieczorek D, Gross O, Ermisch-Omran B, Werberger A, Skalej M, Janecke AR, Soliman NA, Mane SM, Lifton RP, Kadlec J, Guccione E, Schmeisser MJ, Zenker M, Hildebrandt F:
Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome.
J Am Soc Nephrol. 2021 Mar;32(3):580-596. doi: 10.1681/ASN.2020040490. Epub 2021 Feb 16. PMID: 33593823

Weng PL, Majmundar AJ, Khan K, Lim TY, Shril S, Jin G, Musgrove J, Wang M, Ahram DF, Aggarwal VS, Bier LE, Heinzen EL, Onuchic-Whitford AC, Mann N, Buerger F, Schneider R, Deutsch K, Kitzler TM, Klämbt V, Kolb A, Mao Y, Moufawad El Achkar C, Mitrotti A, Martino J, Beck BB, Altmüller J, Benz MR, Yano S, Mikati MA, Gunduz T, Cope H, Shashi V; Undiagnosed Diseases Network, Trachtman H, Bodria M, Caridi G, Pisani I, Fiaccadori E, AbuMaziad AS, Martinez-Agosto JA, Yadin O, Zuckerman J, Kim A; UCLA Clinical Genomics Center, John-Kroegel U, Tyndall AV, Parboosingh JS, Innes AM, Bierzynska A, Koziell AB, Muorah M, Saleem MA, Hoefele J, Riedhammer KM, Gharavi AG, Jobanputra V, Pierce-Hoffman E, Seaby EG, O'Donnell-Luria A, Rehm HL, Mane S, D'Agati VD, Pollak MR, Ghiggeri GM, Lifton RP, Goldstein DB, Davis EE, Hildebrandt F, Sanna-Cherchi S:
De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis.
Am J Hum Genet. 2021 Feb 4;108(2):357-367. doi: 10.1016/j.ajhg.2021.01.008. Epub 2021 Jan 27. PMID: 33508234

Duncan AR, Polovitskaya MM, Gaitán-Peñas H, Bertelli S, VanNoy GE, Grant PE, O'Donnell-Luria A, Valivullah Z, Lovgren AK, England EM, Agolini E, Madden JA, Schmitz-Abe K, Kritzer A, Hawley P, Novelli A, Alfieri P, Colafati GS, Wieczorek D, Platzer K, Luppe J, Koch-Hogrebe M, Abou Jamra R, Neira-Fresneda J, Lehman A, Boerkoel CF, Seath K, Clarke L; CAUSES Study, van Ierland Y, Argilli E, Sherr EH, Maiorana A, Diel T, Hempel M, Bierhals T, Estévez R, Jentsch TJ, Pusch M, Agrawal PB:
Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders.
Am J Hum Genet. 2021 Aug 5;108(8):1450-1465. doi: 10.1016/j.ajhg.2021.06.003. Epub 2021 Jun 28.PMID: 34186028

Drescher D, Büchner T, Schrade P, Traub H, Werner S, Guttmann P, Bachmann S, Kneipp J:
Influence of Nuclear Localization Sequences on the Intracellular Fate of Gold Nanoparticles.
ACS Nano. 2021 Sep 28;15(9):14838-14849. doi: 10.1021/acsnano.1c04925. Epub 2021 Aug 30. PMID: 34460234

Steindl D, Boehmerle W, Körner R, Praeger D, Haug M, Nee J, Schreiber A, Scheibe F, Demin K, Jacoby P, Tauber R, Hartwig S, Endres M, Eckardt KU:
Novichok nerve agent poisoning.
Lancet. 2021 Jan 16;397(10270):249-252. doi: 10.1016/S0140-6736(20)32644-1. Epub 2020 Dec 23. PMID: 33357496

Xu K, Yin N, Peng M, Stamatiades EG, Chhangawala S, Shyu A, Li P, Zhang X, Do MH, Capistrano KJ, Chou C, Leslie CS, Li MO:
Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses.
Immunity. 2021 May 11;54(5):976-987.e7. doi: 10.1016/j.immuni.2021.04.008. PMID: 33979589

Pascual-Reguant A, Köhler R, Mothes R, Bauherr S, Hernández DC, Uecker R, Holzwarth K, Kotsch K, Seidl M, Philipsen L, Müller W, Romagnani C, Niesner R, Hauser AE:
Multiplexed histology analyses for the phenotypic and spatial characterization of human innate lymphoid cells.
Nat Commun. 2021 Mar 19;12(1):1737. doi: 10.1038/s41467-021-21994-8. PMID: 33741932

Xu K, Yin N, Peng M, Stamatiades EG, Shyu A, Li P, Zhang X, Do MH, Wang Z, Capistrano KJ, Chou C, Levine AG, Rudensky AY, Li MO:
Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity.
Science. 2021 Jan 22;371(6527):405-410. doi: 10.1126/science.abb2683. PMID: 33479154

Lamarthée B, Marchal A, Charbonnier S, Blein T, Leon J, Martin E, Rabaux L, Vogt K, Titeux M, Delville M, Vinçon H, Six E, Pallet N, Michonneau D, Anglicheau D, Legendre C, Taupin JL, Nemazanyy I, Sawitzki B, Latour S, Cavazzana M, André I, Zuber J:
Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction.
Nat Commun. 2021 Nov 8;12(1):6446. doi: 10.1038/s41467-021-26844-1. PMID: 34750385

Uhlitz F, Bischoff P, Peidli S, Sieber A, Trinks A, Lüthen M, Obermayer B, Blanc E, Ruchiy Y, Sell T, Mamlouk S, Arsie R, Wei TT, Klotz-Noack K, Schwarz RF, Sawitzki B, Kamphues C, Beule D, Landthaler M, Sers C, Horst D, Blüthgen N, Morkel M:
Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.
EMBO Mol Med. 2021 Oct 7;13(10):e14123. doi: 10.15252/emmm.202114123. Epub 2021 Aug 19. PMID: 34409732

Tin A, Schlosser P, Matias-Garcia PR, Thio CHL, Joehanes R, Liu H, Yu Z, Weihs A, Hoppmann A, Grundner-Culemann F, Min JL, Kuhns VLH, Adeyemo AA, Agyemang C, Ärnlöv J, Aziz NA, Baccarelli A, Bochud M, Brenner H, Bressler J, Breteler MMB, Carmeli C, Chaker L, Coresh J, Corre T, Correa A, Cox SR, Delgado GE, Eckardt KU, Ekici AB, Endlich K, Floyd JS, Fraszczyk E, Gao X, Gào X, Gelber AC, Ghanbari M, Ghasemi S, Gieger C, Greenland P, Grove ML, Harris SE, Hemani G, Henneman P, Herder C, Horvath S, Hou L, Hurme MA, Hwang SJ, Kardia SLR, Kasela S, Kleber ME, Koenig W, Kooner JS, Kronenberg F, Kühnel B, Ladd-Acosta C, Lehtimäki T, Lind L, Liu D, Lloyd-Jones DM, Lorkowski S, Lu AT, Marioni RE, März W, McCartney DL, Meeks KAC, Milani L, Mishra PP, Nauck M, Nowak C, Peters A, Prokisch H, Psaty BM, Raitakari OT, Ratliff SM, Reiner AP, Schöttker B, Schwartz J, Sedaghat S, Smith JA, Sotoodehnia N, Stocker HR, Stringhini S, Sundström J, Swenson BR, van Meurs JBJ, van Vliet-Ostaptchouk JV, Venema A, Völker U, Winkelmann J, Wolffenbuttel BHR, Zhao W, Zheng Y; Estonian Biobank Research Team; Genetics of DNA Methylation Consortium, Loh M, Snieder H, Waldenberger M, Levy D, Akilesh S, Woodward OM, Susztak K, Teumer A, Köttgen A:
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.
Nat Commun. 2021 Dec 9;12(1):7173. doi: 10.1038/s41467-021-27198-4. PMID: 34887389

Schachtl-Riess JF, Kheirkhah A, Grüneis R, Di Maio S, Schoenherr S, Streiter G, Losso JL, Paulweber B, Eckardt KU, Köttgen A, Lamina C, Kronenberg F, Coassin S; GCKD Investigators:
Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease.
J Am Coll Cardiol. 2021 Aug 3;78(5):437-449. doi: 10.1016/j.jacc.2021.05.037. PMID: 34325833

Alesutan I, Luong TTD, Schelski N, Masyout J, Hille S, Schneider MP, Graham D, Zickler D, Verheyen N, Estepa M, Pasch A, Maerz W, Tomaschitz A, Pilz S, Frey N, Lang F, Delles C, Müller OJ, Pieske B, Eckardt KU, Scherberich J, Voelkl J:
Circulating uromodulin inhibits vascular calcification by interfering with pro-inflammatory cytokine signalling.
Cardiovasc Res. 2021 Feb 22;117(3):930-941. doi: 10.1093/cvr/cvaa081. PMID: 32243494

Mylonas E, Yoshida K, Frick M, Hoyer K, Christen F, Kaeda J, Obenaus M, Noerenberg D, Hennch C, Chan W, Ochi Y, Shiraishi Y, Shiozawa Y, Zenz T, Oakes CC, Sawitzki B, Schwarz M, Bullinger L, le Coutre P, Rose-Zerilli MJJ, Ogawa S, Damm F:
Single-cell analysis based dissection of clonality in myelofibrosis.
Nat Commun. 2020 Jan 7;11(1):73. doi: 10.1038/s41467-019-13892-x. PMID: 31911629

Willers M, Ulas T, Völlger L, Vogl T, Heinemann AS, Pirr S, Pagel J, Fehlhaber B, Halle O, Schöning J, Schreek S, Löber U, Essex M, Hombach P, Graspeuntner S, Basic M, Bleich A, Cloppenborg-Schmidt K, Künzel S, Jonigk D, Rupp J, Hansen G, Förster R, Baines JF, Härtel C, Schultze JL, Forslund SK, Roth J, Viemann D:
S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants.
Gastroenterology. 2020 Dec;159(6):2130-2145.e5. doi: 10.1053/j.gastro.2020.08.019. Epub 2020 Aug 15. PMID: 32805279

Molinaro A, Bel Lassen P, Henricsson M, Wu H, Adriouch S, Belda E, Chakaroun R, Nielsen T, Bergh PO, Rouault C, André S, Marquet F, Andreelli F, Salem JE, Assmann K, Bastard JP, Forslund S, Le Chatelier E, Falony G, Pons N, Prifti E, Quinquis B, Roume H, Vieira-Silva S, Hansen TH, Pedersen HK, Lewinter C, Sønderskov NB; MetaCardis Consortium, Køber L, Vestergaard H, Hansen T, Zucker JD, Galan P, Dumas ME, Raes J, Oppert JM, Letunic I, Nielsen J, Bork P, Ehrlich SD, Stumvoll M, Pedersen O, Aron-Wisnewsky J, Clément K, Bäckhed F:
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology.
Nat Commun. 2020 Nov 18;11(1):5881. doi: 10.1038/s41467-020-19589-w.PMID: 33208748

Birukov A, Herse F, Nielsen JH, Kyhl HB, Golic M, Kräker K, Haase N, Busjahn A, Bruun S, Jensen BL, Müller DN, Jensen TK, Christesen HT, Andersen MS, Jørgensen JS, Dechend R, Andersen LB:
Blood Pressure and Angiogenic Markers in Pregnancy: Contributors to Pregnancy-Induced Hypertension and Offspring Cardiovascular Risk.  
Hypertension. 2020 Sep;76(3):901-909. doi: 10.1161/HYPERTENSIONAHA.119.13966. Epub 2020 Jun 8. PMID: 32507044

Haase N, Foster DJ, Cunningham MW, Bercher J, Nguyen T, Shulga-Morskaya S, Milstein S, Shaikh S, Rollins J, Golic M, Herse F, Kräker K, Bendix I, Serdar M, Napieczynska H, Heuser A, Gellhaus A, Thiele K, Wallukat G, Müller DN, LaMarca B, Dechend R:
RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.
J Clin Invest. 2020 Jun 1;130(6):2928-2942. doi: 10.1172/JCI99417. PMID: 32338644

Bartolomaeus H, Avery EG, Bartolomaeus TUP, Kozhakhmetov S, Zhumadilov Z, Müller DN, Wilck N, Kushugulova A, Forslund SK:
Blood pressure changes correlate with short-chain fatty acid production potential shifts under a synbiotic intervention.
Cardiovasc Res. 2020 Jun 1;116(7):1252-1253. doi: 10.1093/cvr/cvaa083. PMID: 32232443

Vieira-Silva S, Falony G, Belda E, Nielsen T, Aron-Wisnewsky J, Chakaroun R, Forslund SK, Assmann K, Valles-Colomer M, Nguyen TTD, Proost S, Prifti E, Tremaroli V, Pons N, Le Chatelier E, Andreelli F, Bastard JP, Coelho LP, Galleron N, Hansen TH, Hulot JS, Lewinter C, Pedersen HK, Quinquis B, Rouault C, Roume H, Salem JE, Søndertoft NB, Touch S; MetaCardis Consortium, Dumas ME, Ehrlich SD, Galan P, Gøtze JP, Hansen T, Holst JJ, Køber L, Letunic I, Nielsen J, Oppert JM, Stumvoll M, Vestergaard H, Zucker JD, Bork P, Pedersen O, Bäckhed F, Clément K, Raes J:
Statin therapy is associated with lower prevalence of gut microbiota dysbiosis.
Nature. 2020 May;581(7808):310-315. doi: 10.1038/s41586-020-2269-x. Epub 2020 May 6. PMID: 32433607

Birukov A, Wiesemann S, Golic M, Balogh A, Marko L, Rakova N, Wilck N, Blaszczyk E, Lim C, Weiss S, Kräker K, Haase N, Frolova A, Jørgensen JS, Daub S, Müller DN, Herse F, Schulz-Menger J, Dechend R:
Myocardial Evaluation of Post-Preeclamptic Women by CMR: Is Early Risk Stratification Possible?
JACC Cardiovasc Imaging. 2020 May;13(5):1291-1293. doi: 10.1016/j.jcmg.2020.01.005. Epub 2020 Feb 12. PMID: 32061559

Matthaeus C, Lahmann I, Kunz S, Jonas W, Melo AA, Lehmann M, Larsson E, Lundmark R, Kern M, Blüher M, Olschowski H, Kompa J, Brügger B, Müller DN, Haucke V, Schürmann A, Birchmeier C, Daumke O:
EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.
Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7471-7481. doi: 10.1073/pnas.1918415117. Epub 2020 Mar 13. PMID: 32170013

Duscha A, Gisevius B, Hirschberg S, Yissachar N, Stangl GI, Eilers E, Bader V, Haase S, Kaisler J, David C, Schneider R, Troisi R, Zent D, Hegelmaier T, Dokalis N, Gerstein S, Del Mare-Roumani S, Amidror S, Staszewski O, Poschmann G, Stühler K, Hirche F, Balogh A, Kempa S, Träger P, Zaiss MM, Holm JB, Massa MG, Nielsen HB, Faissner A, Lukas C, Gatermann SG, Scholz M, Przuntek H, Prinz M, Forslund SK, Winklhofer KF, Müller DN, Linker RA, Gold R, Haghikia A:
Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism.
Cell. 2020 Mar 19;180(6):1067-1080.e16. doi: 10.1016/j.cell.2020.02.035. Epub 2020 Mar 10 .PMID: 32160527

Schimmel K, Jung M, Foinquinos A, José GS, Beaumont J, Bock K, Grote-Levi L, Xiao K, Bär C, Pfanne A, Just A, Zimmer K, Ngoy S, López B, Ravassa S, Samolovac S, Janssen-Peters H, Remke J, Scherf K, Dangwal S, Piccoli MT, Kleemiss F, Kreutzer FP, Kenneweg F, Leonardy J, Hobuß L, Santer L, Do QT, Geffers R, Braesen JH, Schmitz J, Brandenberger C, Müller DN, Wilck N, Kaever V, Bähre H, Batkai S, Fiedler J, Alexander KM, Wertheim BM, Fisch S, Liao R, Diez J, González A, Thum T:
Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction.
Circulation. 2020 Mar 3;141(9):751-767. doi: 10.1161/CIRCULATIONAHA.119.042559. Epub 2020 Jan 17. PMID: 31948273

Bartolomaeus TUP, Forslund SK:
Hitchhiker's guide to microbiome studies.
Cardiovasc Res. 2020 Mar 1;116(3):e44-e47. doi: 10.1093/cvr/cvz316. PMID: 31876912

Mende DR, Letunic I, Maistrenko OM, Schmidt TSB, Milanese A, Paoli L, Hernández-Plaza A, Orakov AN, Forslund SK, Sunagawa S, Zeller G, Huerta-Cepas J, Coelho LP, Bork P:
proGenomes2: an improved database for accurate and consistent habitat, taxonomic and functional annotations of prokaryotic genomes.
Nucleic Acids Res. 2020 Jan 8;48(D1):D621-D625. doi: 10.1093/nar/gkz1002. PMID: 31647096

Kräker K, O'Driscoll JM, Schütte T, Herse F, Patey O, Golic M, Geisberger S, Verlohren S, Birukov A, Heuser A, Müller DN, Thilaganathan B, Dechend R, Haase N:
Statins Reverse Postpartum Cardiovascular Dysfunction in a Rat Model of Preeclampsia.
Hypertension. 2020 Jan;75(1):202-210. doi: 10.1161/HYPERTENSIONAHA.119.13219. Epub 2019 Dec 2. PMID: 31786987

Holtgrewe M, Stolpe O, Nieminen M, Mundlos S, Knaus A, Kornak U, Seelow D, Segebrecht L, Spielmann M, Fischer-Zirnsak B, Boschann F, Scholl U, Ehmke N, Beule D:
VarFish: comprehensive DNA variant analysis for diagnostics and research.
Nucleic Acids Res. 2020 Jul 2;48(W1):W162-W169. doi: 10.1093/nar/gkaa241. PMID: 32338743

Marvaldi L, Panayotis N, Alber S, Dagan SY, Okladnikov N, Koppel I, Di Pizio A, Song DA, Tzur Y, Terenzio M, Rishal I, Gordon D, Rother F, Hartmann E, Bader M, Fainzilber M:
Importin α3 regulates chronic pain pathways in peripheral sensory neurons.
Science. 2020 Aug 14;369(6505):842-846. doi: 10.1126/science.aaz5875. PMID: 32792398

Polovitskaya MM, Barbini C, Martinelli D, Harms FL, Cole FS, Calligari P, Bocchinfuso G, Stella L, Ciolfi A, Niceta M, Rizza T, Shinawi M, Sisco K, Johannsen J, Denecke J, Carrozzo R, Wegner DJ, Kutsche K, Tartaglia M, Jentsch TJ:
A Recurrent Gain-of-Function Mutation in CLCN6, Encoding the ClC-6 Cl-/H+-Exchanger, Causes Early-Onset Neurodegeneration.
Am J Hum Genet. 2020 Dec 3;107(6):1062-1077. doi: 10.1016/j.ajhg.2020.11.004. Epub 2020 Nov 19. PMID: 33217309
    
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Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.
Immunity. 2020 May 19;52(5):767-781.e6. doi: 10.1016/j.immuni.2020.03.016. Epub 2020 Apr 10. PMID: 32277911

Weinert S, Gimber N, Deuschel D, Stuhlmann T, Puchkov D, Farsi Z, Ludwig CF, Novarino G, López-Cayuqueo KI, Planells-Cases R, Jentsch TJ:
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
EMBO J. 2020 May 4;39(9):e103358. doi: 10.15252/embj.2019103358. Epub 2020 Mar 2. PMID: 32118314

Schrezenmeier E, Dörner T:
Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology.
Nat Rev Rheumatol. 2020 Mar;16(3):155-166. doi: 10.1038/s41584-020-0372-x. Epub 2020 Feb 7. PMID: 32034323

Kaminski MM, Alcantar MA, Lape IT, Greensmith R, Huske AC, Valeri JA, Marty FM, Klämbt V, Azzi J, Akalin E, Riella LV, Collins JJ:
A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection.
Nat Biomed Eng. 2020 Jun;4(6):601-609. doi: 10.1038/s41551-020-0546-5. Epub 2020 Apr 13. PMID: 32284553

Dusek P, Mekle R, Skowronska M, Acosta-Cabronero J, Huelnhagen T, Robinson SD, Schubert F, Deschauer M, Els A, Ittermann B, Schottmann G, Madai VI, Paul F, Klopstock T, Kmiec T, Niendorf T, Wuerfel J, Schneider SA:
Brain iron and metabolic abnormalities in C19orf12 mutation carriers: A 7.0 tesla MRI study in mitochondrial membrane protein-associated neurodegeneration.
Mov Disord. 2020 Jan;35(1):142-150. doi: 10.1002/mds.27827. Epub 2019 Sep 13. PMID: 31518459

Li S, Liu M, Do MH, Chou C, Stamatiades EG, Nixon BG, Shi W, Zhang X, Li P, Gao S, Capistrano KJ, Xu H, Cheung NV, Li MO:
Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells.
Nature. 2020 Nov;587(7832):121-125. doi: 10.1038/s41586-020-2850-3. Epub 2020 Oct 21. PMID: 33087933

Liu M, Kuo F, Capistrano KJ, Kang D, Nixon BG, Shi W, Chou C, Do MH, Stamatiades EG, Gao S, Li S, Chen Y, Hsieh JJ, Hakimi AA, Taniuchi I, Chan TA, Li MO:
TGF-β suppresses type 2 immunity to cancer.
Nature. 2020 Nov;587(7832):115-120. doi: 10.1038/s41586-020-2836-1. Epub 2020 Oct 21. PMID: 33087928

Ostendorf L, Burns M, Durek P, Heinz GA, Heinrich F, Garantziotis P, Enghard P, Richter U, Biesen R, Schneider U, Knebel F, Burmester G, Radbruch A, Mei HE, Mashreghi MF, Hiepe F, Alexander T:
Targeting CD38 with Daratumumab in Refractory Systemic Lupus Erythematosus.
N Engl J Med. 2020 Sep 17;383(12):1149-1155. doi: 10.1056/NEJMoa2023325. PMID: 32937047

Kannen V, Bader M, Sakita JY, Uyemura SA, Squire JA:
The Dual Role of Serotonin in Colorectal Cancer.
Trends Endocrinol Metab. 2020 Aug;31(8):611-625. doi: 10.1016/j.tem.2020.04.008. Epub 2020 May 18. PMID: 32439105

Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, Baqi Y, Müller CE, Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV:
Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors.
Mol Psychiatry. 2020 Aug;25(8):1876-1900. doi: 10.1038/s41380-018-0110-9. Epub 2018 Jun 27. PMID: 29950682

Bader M:
Inhibition of serotonin synthesis: A novel therapeutic paradigm.
Pharmacol Ther. 2020 Jan;205:107423. doi: 10.1016/j.pharmthera.2019.107423. Epub 2019 Oct 17. PMID: 31629717

Hanses U, Kleinsorge M, Roos L, Yigit G, Li Y, Barbarics B, El-Battrawy I, Lan H, Tiburcy M, Hindmarsh R, Lenz C, Salinas G, Diecke S, Müller C, Adham I, Altmüller J, Nürnberg P, Paul T, Zimmermann WH, Hasenfuss G, Wollnik B, Cyganek L:
Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome-Associated Cardiomyopathy.
Circulation. 2020 Sep 15;142(11):1059-1076. doi: 10.1161/CIRCULATIONAHA.119.044794. Epub 2020 Jul 6. PMID: 32623905

Koch C, Kuske A, Joosse SA, Yigit G, Sflomos G, Thaler S, Smit DJ, Werner S, Borgmann K, Gärtner S, Mossahebi Mohammadi P, Battista L, Cayrefourcq L, Altmüller J, Salinas-Riester G, Raithatha K, Zibat A, Goy Y, Ott L, Bartkowiak K, Tan TZ, Zhou Q, Speicher MR, Müller V, Gorges TM, Jücker M, Thiery JP, Brisken C, Riethdorf S, Alix-Panabières C, Pantel K:
Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity.
EMBO Mol Med. 2020 Sep 7;12(9):e11908. doi: 10.15252/emmm.201911908. Epub 2020 Jul 15. PMID: 32667137

Gerbracht JV, Boehm V, Britto-Borges T, Kallabis S, Wiederstein JL, Ciriello S, Aschemeier DU, Krüger M, Frese CK, Altmüller J, Dieterich C, Gehring NH:
CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex.
Nucleic Acids Res. 2020 Sep 4;48(15):8626-8644. doi: 10.1093/nar/gkaa564. PMID: 32621609

Jiang H, Gallet S, Klemm P, Scholl P, Folz-Donahue K, Altmüller J, Alber J, Heilinger C, Kukat C, Loyens A, Müller-Fielitz H, Sundaram S, Schwaninger M, Prevot V, Brüning JC:
MCH Neurons Regulate Permeability of the Median Eminence Barrier.
Neuron. 2020 Jul 22;107(2):306-319.e9. doi: 10.1016/j.neuron.2020.04.020. Epub 2020 May 13.PMID: 32407670

Wang H, Humbatova A, Liu Y, Qin W, Lee M, Cesarato N, Kortüm F, Kumar S, Romano MT, Dai S, Mo R, Sivalingam S, Motameny S, Wu Y, Wang X, Niu X, Geng S, Bornholdt D, Kroisel PM, Tadini G, Walter SD, Hauck F, Girisha KM, Calza AM, Bottani A, Altmüller J, Buness A, Yang S, Sun X, Ma L, Kutsche K, Grzeschik KH, Betz RC, Lin Z:
Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome.
Am J Hum Genet. 2020 Jul 2;107(1):34-45. doi: 10.1016/j.ajhg.2020.05.006. Epub 2020 Jun 3. PMID: 32497488

Erger F, Nörling D, Borchert D, Leenen E, Habbig S, Wiesener MS, Bartram MP, Wenzel A, Becker C, Toliat MR, Nürnberg P, Beck BB, Altmüller J:
cfNOMe - A single assay for comprehensive epigenetic analyses of cell-free DNA.
Genome Med. 2020 Jun 24;12(1):54. doi: 10.1186/s13073-020-00750-5. PMID: 32580754

Pohl-Rescigno E, Hauke J, Loibl S, Möbus V, Denkert C, Fasching PA, Kayali M, Ernst C, Weber-Lassalle N, Hanusch C, Tesch H, Müller V, Altmüller J, Thiele H, Untch M, Lübbe K, Nürnberg P, Rhiem K, Furlanetto J, Lederer B, Jackisch C, Nekljudova V, Schmutzler RK, Schneeweiss A, Hahnen E:
Association of Germline Variant Status With Therapy Response in High-risk Early-Stage Breast Cancer: A Secondary Analysis of the GeparOcto Randomized Clinical Trial.
JAMA Oncol. 2020 May 1;6(5):744-748. doi: 10.1001/jamaoncol.2020.0007. PMID: 32163106

Duerr J, Leitz DHW, Szczygiel M, Dvornikov D, Fraumann SG, Kreutz C, Zadora PK, Seyhan Agircan A, Konietzke P, Engelmann TA, Hegermann J, Mulugeta S, Kawabe H, Knudsen L, Ochs M, Rotin D, Muley T, Kreuter M, Herth FJF, Wielpütz MO, Beers MF, Klingmüller U, Mall MA:
Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice.
Nat Commun. 2020 Apr 24;11(1):2012. doi: 10.1038/s41467-020-15743-6. PMID: 32332792

Johnsen M, Kubacki T, Yeroslaviz A, Späth MR, Mörsdorf J, Göbel H, Bohl K, Ignarski M, Meharg C, Habermann B, Altmüller J, Beyer A, Benzing T, Schermer B, Burst V, Müller RU:
The Integrated RNA Landscape of Renal Preconditioning against Ischemia-Reperfusion Injury.
J Am Soc Nephrol. 2020 Apr;31(4):716-730. doi: 10.1681/ASN.2019050534. Epub 2020 Feb 28. PMID: 32111728

Goulielmaki E, Ioannidou A, Tsekrekou M, Stratigi K, Poutakidou IK, Gkirtzimanaki K, Aivaliotis M, Evangelou K, Topalis P, Altmüller J, Gorgoulis VG, Chatzinikolaou G, Garinis GA:
Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage.
Nat Commun. 2020 Jan 2;11(1):42. doi: 10.1038/s41467-019-13894-9. PMID: 31896748

Di Maio S, Grüneis R, Streiter G, Lamina C, Maglione M, Schoenherr S, Öfner D, Thorand B, Peters A, Eckardt KU, Köttgen A, Kronenberg F, Coassin S:
Investigation of a nonsense mutation located in the complex KIV-2 copy number variation region of apolipoprotein(a) in 10,910 individuals.
Genome Med. 2020 Aug 21;12(1):74. doi: 10.1186/s13073-020-00771-0. PMID: 32825847

Kespohl M, Bredow C, Klingel K, Voß M, Paeschke A, Zickler M, Poller W, Kaya Z, Eckstein J, Fechner H, Spranger J, Fähling M, Wirth EK, Radoshevich L, Thery F, Impens F, Berndt N, Knobeloch KP, Beling A:
Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming.
Sci Adv. 2020 Mar 11;6(11):eaay1109. doi: 10.1126/sciadv.aay1109. eCollection 2020 Mar. PMID: 32195343

Arends CM, Weiss M, Christen F, Eulenberg-Gustavus C, Rousselle A, Kettritz R, Eckardt KU, Chan W, Hoyer K, Frick M, Bullinger L, Bieringer M, Schreiber A, Damm F:
Clonal hematopoiesis in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.
Haematologica. 2020 Jun;105(6):e264-e267. doi: 10.3324/haematol.2019.223305. Epub 2019 Oct 3. PMID: 31582546

Neubert P, Weichselbaum A, Reitinger C, Schatz V, Schröder A, Ferdinand JR, Simon M, Bär AL, Brochhausen C, Gerlach RG, Tomiuk S, Hammer K, Wagner S, van Zandbergen G, Binger KJ, Müller DN, Kitada K, Clatworthy MR, Kurts C, Titze J, Abdullah Z, Jantsch J:
HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.
Autophagy. 2019 Nov;15(11):1899-1916. doi: 10.1080/15548627.2019.1596483. Epub 2019 Apr 14. PMID: 30982460

Binger KJ, Neukam M, Tattikota SG, Qadri F, Puchkov D, Willmes DM, Wurmsee S, Geisberger S, Dechend R, Raile K, Kurth T, Nguyen G, Poy MN, Solimena M, Muller DN, Birkenfeld AL:
Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells.
Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):19983-19988. doi: 10.1073/pnas.1903678116. Epub 2019 Sep 16. PMID: 31527264

Glover N, Dessimoz C, Ebersberger I, Forslund SK, Gabaldón T, Huerta-Cepas J, Martin MJ, Muffato M, Patricio M, Pereira C, da Silva AS, Wang Y, Sonnhammer E, Thomas PD:
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Mol Biol Evol. 2019 Oct 1;36(10):2157-2164. doi: 10.1093/molbev/msz150. PMID: 31241141

Hildebrand F, Moitinho-Silva L, Blasche S, Jahn MT, Gossmann TI, Huerta-Cepas J, Hercog R, Luetge M, Bahram M, Pryszlak A, Alves RJ, Waszak SM, Zhu A, Ye L, Costea PI, Aalvink S, Belzer C, Forslund SK, Sunagawa S, Hentschel U, Merten C, Patil KR, Benes V, Bork P:
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Gut. 2019 Oct;68(10):1781-1790. doi: 10.1136/gutjnl-2018-317715. Epub 2019 Jan 18. PMID: 30658995

Wilck N, Balogh A, Markó L, Bartolomaeus H, Müller DN:
The role of sodium in modulating immune cell function.
Nat Rev Nephrol. 2019 Sep;15(9):546-558. doi: 10.1038/s41581-019-0167-y. Epub 2019 Jun 25. PMID: 31239546

Birukov A, Andersen LB, Herse F, Rakova N, Kitlen G, Kyhl HB, Golic M, Haase N, Kräker K, Müller DN, Jørgensen JS, Andersen MS, Dechend R, Jensen BL:
Aldosterone, Salt, and Potassium Intakes as Predictors of Pregnancy Outcome, Including Preeclampsia.
Hypertension. 2019 Aug;74(2):391-398. doi: 10.1161/HYPERTENSIONAHA.119.12924. Epub 2019 Jun 10. PMID: 31177907

Bartolomaeus H, Markó L, Wilck N, Luft FC, Forslund SK, Muller DN:
Precarious Symbiosis Between Host and Microbiome in Cardiovascular Health.
Hypertension. 2019 May;73(5):926-935. doi: 10.1161/HYPERTENSIONAHA.119.11786. PMID: 30905198

Huerta-Cepas J, Szklarczyk D, Heller D, Hernández-Plaza A, Forslund SK, Cook H, Mende DR, Letunic I, Rattei T, Jensen LJ, von Mering C, Bork P:
eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses.
Nucleic Acids Res. 2019 Jan 8;47(D1):D309-D314. doi: 10.1093/nar/gky1085. PMID: 30418610

Hill J, Enbody ED, Pettersson ME, Sprehn CG, Bekkevold D, Folkvord A, Laikre L, Kleinau G, Scheerer P, Andersson L:
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Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18473-18478. doi: 10.1073/pnas.1908332116. Epub 2019 Aug 26. PMID: 31451650

Veronez CL, Maghsodi S, Todiras M, Popova E, Rodrigues AF, Qadri F, Pesquero JB, Bader M:
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Allergy. 2019 Oct;74(10):1998-2002. doi: 10.1111/all.13836. Epub 2019 Jun 28. PMID: 31004495

Omar F, Findlay JE, Carfray G, Allcock RW, Jiang Z, Moore C, Muir AL, Lannoy M, Fertig BA, Mai D, Day JP, Bolger G, Baillie GS, Schwiebert E, Klussmann E, Pyne NJ, Ong ACM, Bowers K, Adam JM, Adams DR, Houslay MD, Henderson DJP:
Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.
Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329. doi: 10.1073/pnas.1822113116. Epub 2019 Jun 17. PMID: 31209056

Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H 3rd, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I:
Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.
Nature. 2019 Mar;567(7749):535-539. doi: 10.1038/s41586-019-1024-7. Epub 2019 Mar 13

Ostermann AL, Wunderlich CM, Schneiders L, Vogt MC, Woeste MA, Belgardt BF, Niessen CM, Martiny B, Schauss AC, Frommolt P, Nikolaev A, Hövelmeyer N, Sears RC, Koch PJ, Günzel D, Brüning JC, Wunderlich FT:
Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer.
Nat Metab. 2019 Mar;1(3):371-389. doi: 10.1038/s42255-019-0037-8. Epub 2019 Mar 4. PMID: 32694718

Živanović V, Seifert S, Drescher D, Schrade P, Werner S, Guttmann P, Szekeres GP, Bachmann S, Schneider G, Arenz C, Kneipp J:
Optical Nanosensing of Lipid Accumulation due to Enzyme Inhibition in Live Cells.
ACS Nano. 2019 Aug 27;13(8):9363-9375. doi: 10.1021/acsnano.9b04001. Epub 2019 Jul 22. PMID: 31314989

Berrien-Elliott MM, Sun Y, Neal C, Ireland A, Trissal MC, Sullivan RP, Wagner JA, Leong JW, Wong P, Mah-Som AY, Wong TN, Schappe T, Keppel CR, Cortez VS, Stamatiades EG, Li MO, Colonna M, Link DC, French AR, Cooper MA, Wang WL, Boldin MP, Reddy P, Fehniger TA:
MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells.
Immunity. 2019 Sep 17;51(3):479-490.e6. doi: 10.1016/j.immuni.2019.06.016. Epub 2019 Aug 8. PMID: 31402259

Stamatiades EG, Li MO:
Tissue-resident cytotoxic innate lymphoid cells in tumor immunosurveillance.
Semin Immunol. 2019 Feb;41:101269. doi: 10.1016/j.smim.2019.03.001. Epub 2019 Mar 21. PMID: 30904283

Mann N, Kause F, Henze EK, Gharpure A, Shril S, Connaughton DM, Nakayama M, Klämbt V, Majmundar AJ, Wu CW, Kolvenbach CM, Dai R, Chen J, van der Ven AT, Ityel H, Tooley MJ, Kari JA, Bownass L, El Desoky S, De Franco E, Shalaby M, Tasic V, Bauer SB, Lee RS, Beckel JM, Yu W, Mane SM, Lifton RP, Reutter H, Ellard S, Hibbs RE, Kawate T, Hildebrandt F:
CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations.
Am J Hum Genet. 2019 Dec 5;105(6):1286-1293. doi: 10.1016/j.ajhg.2019.10.004. Epub 2019 Nov 7. PMID: 31708116

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De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry.
Am J Hum Genet. 2019 Nov 7;105(5):1030-1039. doi: 10.1016/j.ajhg.2019.09.022. Epub 2019 Oct 17. PMID: 31630787

Jurkute N, Leu C, Pogoda HM, Arno G, Robson AG, Nürnberg G, Altmüller J, Thiele H, Motameny S, Toliat MR, Powell K, Höhne W, Michaelides M, Webster AR, Moore AT, Hammerschmidt M, Nürnberg P, Yu-Wai-Man P, Votruba M:
SSBP1 mutations in dominant optic atrophy with variable retinal degeneration.
Ann Neurol. 2019 Sep;86(3):368-383. doi: 10.1002/ana.25550. Epub 2019 Jul 31. PMID: 31298765

Murakami Y, Nguyen TTM, Baratang N, Raju PK, Knaus A, Ellard S, Jones G, Lace B, Rousseau J, Ajeawung NF, Kamei A, Minase G, Akasaka M, Araya N, Koshimizu E, van den Ende J, Erger F, Altmüller J, Krumina Z, Strautmanis J, Inashkina I, Stavusis J, El-Gharbawy A, Sebastian J, Puri RD, Kulshrestha S, Verma IC, Maier EM, Haack TB, Israni A, Baptista J, Gunning A, Rosenfeld JA, Liu P, Joosten M, Rocha ME, Hashem MO, Aldhalaan HM, Alkuraya FS, Miyatake S, Matsumoto N, Krawitz PM, Rossignol E, Kinoshita T, Campeau PM:
Mutations in PIGB Cause an Inherited GPI Biosynthesis Defect with an Axonal Neuropathy and Metabolic Abnormality in Severe Cases.
Am J Hum Genet. 2019 Aug 1;105(2):384-394. doi: 10.1016/j.ajhg.2019.05.019. Epub 2019 Jun 27. PMID: 31256876

Bauer CK, Schneeberger PE, Kortüm F, Altmüller J, Santos-Simarro F, Baker L, Keller-Ramey J, White SM, Campeau PM, Gripp KW, Kutsche K:
Gain-of-Function Mutations in KCNN3 Encoding the Small-Conductance Ca2+-Activated K+ Channel SK3 Cause Zimmermann-Laband Syndrome.
Am J Hum Genet. 2019 Jun 6;104(6):1139-1157. doi: 10.1016/j.ajhg.2019.04.012. Epub 2019 May 30. PMID: 31155282

Kolvenbach CM, Dworschak GC, Frese S, Japp AS, Schuster P, Wenzlitschke N, Yilmaz Ö, Lopes FM, Pryalukhin A, Schierbaum L, van der Zanden LFM, Kause F, Schneider R, Taranta-Janusz K, Szczepańska M, Pawlaczyk K, Newman WG, Beaman GM, Stuart HM, Cervellione RM, Feitz WFJ, van Rooij IALM, Schreuder MF, Steffens M, Weber S, Merz WM, Feldkötter M, Hoppe B, Thiele H, Altmüller J, Berg C, Kristiansen G, Ludwig M, Reutter H, Woolf AS, Hildebrandt F, Grote P, Zaniew M, Odermatt B, Hilger AC:
Rare Variants in BNC2 Are Implicated in Autosomal-Dominant Congenital Lower Urinary-Tract Obstruction.
Am J Hum Genet. 2019 May 2;104(5):994-1006. doi: 10.1016/j.ajhg.2019.03.023. PMID: 31051115

Schneider JP, Wrede C, Hegermann J, Weibel ER, Mühlfeld C, Ochs M:
On the Topological Complexity of Human Alveolar Epithelial Type 1 Cells.
Am J Respir Crit Care Med. 2019 May 1;199(9):1153-1156. doi: 10.1164/rccm.201810-1866LE. PMID: 30758981

Wagener R, Seufert J, Raimondi F, Bens S, Kleinheinz K, Nagel I, Altmüller J, Thiele H, Hübschmann D, Kohler CW, Nürnberg P, Au-Yeung R, Burkhardt B, Horn H, Leoncini L, Jaffe ES, Ott G, Rymkiewicz G, Schlesner M, Russell RB, Klapper W, Siebert R:
The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma.
Blood. 2019 Feb 28;133(9):962-966. doi: 10.1182/blood-2018-07-864025. Epub 2018 Dec 19. PMID: 30567752

Sawitzki B:
MAIT Cells as Drivers of Renal Fibrosis and CKD.
J Am Soc Nephrol. 2019 Jul;30(7):1145-1146. doi: 10.1681/ASN.2019050468. Epub 2019 Jun 11. PMID: 31253730

Truong KL, Schlickeiser S, Vogt K, Boës D, Stanko K, Appelt C, Streitz M, Grütz G, Stobutzki N, Meisel C, Iwert C, Tomiuk S, Polansky JK, Pascher A, Babel N, Stervbo U, Sauer I, Gerlach U, Sawitzki B:
Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells.
Nat Commun. 2019 May 22;10(1):2263. doi: 10.1038/s41467-019-10018-1. PMID: 31118448

Teumer A, Li Y, Ghasemi S, Prins BP, Wuttke M, Hermle T, Giri A, Sieber KB, Qiu C, Kirsten H, Tin A, Chu AY, Bansal N, Feitosa MF, Wang L, Chai JF, Cocca M, Fuchsberger C, Gorski M, Hoppmann A, Horn K, Li M, Marten J, Noce D, Nutile T, Sedaghat S, Sveinbjornsson G, Tayo BO, van der Most PJ, Xu Y, Yu Z, Gerstner L, Ärnlöv J, Bakker SJL, Baptista D, Biggs ML, Boerwinkle E, Brenner H, Burkhardt R, Carroll RJ, Chee ML, Chee ML, Chen M, Cheng CY, Cook JP, Coresh J, Corre T, Danesh J, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Dittrich K, Divers J, Eckardt KU, Ehret G, Endlich K, Felix JF, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Gansevoort RT, Giedraitis V, Gögele M, Grundner-Culemann F, Gudbjartsson DF, Gudnason V, Hamet P, Harris TB, Hicks AA, Holm H, Foo VHX, Hwang SJ, Ikram MA, Ingelsson E, Jaddoe VWV, Jakobsdottir J, Josyula NS, Jung B, Kähönen M, Khor CC, Kiess W, Koenig W, Körner A, Kovacs P, Kramer H, Krämer BK, Kronenberg F, Lange LA, Langefeld CD, Lee JJ, Lehtimäki T, Lieb W, Lim SC, Lind L, Lindgren CM, Liu J, Loeffler M, Lyytikäinen LP, Mahajan A, Maranville JC, Mascalzoni D, McMullen B, Meisinger C, Meitinger T, Miliku K, Mook-Kanamori DO, Müller-Nurasyid M, Mychaleckyj JC, Nauck M, Nikus K, Ning B, Noordam R, Connell JO, Olafsson I, Palmer ND, Peters A, Podgornaia AI, Ponte B, Poulain T, Pramstaller PP, Rabelink TJ, Raffield LM, Reilly DF, Rettig R, Rheinberger M, Rice KM, Rivadeneira F, Runz H, Ryan KA, Sabanayagam C, Saum KU, Schöttker B, Shaffer CM, Shi Y, Smith AV, Strauch K, Stumvoll M, Sun BB, Szymczak S, Tai ES, Tan NYQ, Taylor KD, Teren A, Tham YC, Thiery J, Thio CHL, Thomsen H, Thorsteinsdottir U, Tönjes A, Tremblay J, Uitterlinden AG, van der Harst P, Verweij N, Vogelezang S, Völker U, Waldenberger M, Wang C, Wilson OD, Wong C, Wong TY, Yang Q, Yasuda M, Akilesh S, Bochud M, Böger CA, Devuyst O, Edwards TL, Ho K, Morris AP, Parsa A, Pendergrass SA, Psaty BM, Rotter JI, Stefansson K, Wilson JG, Susztak K, Snieder H, Heid IM, Scholz M, Butterworth AS, Hung AM, Pattaro C, Köttgen A:
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.
Nat Commun. 2019 Sep 11;10(1):4130. doi: 10.1038/s41467-019-11576-0. PMID: 31511532

Thiele A, Luettges K, Ritter D, Beyhoff N, Smeir E, Grune J, Steinhoff JS, Schupp M, Klopfleisch R, Rothe M, Wilck N, Bartolomaeus H, Migglautsch AK, Breinbauer R, Kershaw EE, Grabner GF, Zechner R, Kintscher U, Foryst-Ludwig A:
Pharmacological inhibition of adipose tissue adipose triglyceride lipase by Atglistatin prevents catecholamine-induced myocardial damage.
Cardiovasc Res. 2022 Aug 24;118(11):2488-2505. doi: 10.1093/cvr/cvab182.PMID: 34061169

Mansour F, Hinze C, Telugu NS, Kresoja J, Shaheed IB, Mosimann C, Diecke S, Schmidt-Ott KM:
The centrosomal protein 83 (CEP83) regulates human pluripotent stem cell differentiation towards the kidney lineage.
Elife. 2022 Oct 12;11:e80165. doi: 10.7554/eLife.80165. Online ahead of print.PMID: 36222666

Nemec K, Schihada H, Kleinau G, Zabel U, Grushevskyi EO, Scheerer P, Lohse MJ, Maiellaro I:
Functional modulation of PTH1R activation and signaling by RAMP2.
Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2122037119. doi: 10.1073/pnas.2122037119. Epub 2022 Aug 1.PMID: 35914163

Wang X, Jiang S, Fei L, Dong F, Xie L, Qiu X, Lei Y, Guo J, Zhong M, Ren X, Yang Y, Zhao L, Zhang G, Wang H, Tang C, Yu L, Liu R, Patzak A, Persson PB, Hultström M, Wei Q, Lai EY, Zheng Z:
Tacrolimus Causes Hypertension by Increasing Vascular Contractility via RhoA (Ras Homolog Family Member A)/ROCK (Rho-Associated Protein Kinase) Pathway in Mice.
Hypertension. 2022 Oct;79(10):2228-2238. doi: 10.1161/HYPERTENSIONAHA.122.19189. Epub 2022 Aug 8.PMID: 35938417

Cantow K, Gladytz T, Millward JM, Waiczies S, Niendorf T, Seeliger E:
Monitoring kidney size to interpret MRI-based assessment of renal oxygenation in acute pathophysiological scenarios.
Acta Physiol (Oxf). 2022 Aug 22:e13868. doi: 10.1111/apha.13868. Online ahead of print.PMID: 35993768

Whelton PK, Carey RM, Mancia G, Kreutz R, Bundy JD, Williams B:
Harmonization of the American College of Cardiology/American Heart Association and European Society of Cardiology/European Society of Hypertension Blood Pressure/Hypertension Guidelines: Comparisons, Reflections, and Recommendations.
J Am Coll Cardiol. 2022 Sep 20;80(12):1192-1201. doi: 10.1016/j.jacc.2022.07.005. Epub 2022 Aug 11.PMID: 35965201

Hinrichs GR, Baltzer S, Pallien T, Svenningsen P, Dalgaard EB, Hertz JM, Bistrup C, Jensen BL, Klussmann E:
A Novel AQP2 Sequence Variant Causing Aquaporin-2 Retention in the Cytoplasm and Autosomal Dominant Nephrogenic Diabetes Insipidus.
Kidney Int Rep. 2022 Jul 12;7(10):2289-2294. doi: 10.1016/j.ekir.2022.07.001. eCollection 2022 Oct.PMID: 36217530

Castaneda-Vega S, Beer-Hammer S, Leiss V, Napieczyńska H, Vuozzo M, Schmid AM, Zeng H, He Y, Kohlhofer U, Gonzalez-Menendez I, Quintanilla-Martinez L, Hempel JM, Gollasch M, Yu X, Pichler BJ, Nürnberg B:
Cerebrovascular G_i Proteins Protect Against Brain Hypoperfusion and Collateral Failure in Cerebral Ischemia.
Mol Imaging Biol. 2022 Sep 8. doi: 10.1007/s11307-022-01764-8. Online ahead of print.PMID: 36074223

Labes R, Brinkmann L, Kulow VA, Roegner K, Mathia S, Balcerek B, Persson PB, Rosenberger C, Fähling M:
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Kidney Int. 2022 Oct;102(4):750-765. doi: 10.1016/j.kint.2022.04.025. Epub 2022 May 26.PMID: 35643373

Holle J, Bartolomaeus H, Löber U, Behrens F, Bartolomaeus TUP, Anandakumar H, Wimmer MI, Vu DL, Kuhring M, Brüning U, Maifeld A, Geisberger S, Kempa S, Schumacher F, Kleuser B, Bufler P, Querfeld U, Kitschke S, Engler D, Kuhrt LD, Drechsel O, Eckardt KU, Forslund SK, Thürmer A, McParland V, Kirwan JA, Wilck N, Müller D:
Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance.
J Am Soc Nephrol. 2022 Aug 19:ASN.2022030378. doi: 10.1681/ASN.2022030378. Online ahead of print.PMID: 35985814

Klocke J, Kim SJ, Skopnik CM, Hinze C, Boltengagen A, Metzke D, Grothgar E, Prskalo L, Wagner L, Freund P, Görlich N, Muench F, Schmidt-Ott KM, Mashreghi MF, Kocks C, Eckardt KU, Rajewsky N, Enghard P:
Urinary single-cell sequencing captures kidney injury and repair processes in human acute kidney injury.
Kidney Int. 2022 Aug 29:S0085-2538(22)00688-3. doi: 10.1016/j.kint.2022.07.032. Online ahead of print.PMID: 36049643

Krasemann S, Dittmayer C, von Stillfried S, Meinhardt J, Heinrich F, Hartmann K, Pfefferle S, Thies E, von Manitius R, Aschman TAD, Radke J, Osterloh A, Schmid S, Buhl EM, Ihlow J, Dubois F, Arnhold V, Elezkurtaj S, Horst D, Hocke A, Timm S, Bachmann S, Corman V, Goebel HH, Matschke J, Stanelle-Bertram S, Gabriel G, Seilhean D, Adle-Biassette H, Ondruschka B, Ochs M, Stenzel W, Heppner FL, Boor P, Radbruch H, Laue M, Glatzel M:
Assessing and improving the validity of COVID-19 autopsy studies - A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analyses.
EBioMedicine. 2022 Sep;83:104193. doi: 10.1016/j.ebiom.2022.104193. Epub 2022 Aug 2.PMID: 35930888

Hinze C, Kocks C, Leiz J, Karaiskos N, Boltengagen A, Cao S, Skopnik CM, Klocke J, Hardenberg JH, Stockmann H, Gotthardt I, Obermayer B, Haghverdi L, Wyler E, Landthaler M, Bachmann S, Hocke AC, Corman V, Busch J, Schneider W, Himmerkus N, Bleich M, Eckardt KU, Enghard P, Rajewsky N, Schmidt-Ott KM:
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Genome Med. 2022 Sep 9;14(1):103. doi: 10.1186/s13073-022-01108-9.PMID: 36085050

Carlson CR, Aronsen JM, Bergan-Dahl A, Moutty MC, Lunde M, Lunde PK, Jarstadmarken H, Wanichawan P, Pereira L, Kolstad TRS, Dalhus B, Subramanian H, Hille S, Christensen G, Müller OJ, Nikolaev V, Bers DM, Sjaastad I, Shen X, Louch WE, Klussmann E, Sejersted OM:
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR.
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Ye Q, Lan B, Liu H, Persson PB, Lai EY, Mao J:
A critical role of the podocyte cytoskeleton in the pathogenesis of glomerular proteinuria and autoimmune podocytopathies.
Acta Physiol (Oxf). 2022 Aug;235(4):e13850. doi: 10.1111/apha.13850. Epub 2022 Jun 28. PMID: 35716094

Xu M, Lichtenberger FB, Erdoǧan C, Lai E, Persson PB, Patzak A, Khedkar PH:
Nitric Oxide Signalling in Descending Vasa Recta after Hypoxia/Re-Oxygenation.
Int J Mol Sci. 2022 Jun 24;23(13):7016. doi: 10.3390/ijms23137016. PMID: 35806018

Zeziulia M, Blin S, Schmitt FW, Lehmann M, Jentsch TJ:
Proton-gated anion transport governs macropinosome shrinkage.
Nat Cell Biol. 2022 Jun;24(6):885-895. doi: 10.1038/s41556-022-00912-0. Epub 2022 May 19. PMID: 35590106

Zheng Z, Xu Y, Krügel U, Schaefer M, Grune T, Nürnberg B, Köhler MB, Gollasch M, Tsvetkov D, Markó L:
In Vivo Inhibition of TRPC6 by SH045 Attenuates Renal Fibrosis in a New Zealand Obese (NZO) Mouse Model of Metabolic Syndrome.
Int J Mol Sci. 2022 Jun 20;23(12):6870. doi: 10.3390/ijms23126870. PMID: 35743312

Labes R, Brinkmann L, Kulow VA, Roegner K, Mathia S, Balcerek B, Persson PB, Rosenberger C, Fähling M:
Daprodustat prevents cyclosporine-A mediated anemia and peritubular capillary loss.
Kidney Int. 2022 May 26:S0085-2538(22)00375-1. doi: 10.1016/j.kint.2022.04.025. Online ahead of print.PMID: 35643373

Bekassy Z, Lopatko Fagerström I, Bader M, Karpman D:
Crosstalk between the renin-angiotensin, complement and kallikrein-kinin systems in inflammation.
Nat Rev Immunol. 2022 Jul;22(7):411-428. doi: 10.1038/s41577-021-00634-8. Epub 2021 Nov 10. PMID: 34759348

López-Cayuqueo KI, Planells-Cases R, Pietzke M, Oliveras A, Kempa S, Bachmann S, Jentsch TJ:
Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.
J Am Soc Nephrol. 2022 Jul 1:ASN.2021111458. doi: 10.1681/ASN.2021111458. Online ahead of print. PMID: 35777784

Wang C, Polovitskaya MM, Delgado BD, Jentsch TJ, Long SB:
Gating choreography and mechanism of the human proton-activated chloride channel ASOR.
Sci Adv. 2022 Feb 4;8(5):eabm3942. doi: 10.1126/sciadv.abm3942. Epub 2022 Feb 2. PMID: 35108041

Breiderhoff T, Himmerkus N, Meoli L, Fromm A, Sewerin S, Kriuchkova N, Nagel O, Ladilov Y, Krug SM, Quintanova C, Stumpp M, Garbe-Schönberg D, Westernströer U, Merkel C, Brinkhus MA, Altmüller J, Schweiger MR, Müller D, Mutig K, Morawski M, Halbritter J, Milatz S, Bleich M, Günzel D:
Claudin-10a Deficiency Shifts Proximal Tubular Cl- Permeability to Cation Selectivity via Claudin-2 Redistribution.
J Am Soc Nephrol. 2022 Jan 14:ASN.2021030286. doi: 10.1681/ASN.2021030286. Online ahead of print. PMID: 35031570

Jerke U, Eulenberg-Gustavus C, Rousselle A, Nicklin P, Kreideweiss S, Grundl MA, Eickholz P, Nickles K, Schreiber A, Korkmaz B, Kettritz R:
Targeting Cathepsin C in PR3-ANCA Vasculitis.
J Am Soc Nephrol. 2022 May;33(5):936-947. doi: 10.1681/ASN.2021081112. Epub 2022 Mar 15.PMID: 35292437

Rousselle A, Sonnemann J, Amann K, Mildner A, Lodka D, Kling L, Bieringer M, Schneider U, Leutz A, Enghard P, Kettritz R, Schreiber A:
CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis.
Ann Rheum Dis. 2022 Apr 13:annrheumdis-2021-221984. doi: 10.1136/annrheumdis-2021-221984. Online ahead of print.PMID: 35418479

Kirschner KM, Scholz H:
WT1 in Adipose Tissue: From Development to Adult Physiology.
​​​​​​​Front Cell Dev Biol. 2022 Mar 16;10:854120. doi: 10.3389/fcell.2022.854120. eCollection 2022.PMID: 35372335 

Liu Q, Xu Z, Zhao K, Hoge WS, Zhang X, Mei Y, Lu Q, Niendorf T, Feng Y:
Diffusion-weighted magnetic resonance imaging in rat kidney using two-dimensional navigated, interleaved echo-planar imaging at 7.0 T.
​​​​​​​NMR Biomed. 2022 May;35(5):e4652. doi: 10.1002/nbm.4652. Epub 2021 Nov 24.PMID: 34820933

Zhou S, Guo J, Liao X, Zhou Q, Qiu X, Jiang S, Xu N, Wang X, Zhao L, Hu W, Xie L, Xie P, Cui Y, Yang Y, Patzak A, Persson PB, Mao J, Lai EY:
rhADAMTS13 reduces oxidative stress by cleaving VWF in ischaemia/reperfusion-induced acute kidney injury.
​​​​​​​Acta Physiol (Oxf). 2022 Mar;234(3):e13778. doi: 10.1111/apha.13778. Epub 2022 Jan 17.PMID: 34989474

Philippe A, Kleinau G, Gruner JJ, Wu S, Postpieszala D, Speck D, Heidecke H, Dowell SJ, Riemekasten G, Hildebrand PW, Kamhieh-Milz J, Catar R, Szczepek M, Dragun D, Scheerer P:
Molecular Effects of Auto-Antibodies on Angiotensin II Type 1 Receptor Signaling and Cell Proliferation.
​​​​​​​Int J Mol Sci. 2022 Apr 2;23(7):3984. doi: 10.3390/ijms23073984.PMID: 35409344

Scholl UI:
Genetics of Primary Aldosteronism.
Hypertension. 2022 May;79(5):887-897.doi: 10.1161/HYPERTENSIONAHA.121.16498. Epub 2022 Feb 10.PMID: 35139664 

Boeckhaus J, Hoefele J, Riedhammer KM, Nagel M, Beck B, Choi M, Gollasch M, Bergmann C, Sonntag JE, Troesch V, Stock J, Gross O:
Lifelong Effect of Therapy in Young Patients with the COL4A5 Alport Missense Variant p.(Gly624Asp): a Prospective Cohort Study.
Nephrol Dial Transplant. 2022 Jan 12:gfac006. doi: 10.1093/ndt/gfac006. Online ahead of print. PMID: 35022790

Cui Y, Kassmann M, Nickel S, Zhang C, Alenina N, Anistan YM, Schleifenbaum J, Bader M, Welsh DG, Huang Y, Gollasch M:
Myogenic Vasoconstriction Requires Canonical G _q/11 Signaling of the Angiotensin II Type 1 Receptor.
J Am Heart Assoc. 2022 Feb 15;11(4):e022070. doi: 10.1161/JAHA.121.022070. Epub 2022 Feb 8. PMID: 35132870.

Yilmaz DE, Kirschner K, Demirci H, Himmerkus N, Bachmann S, Mutig K:
Immunosuppressive calcineurin inhibitor cyclosporine A induces proapoptotic endoplasmic reticulum stress in renal tubular cells.
J Biol Chem. 2022 Jan 14;298(3):101589. doi: 10.1016/j.jbc.2022.101589. Epub ahead of print. PMID: 35033536.

Grabowski K, Herlan L, Witten A, Qadri F, Eisenreich A, Lindner D, Schädlich M, Schulz A, Subrova J, Mhatre KN, Primessnig U, Plehm R,
van Linthout S, Escher F, Bader M, Stoll M, Westermann D, Heinzel FR, Kreutz R:
Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
Hypertens Res. 2022 Feb;45(2):292-307. doi: 10.1038/s41440-021-00826-8. Epub 2021 Dec 16. PMID: 34916661.

Catar RA, Wischnewski O, Chen L, Heidecke H, Rutz C, Schülein R, Dragun D,Philippe A, Kusch A:
Non-HLA antibodies targeting angiotensin II Type 1 receptor and endothelin-1 Type A receptors induce endothelial injury via β2-arrestin link
to mTOR pathway.
Kidney Int. 2022 Mar;101(3):498-509. doi: 10.1016/j.kint.2021.09.029. Epub 2021 Oct 29. PMID: 34757123.

Fromentin S, Forslund SK, Chechi K, Aron-Wisnewsky J, Chakaroun R, Nielsen T, Tremaroli V, Ji B, Prifti E, Myridakis A, Chilloux J, Andrikopoulos P, Fan Y, Olanipekun MT, Alves R, Adiouch S, Bar N, Talmor-Barkan Y, Belda E, Caesar R, Coelho LP, Falony G, Fellahi S, Galan P, Galleron N, Helft G, Hoyles L, Isnard R, Le Chatelier E, Julienne H, Olsson L, Pedersen HK, Pons N, Quinquis B, Rouault C, Roume H, Salem JE, Schmidt TSB, Vieira-Silva S, Li P, Zimmermann-Kogadeeva M, Lewinter C, Søndertoft NB, Hansen TH, Gauguier D, Gøtze JP, Køber L, Kornowski R, Vestergaard H, Hansen T, Zucker JD, Hercberg S, Letunic I, Bäckhed F, Oppert JM, Nielsen J, Raes J, Bork P, Stumvoll M, Segal E, Clément K, Dumas ME, Ehrlich SD, Pedersen O:
Microbiome and metabolome features of the cardiometabolic disease spectrum.
Nat Med. 2022 Feb;28(2):303-314. doi: 10.1038/s41591-022-01688-4. Epub 2022 Feb 17. PMID: 35177860.

Zheng Z, Tsvetkov D, Bartolomaeus TUP, Erdogan C, Krügel U, Schleifenbaum J, Schaefer M, Nürnberg B, Chai X, Ludwig FA, N'diaye G, Köhler MB, Wu K, Gollasch M, Markó L:
Role of TRPC6 in kidney damage after acute ischemic kidney injury.
Sci Rep. 2022 Feb 22;12(1):3038. doi: 10.1038/s41598-022-06703-9. PMID: 35194063.

Walker-Gray R, Pallien T, Miller DC, Oder A, Neuenschwander M, von Kries JP, Diecke S, Klussmann E:
Disruptors of AKAP-Dependent Protein-Protein Interactions.
Methods Mol Biol. 2022;2483:117-139. doi: 10.1007/978-1-0716-2245-2_8.PMID: 35286673

Baltzer S, Bulatov T, Schmied C, Krämer A, Berger BT, Oder A, Walker-Gray R, Kuschke C, Zühlke K, Eichhorst J, Lehmann M, Knapp S, Weston J, von Kries JP, Süssmuth RD, Klussmann E:
Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells.
Int J Mol Sci. 2022 Jan 11;23(2):763. doi: 10.3390/ijms23020763.PMID: 35054947.

Subrova J, Böhme K, Gillespie A, Orphal M, Plum C, Kreutz R, Eisenreich A:
MiRNA-29b and miRNA-497 Modulate the Expression of Carboxypeptidase X Member 2, a Candidate Gene Associated with Left Ventricular Hypertrophy.
Int J Mol Sci. 2022 Feb 18;23(4):2263. doi: 10.3390/ijms23042263.PMID: 35216380.

Delgado PR, Kuehne A, Aravina M, Millward JM, Vázquez A, Starke L, Waiczies H, Pohlmann A, Niendorf T, Waiczies S:
B ₁ inhomogeneity correction of RARE MRI at low SNR: Quantitative in vivo ¹⁹ F MRI of mouse neuroinflammation with a cryogenically-cooled transceive surface radiofrequency probe.
Magn Reson Med. 2022 Apr;87(4):1952-1970. doi: 10.1002/mrm.29094. Epub 2021 Nov 23.PMID: 34812528.

Speck D, Kleinau G, Meininghaus M, Erbe A, Einfeldt A, Szczepek M, Scheerer P, Pütter V:
Expression and Characterization of Relaxin Family Peptide Receptor 1 Variants.
Front Pharmacol. 2022 Jan 28;12:826112. doi: 10.3389/fphar.2021.826112. eCollection 2021.PMID: 35153771.

Voss M, Kleinau G, Gimber N, Janek K, Bredow C, Thery F, Impens F, Schmoranzer J, Scheerer P, Kloetzel PM, Beling A:
A cytosolic disulfide bridge-supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A.
FEBS J. 2022 Jan 23. doi: 10.1111/febs.16368. Online ahead of print.PMID: 35066984.

van Thiel BS, van der Linden J, Ridwan Y, Garrelds IM, Vermeij M, Clahsen-van Groningen MC, Qadri F, Alenina N, Bader M, Roks AJM, Danser AHJ, Essers J, van der Pluijm I:
In Vivo Renin Activity Imaging in the Kidney of Progeroid Ercc1 Mutant Mice.
Int J Mol Sci. 2021 Nov 18;22(22):12433. doi: 10.3390/ijms222212433. PMID: 34830315

Zhong C, Xu M, Boral S, Summer H, Lichtenberger FB, Erdoğan C, Gollasch M, Golz S, Persson PB, Schleifenbaum J, Patzak A, Khedkar PH:
Age Impairs Soluble Guanylyl Cyclase Function in Mouse Mesenteric Arteries.
Int J Mol Sci. 2021 Oct 22;22(21):11412. doi: 10.3390/ijms222111412. PMID: 34768842

Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA:
Diagnosis and treatment of primary aldosteronism.
Lancet Diabetes Endocrinol. 2021 Dec;9(12):876-892. doi: 10.1016/S2213-8587(21)00210-2. PMID: 34798068

Zhang G, Han H, Zhuge Z, Dong F, Jiang S, Wang W, Guimarães DD, Schiffer TA, Lai EY, Ribeiro Antonino Carvalho LR, Lucena RB, Braga VA, Weitzberg E, Lundberg JO, Carlstrom M:
Renovascular effects of inorganic nitrate following ischemia-reperfusion of the kidney.
Redox Biol. 2021 Feb;39:101836. doi: 10.1016/j.redox.2020.101836. Epub 2020 Dec 17. PMID: 33360353

Coelho LP, Alves R, Del Río ÁR, Myers PN, Cantalapiedra CP, Giner-Lamia J, Schmidt TS, Mende DR, Orakov A, Letunic I, Hildebrand F, Van Rossum T, Forslund SK, Khedkar S, Maistrenko OM, Pan S, Jia L, Ferretti P, Sunagawa S, Zhao XM, Nielsen HB, Huerta-Cepas J, Bork P:
Towards the biogeography of prokaryotic genes
Nature 2021 Dec 15, doi: 10.1038/s41586-021-04233-4 Online ahead of print. PMID: 34912116

Forslund SK, Chakaroun R, Zimmermann-Kogadeeva M, Markó L, Aron-Wisnewsky J, Nielsen T, Moitinho-Silva L, Schmidt TSB, Falony G, Vieira-Silva S, Adriouch S, Alves RJ, Assmann K, Bastard JP, Birkner T, Caesar R, Chilloux J, Coelho LP, Fezeu L, Galleron N, Helft G, Isnard R, Ji B, Kuhn M, Le Chatelier E, Myridakis A, Olsson L, Pons N, Prifti E, Quinquis B, Roume H, Salem JE, Sokolovska N, Tremaroli V, Valles-Colomer M, Lewinter C, Søndertoft NB, Pedersen HK, Hansen TH; MetaCardis Consortium*, Gøtze JP, Køber L, Vestergaard H, Hansen T, Zucker JD, Hercberg S, Oppert JM, Letunic I, Nielsen J, Bäckhed F, Ehrlich SD, Dumas ME, Raes J, Pedersen O, Clément K, Stumvoll M, Bork P:
Combinatorial, additive and dose-dependent drug-microbiome associations
Nature. 2021 Dec;600(7889):500-505. doi: 10.1038/s41586-021-04177-9. Epub 2021 Dec 8. PMID: 34880489

Maier L, Goemans CV, Wirbel J, Kuhn M, Eberl C, Pruteanu M, Müller P, Garcia-Santamarina S, Cacace E, Zhang B, Gekeler C, Banerjee T, Anderson EE, Milanese A, Löber U, Forslund SK, Patil KR, Zimmermann M, Stecher B, Zeller G, Bork P, Typas A:
Unravelling the collateral damage of anitbiotics on gut bacteria
Nature. 2021 Nov;599(7883):120-124. doi: 10.1038/s41586-021-03986-2. Epub 2021 Oct 13. PMID: 34646011

Pinart M, Nimptsch K, Forslund SK, Schlicht K, Gueimonde M, Brigidi P, Turroni S, Ahrens W, Hebestreit A, Wolters M, Dötsch A, Nöthlings U, Oluwagbemigun K, Cuadrat RRC, Schulze MB, Standl M, Schloter M, De Angelis M, Iozzo P, Guzzardi MA, Vlaemynck G, Penders J, Jonkers DMAE, Stemmer M, Chiesa G, Cavalieri D, De Filippo C, Ercolini D, De Filippis F, Ribet D, Achamrah N, Tavolacci MP, Déchelotte P, Bouwman J, Laudes M, Pischon T:
Identification and characterization of human observational studies in nutritional epidemiology on gut microbiomics for joint data analysis
Nutrients. 2021 Sep 21;13(9):3292. doi: 10.3390/nu13093292. PMID: 34579168

Armada-Moreira A, Cizauskas C, Fleury G, Forslund SK, Guthman EM, Hanafiah A, Hope JM, Jayasinghe I, McSweeney D, Young ID:
STEM pride: Perspectives from transgender, nonbinary, and genderqueer scientists
Cell. 2021 Jun 24;184(13):3352-3355. doi: 10.1016/j.cell.2021.05.043. PMID: 34171316

Maifeld A, Bartolomaeus H, Löber U, Avery EG, Steckhan N, Markó L, Wilck N, Hamad I, Šušnjar U, Mähler A, Hohmann C, Chen CY, Cramer H, Dobos G, Lesker TR, Strowig T, Dechend R, Bzdok D, Kleinewietfeld M, Michalsen A, Müller DN, Forslund SK:
Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients
Nat Commun. 2021 Mar 30;12(1):1970. doi: 10.1038/s41467-021-22097-0. PMID: 33785752

Vieira-Silva S, Falony G, Belda E, Nielsen T, Aron-Wisnewsky J, Chakaroun R, Forslund SK, Assmann K, Valles-Colomer M, Nguyen TTD, Proost S, Prifti E, Tremaroli V, Pons N, Le Chatelier E, Andreelli F, Bastard JP, Coelho LP, Galleron N, Hansen TH, Hulot JS, Lewinter C, Pedersen HK, Quinquis B, Rouault C, Roume H, Salem JE, Søndertoft NB, Touch S; MetaCardis Consortium, Dumas ME, Ehrlich SD, Galan P, Gøtze JP, Hansen T, Holst JJ, Køber L, Letunic I, Nielsen J, Oppert JM, Stumvoll M, Vestergaard H, Zucker JD, Bork P, Pedersen O, Bäckhed F, Clément K, Raes J:
Statin therapy is associated with lower prevalence of gut microbiota dysbiosis
Nature. 2020 May;581(7808):310-315. doi: 10.1038/s41586-020-2269-x. Epub 2020 May 6. PMID: 32433607

Mende DR, Letunic I, Maistrenko OM, Schmidt TSB, Milanese A, Paoli L, Hernández-Plaza A, Orakov AN, Forslund SK, Sunagawa S, Zeller G, Huerta-Cepas J, Coelho LP, Bork P:
proGenomes2: an improved database for accurate and consistent habitat, taxonomic and functional annotations of prokaryotic genomes
Nucleic Acids Res. 2020 Jan 8;48(D1):D621-D625. doi: 10.1093/nar/gkz1002. PMID: 31647096

Liu Q, Xu Z, Zhao K, Hoge WS, Zhang X, Mei Y, Lu Q, Niendorf T, Feng Y:
Diffusion-weighted magnetic resonance imaging in rat kidney using two-dimensional navigated, interleaved echo-planar imaging at 7.0 T
NMR Biomed. 2021 Nov 24:e4652. doi: 10.1002/nbm.4652.PMID: 34820933

Pfau A, Grujic D, Keddis MT, Kausz AT, Lieske JC, Knauf F:
Pilot study of reloxaliase in patients with severe enteric hyperoxaluria and hyperoxalemia
Nephrol Dial Transplant. 2021 Apr 26;36(5):945-948. doi: 10.1093/ndt/gfaa379.PMID: 33416876; PMCID: PMC8075375.

Pfau A, Ermer T, Coca SG, Tio MC, Genser B, Reichel M, Finkelstein FO, März W, Wanner C, Waikar SS, Eckardt KU, Aronson PS, Drechsler C, Knauf F:
High Oxalate Concentrations Correlate with Increased Risk for Sudden Cardiac Death in Dialysis Patients
J Am Soc Nephrol. 2021 Sep;32(9):2375-2385. doi:10.1681/ASN.2020121793. Epub 2021 Jul 19. PMID: 34281958.

Jerome NP, Periquito JS:
Analysis of Renal Diffusion-Weighted Imaging (DWI) Using Apparent Diffusion Coefficient (ADC) and Intravoxel Incoherent Motion (IVIM) Models
Methods Mol Biol 2021;2216:611-635.PMID: 33476027

Alves DT, Mendes LF, Sampaio WO, Coimbra-Campos LMC, Vieira MAR, Ferreira AJ, Martins AS, Popova E, Todiras M, Qadri F, Alenina N, Bader M, Santos RAS, Campagnole-Santos MJ:
Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein
Clin Sci (Lond). 2021 Sep 30;135(18):2197-2216

Schütte T, Kedziora SM, Haase N, Herse F, Alenina N, Müller DN, Bader M, Schupp M, Dechend R, Golic M, Kräker K:
Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring-the heart as a target for fetal programming in rats
Diabetologia. 2021 Sep 18. doi: 10.1007/s00125-021-05566-5

Marins FR, Oliveira AC, Qadri F, Motta-Santos D, Alenina N, Bader M, Fontes MAP, Souza SR:
Alamandine but not angiotensin-(1-7) produces cardiovascular effects at the rostral insular cortex
Am J Physiol Regul Integr Comp Physiol 2021, 321(3):R513-R521 PMID: 34346721

Bekassy Z, Fagerström IL, Bader M, Karpman D:
Crosstalk between the renin-angiotensin, complement and kallikrein-kinin systems in inflammation
Nat Rev Immunol 2021, in press. PMID: 34759348

Jiang S, Shui Y, Cui Y, Tang C, Wang X, Qiu X, Hu W, Fei L, Li Y, Zhang S, Zhao L, Xu N, Dong F, Ren X, Liu R, Persson PB, Patzak A, Lai EY, Wei Q, Zheng Z:
Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II-induced hypertension
Redox Biol. 2021 Oct;46:102115. doi: 10.1016/j.redox.2021.102115. Epub 2021 Aug 25. PMID: 34474396

Stehle D, Xu MZ, Schomber T, Hahn MG, Schweda F, Feil S, Kraehling JR, Eitner F, Patzak A, Sandner P, Feil R, Bénardeau A:
Novel soluble guanylyl cyclase activators increase glomerular cGMP, induce vasodilation and improve blood flow in the murine kidney
Br J Pharmacol . 2021 Jun 7.d oi: 10.1111/bph.15586.PMID: 34096053

Rodrigues AF, Todiras M, Qadri F, Campagnole-Santos MJ, Alenina N, Bader M:
Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis
Clin Sci (Lond). 2021 Jun 11;135(11):1353-1367. DOI: 10.1042/CS20210072 PMID: 34013320

Hardenberg JB, Stockmann H, Aigner A, Gotthardt I, Enghard P, Hinze C, Balzer F, Schmidt D, Zickler D, Kruse J, Körner R, Stegemann M, Schneider T, Schumann M, Müller-Redetzky H, Angermair S, Budde K, Weber-Carstens S, Witzenrath M, Treskatsch S, Siegmund B, Spies C, Suttorp N, Rauch G, Eckardt KU, Schmidt-Ott KM:
Critical Illness and Systemic Inflammation Are Key Risk Factors of Severe Acute Kidney Injury in Patients With COVID-19
Kidney Int Rep. 2021 Apr;6(4):905-915. DOI: 10.1016/j.ekir.2021.01.011 PMID: 33817450

Hinze C, Karaiskos N, Boltengagen A, Walentin K, Redo K, Himmerkus N, Bleich M, Potter SS, Potter AS, Eckardt KU, Kocks C, Rajewsky N, Schmidt-Ott KM:
Kidney Single-cell Transcriptomes Predict Spatial Corticomedullary Gene Expression and Tissue Osmolality Gradients
J Am Soc Nephrol. 2021 Feb;32(2):291-306. DOI: 10.1681/ASN.2020070930 PMID: 33239393

Seidel E, Schewe J, Zhang J, Dinh HA, Forslund SK, Markó L, Hellmig N, Peters J, Muller DN, Lifton RP, Nottoli T, Stölting G, Scholl UI:
Enhanced Ca 2+ signaling, mild primary aldosteronism, and hypertension in a familial hyperaldosteronism mouse model ( Cacna1h M1560V/+ )
Proc Natl Acad Sci U S A. 2021 Apr 27 DOI: 10.1073/pnas.2014876118 PMID: 33879608

Geisberger S, Bartolomaeus H, Neubert P, Willebrand R, Zasada C, Bartolomaeus T, McParland V, Swinnen D, Geuzens A, Maifeld A, Krampert L, Vogl M, Mähler A, Wilck N, Marko L, Tilic E, Forslund SK, Binger KJ, Stegbauer J, Dechend R, Kleinewietfeld M, Jantsch J, Kempa S, Müller DN:
Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes
Circulation. 2021 Apr 28, DOI: 10.1161/CIRCULATIONAHA.120.052788  PMID: 33906377

Avery EG, Bartolomaeus H, Maifeld A, Marko L, Wiig H, Wilck N, Rosshart SP, Forslund SK, Müller DN:
The Gut Microbiome in Hypertension: Recent Advances and Future Perspectives
Circ Res. 2021 Apr 2, DOI: 10.1161/CIRCRESAHA.121.318065 PMID: 33793332

Bartolomaeus TUP, Birkner T, Bartolomaeus H, Löber U, Avery EG, Mähler A, Weber D, Kochlik B, Balogh A, Wilck N, Boschmann M, Müller DN, Markó L, Forslund SK:
Quantifying technical confounders in microbiome studies
Cardiovasc Res. 2021 Feb 22, DOI: 10.1093/cvr/cvaa128 PMID: 32374853

Katz M, Subramaniam S, Chomsky-Hecht O, Tsemakhovich V, Flockerzi V, Klussmann E, Hirsch JA, Weiss S, Dascal N:
Reconstitution of β-adrenergic regulation of Ca V 1.2: Rad-dependent and Rad-independent protein kinase A mechanisms
Proc Natl Acad Sci U S A. 2021 May 25, DOI: 10.1073/pnas.2100021118  PMID: 34001616

Sholokh A, Klussmann E:
Local cyclic adenosine monophosphate signalling cascades-Roles and targets in chronic kidney disease
Acta Physiol (Oxf). 2021 May, DOI: 10.1111/apha.13641  PMID: 33660401

Savoia C, Volpe M, Kreutz R:
Hypertension, a Moving Target in COVID-19: Current Views and Perspectives
Circ Res. 2021 Apr 2, DOI: 10.1161/CIRCRESAHA.121.318054 PMID: 33793331

Jobin K, Müller DN, Jantsch J, Kurts C:
Sodium and its manifold impact on our immune system
Trends Immunol. 2021 Jun, DOI: 10.1016/j.it.2021.04.002 PMID: 33962888

Kedziora SM, Kräker K, Markó L, Binder J, Sugulle M, Gauster M, Müller DN, Dechend R, Haase N, Herse F:
Kidney Injury Caused by Preeclamptic Pregnancy Recovers Postpartum in a Transgenic Rat Model
Int J Mol Sci. 2021 Apr 5, DOI: 10.3390/ijms22073762 PMID: 33916404

Starke L, Niendorf T, Waiczies S:
Data Preparation Protocol for Low Signal-to-Noise Ratio Fluorine-19 MRI
Methods Mol Biol. 2021, DOI: 10.1007/978-1-0716-0978-1_43  PMID: 33476033

Periquito JS, Starke L, Santos CM, Freitas AC, Loução N, Polo PG, Nunes RG, Niendorf T, Pohlmann A:
Analysis Protocols for MRI Mapping of the Blood Oxygenation-Sensitive Parameters T 2* and T 2 in the Kidney
Methods Mol Biol. 2021, DOI: 10.1007/978-1-0716-0978-1_36 PMID: 33476026

Hu W, Jiang S, Liao Y, Li J, Dong F, Guo J, Wang X, Fei L, Cui Y, Ren X, Xu N, Zhao L, Chen L, Zheng Y, Li L, Patzak A, Persson PB, Zheng Z, Lai EY:
High phosphate impairs arterial endothelial function through AMPK-related pathways in mouse resistance arteries
Acta Physiol (Oxf). 2021 Apr, DOI: 10.1111/apha.13595 PMID: 33835704

Zhang Y, Xu C, Ye Q, Tong L, Jiang H, Zhu X, Huang L, Lin W, Fu H, Wang J, Persson PB, Lai EY, Mao J:
Podocyte apoptosis in diabetic nephropathy by BASP1 activation of the p53 pathway via WT1
Acta Physiol (Oxf). 2021 May, DOI: 10.1111/apha.13634 PMID: 33615732

Xue P, Bai Y, Rottwinkel G, Averbukh E, Ma Y, Roeder T, Scheerer P, Krauß N, Lamparter T:
Phytochrome Mediated Responses in Agrobacterium fabrum: Growth, Motility and Plant Infection
Curr Microbiol. 2021 May 22, DOI: 10.1007/s00284-021-02526-5 PMID: 34023916

Bader M, Turner AJ, Alenina N:
ACE2, a multifunctional protein - from cardiovascular regulation to COVID-19
Clin Sci (Lond). 2020 Dec 11;134(23):3229-3232. doi: 10.1042/CS20201493 PMID: 33305790

Scholz H, Boivin FJ, Schmidt-Ott KM, Bachmann S, Eckardt KU, Scholl UI, Persson PB:
Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection
Nature Reviews Nephrology 2021 Feb 5 doi: 10.1038/s41581-021-00394-7 PMID: 33547418                                                                                                                                                                            
                                                                                                    
Hu J, Xu Y, Bachmann S, Mutig K:
Angiotensin II receptor blockade alleviates calcineurin inhibitor nephrotoxicity by restoring cyclooxygenase 2 expression in kidney cortex
Acta Physiologica 2020 Dec 29 doi: 10.1111/apha.13612 PMID: 33377278                                                                             

Xu Y, Hu J, Yilmaz DE, Bachmann S:
Connexin43 is differentially distributed within renal vasculature and mediates profibrotic differentiation in medullary fibroblasts
American journal of physiology. Renal physiology 2021 Jan 1 doi: 10.1152/ajprenal.00453.2020 PMID: 33196322

Ni J, Yang F, Huang XR, Meng J, Chen J, Bader M, Penninger JM, Fung E, Yu XQ, Lan HY:    
Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy
J Cell Mol Med 2020 Nov; 24(22):13093-13103 doi: 10.1111/jcmm.15914 PMID:32971570                                                       

Ku MC, Schreiber A, Delgado PR, Boehm-Sturm P, Kettritz R, Niendorf T, Pohlmann A, Waiczies S:
Fluorine (19 F) MRI for Assessing Inflammatory Cells in the Kidney: Experimental Protocol
Methods Mol Biol 2021;2216:495-507.PMID: 33476020

Starke L, Tabelow K, Niendorf T, Pohlmann A:
Denoising for Improved Parametric MRI of the Kidney: Protocol for Nonlocal Means Filtering
Methods Mol Bio 2021 doi: 10.1007/978-1-0716-0978-1_34 PMID: 33476024                                                                                                                                                                    

Riazy L, Milani B, Periquito JS, Cantow K, Niendorf T, Priujm M, Seeliger E, Pohlmann A:
Subsegmentation of the Kidney in Experimental MR Images Using Morphology-Based Regions-of-Interest or Multiple-Layer Concentric Objects
Methods Mol Bio 2021 doi: 10.1007/978-1-0716-0978-1_33 PMID: 33476023                                                                                   

Periquito JS, Meier M, Niendorf T, Pohlmann A, Jerome NP:
Renal MRI Diffusion: Experimental Protocol
Methods Mol Bio 2021 doi: 10.1007/978-1-0716-0978-1_24 PMID:33476014                                                                                                                                                                                                    

Pohlmann A, Zhao K, Fain SB, Prasad P, Niendorf T:
Experimental Protocol for MRI Mapping of the Blood Oxygenation-Sensitive Parameters T ₂* and T ₂ in the Kidney
Methods Mol Bio 2021 doi: 10.1007/978-1-0716-0978-1_23 PMID: 33476013                                                                                                                                   

Pohlmann A, Periquito JS, Niendorf T:
Essential Practical Steps for MRI of the Kidney in Experimental Research
Methods Mol Bio 2021 doi: 10.1007/978-1-0716-0978-1_20 PMID: 33476010                                                                                                                                                                                                        

Cantow K, Ladwig-Wiegard M, Flemming B, Pohlmann A, Niendorf T, Seeliger E:
Monitoring Renal Hemodynamics and Oxygenation by Invasive Probes: Experimental Protocol
Methods Mol Bio 2021 doi: 10.1007/978-1-0716-0978-1_19 PMID: 33476009                                                                                                                                                                  

Waiczies S, Prinz C, Starke L, Millward JM, Delgado PR, Rosenberg J, Nazaré M, Waiczies H, Pohlmann A,  Niendorf T:
Functional Imaging Using Fluorine (19 F) MR Methods: Basic Concepts
Methods Mol Bio 2021 doi: 10.1007/978-1-0716-0978-1_17 PMID: 33476007                                                                                                         

Ku MC, Fernández-Seara MA, Kober F, Niendorf T:
Noninvasive Renal Perfusion Measurement Using Arterial Spin Labeling (ASL) MRI: Basic Concept
Methods Mol Bio 2021 doi: 10.1007/978-1-0716-0978-1_13 PMID: 33476003

Ramos Delgado P, Küstermann E, Kühne A, Millward JM, Niendorf T, Pohlmann A, Meier M:
Hardware Considerations for Preclinical Magnetic Resonance of the Kidney
Methods Mol Bio 2021 doi: 10.1007/978-1-0716-0978-1_8 PMID: 33475998                                                                                                                

Cantow K, Evans RG, Grosenick D, Gladytz T,  Niendorf T, Flemming B, Seeliger E:
Quantitative Assessment of Renal Perfusion and Oxygenation by Invasive Probes
Basic ConceptsMethods Mol Bio 2021 doi: 10.1007/978-1-0716-0978-1_6 PMID: 33475996                                                                                             

Millward JM, Periquito JS, Delgado PR, Prinz C, Niendorf T, Waiczies S:
Preparation of Ex Vivo Rodent Phantoms for Developing, Testing, and Training MR Imaging of the Kidney and Other Organs
Methods Mol Bio 2021 doi: 10.1007/978-1-0716-0978-1_5 PMID: 33475995            

Pohlmann A, Back SJ, Fekete A, Friedli I, Hectors S, Jerome NP, Ku MC, Longo DL, Meier M, Millward JM, Periquito JS, Seeliger E, Serai SD, Waiczies S, Sourbron S, Laustsen C,  Niendorf T:
Recommendations for Preclinical Renal MRI: A Comprehensive Open-Access Protocol Collection to Improve Training, Reproducibility, and Comparability of Studies
Methods Mol Bio 2021 doi: 10.1007/978-1-0716-0978-1_1 PMID: 33475991 

Zhou S, Guo J, Zhao L, Liao Y, Zhou Q, Cui Y, Hu W, Chen J, Ren X, Wei Q, Jiang S, Zheng Y, Li L, Wilcox CS, Persson PB,  Patzak A, Tian J, Yin Lai E:
ADAMTS13 inhibits oxidative stress and ameliorates progressive chronic kidney disease following ischaemia/reperfusion
Acta Physiologica, 2020 Nov doi: 10.1111/apha.13586. Epub 2020 Dec 1 PMID: 33226724

Stölting G, Scholl UI:
CACNA1H Calcium Channel Mutations in Primary Aldosteronism - Is Sodium the Culprit?
Endocrinology, 2020 Dec doi: 10.1210/endocr/bqaa173 PMID: 33142317

Zhao KX, Pohlmann A, Feng QJ, Mei YJ, Yang GX, Yi PW, Feng QJ, Chen WF, Zhou LL, Wu EX, Seeliger E, Niendorf T, Feng YQ:
Physiological System Analysis of the Kidney by High‐Temporal‐Resolution T₂^* monitoring of an oxygenation step response
Magn Reson Med. 85:334-345, 2021 doi: 10.1002/mrm.28399. PMID: 32710578

Pallien T, Klussmann E:
New aspects in cardiac L-type Ca2+ channel regulation.
Biochem Soc Trans. 2020 Feb 28;48(1):39-49. doi: 10.1042/BST20190229. PMID: 32065210

Heyne HO, Baez-Nieto D, Iqbal S, Palmer DS, Brunklaus A, May P; Epi25 Collaborative, Johannesen KM, Lauxmann S, Lemke JR, Møller RS, Pérez-Palma E, Scholl UI, Syrbe S, Lerche H, Lal D, Campbell AJ, Wang HR, Pan J, Daly MJ:
Predicting functional effects of missense variants in voltage-gated sodium and calcium channels.
Sci Transl Med. 2020 Aug 12;12(556):eaay6848. doi: 10.1126/scitranslmed.aay6848. PMID: 32801145

Millward JM, Ramos Delgado P, Smorodchenko A, Boehmert L, Periquito J, Reimann HM, Prinz C, Els A, Scheel M, Bellmann-Strobl J, Waiczies H, Wuerfel J, Infante-Duarte C, Chien C, Kuchling J, Pohlmann A, Zipp F, Paul F, Niendorf T, Waiczies S:
Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis.
JCI Insight 2020; 5:e140040 PMID: 33148886

Ji Y, Winter L, Navarro L, Ku MC, Periquito JS, Pham M, Hoffmann W, Theune LE, Calderón M, Niendorf T:
Controlled Release of Therapeutics from Thermoresponsive Nanogels: A Thermal Magnetic Resonance Feasibility Study.
Cancers (Basel) 2020; 12:1380 PMID: 32471299

Neumeier LI, Thomson RB, Reichel M, Eckardt KU, Aronson PS, Knauf F. Enteric:
Oxalate Secretion Mediated by Slc26a6 Defends against Hyperoxalemia in Murine Models of Chronic Kidney Disease
J Am Soc Nephrol. 2020 Sep;31(9):1987-1995.doi: 10.1681/ASN.2020010105. Epub 2020 Jul 13. PMID: 32660969; PMCID:PMC7461683.

Ljimani A, Caroli A, Laustsen C, Francis S, Mendichovszky IA, Bane O, Nery F, Sharma K, Pohlmann A, Dekkers IA, Vallee JP, Derlin K, Notohamiprodjo M, Lim RP, Palmucci S, Serai SD, Periquito J, Wang ZJ, Froeling M, Thoeny HC, Prasad P, Schneider M, Niendorf T, Pullens P, Sourbron S, Sigmund EE:
Correction to: Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.
MAGMA 2020; 33:197-198 PMID: 31989377

Ljimani A, Caroli A, Laustsen C, Francis S, Mendichovszky IA, Bane O, Nery F, Sharma K, Pohlmann A, Dekkers IA, Vallee JP, Derlin K, Notohamiprodjo M, Lim RP, Palmucci S, Serai SD, Periquito J, Wang ZJ, Froeling M, Thoeny HC, Prasad P, Schneider M, Niendorf T, Pullens P, Sourbron S, Sigmund EE:
Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI
MAGMA 2020;33(1):177-195.PMID: 31676990

Simons M, Bader M, Müller DN:
The (pro)renin receptor: what's in a name?
Nat Rev Nephrol 2020; 16(5):304. PMID: 32238922

Bader M:
ACE2 – the hijacked all-rounder
Nephrologe 2020, 15:1-4; doi.org/10.1007/s11560-020-00448-0 PMID: 32837572

Zhou S, Jiang S, Guo J, Xu N, Wang Q, Zhang G, Zhao L, Zhou Q, Fu X, Li L, Patzak A, Hultström M, Lai EY:
ADAMTS13 protects mice against renal ischemia-reperfusion injury by reducing inflammation and improving endothelial function
Am J Physiol Renal Physiol. 2019 Jan 1;316(1):F134-F145. PMID: 30461292

Zhao L, Cao X, Li L, Wang X, Wang Q, Jiang S, Tang C, Zhou S, Xu N, Cui Y, Hu W, Fei L, Zheng Z, Chen L, Schmidt MO, Wei Q, Zhao J, Labes R, Patzak A, Wilcox CS, Fu X, Wellstein A, Lai EY:
Acute Kidney Injury Sensitizes the Brain Vasculature to Ang II (Angiotensin II) Constriction via FGFBP1 (Fibroblast Growth Factor Binding Protein 1)
Hypertension. 2020 Dec;76(6):1924-1934. doi: 10.1161/HYPERTENSIONAHA.120.15582.

Wennysia IC, Zhao L, Schomber T, Braun D, Golz S, Summer H, Benardeau A, Lai EY, Lichtenberger FB, Schubert R, Persson PB, Xu MZ, Patzak A:
Role of soluble guanylyl cyclase in renal afferent and efferent arterioles
Am J Physiol Renal Physiol. 2021 Feb 1;320(2):F193-F202. doi: 10.1152/ajprenal.00272.2020. Epub 2020 Dec 28.

Kräker K, Herse F, Golic M, Reichhart N, Crespo-Garcia S, Strauß O, Grune J, Kintscher U, Ebrahim M, Bader M, Alenina N, Heuser A, Luft FC, Müller DN, Dechend R, Haase N:
Effects of Empagliflozin and Target-Organ Damage in a Novel Rodent Model of Heart Failure Induced by Combined Hypertension and Diabetes
Sci Rep. 10:14061, 2020 doi: 10.1038/s41598-020-70708-5. PMID: 32820187 Free PMC article.

Ni J, Yang F, Huang XR, Meng J, Chen J, Bader M, Penninger JM, Fung E, Yu XQ, Lan HY:
Dual Deficiency of Angiotensin-Converting Enzyme-2 and Mas Receptor Enhances Angiotensin II-Induced Hypertension and Hypertensive Nephropathy
J Cell Mol Med. 2020 Sep 24. doi: 10.1111/jcmm.15914. Online ahead of print. PMID: 32971570 Free PMC article.

Pfau A, Wytopil M, Chauhan K, Reichel M, Coca SG, Aronson PS, Eckardt KU, Knauf F: 
Assessment of Plasma Oxalate Concentration in Patients with CKD
Kidney Int Rep. 5:2013-2020, 2020 doi: 10.1016/j.ekir.2020.08.029. eCollection 2020 Nov. PMID: 33163722 Free PMC article.

Kling L, Schreiber A, Eckardt KU, Kettritz R:
Hypoxia-Inducible Factors not only Regulate but also are Myeloid-Cell Treatment Targets
J Leukoc Biol. 2020 Oct 18. doi: 10.1002/JLB.4RI0820-535R. Online ahead of print. PMID: 33070368

Balcerek B, Steinach M, Lichti J, Maggioni MA, Becker PN, Labes R, Gunga HC, Persson PB, Fähling M:
A Broad Diversity in Oxygen Affinity to Haemoglobin
Sci Rep. 10:16920, 2020 doi: 10.1038/s41598-020-73560-9. PMID: 33037242 Free PMC article.

Ostroverkhova DS, Hu J, Tarasov VV, Melnikova TI, Porozov YB, Mutig K:
Calcium-Sensing Receptor and Regulation of WNK Kinases in the Kidney
Cells. 9:1644, 2020 doi: 10.3390/cells9071644. PMID: 32659887 Free PMC article.

Kleinau G, Heyder NA, Tao YX, Scheerer P:
Structural Complexity and Plasticity of Signaling Regulation at the Melanocortin-4 Receptor
Int J Mol Sci. 21:5728, 2020 doi: 10.3390/ijms21165728. PMID: 32785054 Free PMC article.

Schulze A, Kleinau G, Neumann S, Scheerer P, Schöneberg T, Brüser A:
The Intramolecular Agonist is Obligate for Activation of Glycoprotein Hormone Receptors
FASEB J. 34:11243-11256, 2020 doi: 10.1096/fj.202000100R. PMID: 32648604

Stölting G, Scholl UI:
CACNA1H Calcium Channel Mutations in Primary Aldosteronism - Is Sodium the Culprit?
Endocrinology. 161:bqaa173, 2020 doi: 10.1210/endocr/bqaa173. PMID: 33142317 Free PMC article.

Ercu M, Marko L, Schächterle C, Tsvetov D, Cui Y, Maghsodi S, Bartolomaeus TUP, Maass PG, Zühlke K, Gregersen N, Hübner N, Hodge R, Mühl A, Pohl B, Illas RM, Geelhaar A, Walter S, Napieczynska H, Schelenz S, Taube M, Heuser A, Anistan YM, Qadri F, Todiras M, Plehm R, Popova E, Langanki R, Eichhorst J, Lehrmann M, Wiesner B, Russwurm M, Forslund SK, Kamer I, Müller DN, Gollasch M, Ayden A, Bähring S, Bader M, Luft FC, Klussmann E:
Phosphodiesterase 3A and Arterial Hypertension
Circulation. 142:133-149, 2020 doi: 10.1161/CIRCULATIONAHA.119.043061 PMID:32524868

Spasova K, Fähling M:
D-serine - A Useful Biomarker for Renal Injury?
Acta Physiol (Oxf). 230:e13531, 2020 doi: 10.1111/apha.13531. PMID: 32621380

Schreiber A, Rousselle A, Klocke J, Bachmann S, Popovic S, Bontscho J, Schmidt-Ott KM, Siffrin V, Jerke U, Ashraf MI, Panzer U, Kettritz R:
Neutrophil Gelatinase-Associated Lipocalin Protects From ANCA-Induced GN by Inhibiting T H 17 Immunity
JASN 31:1569-1584, 2020 doi: https://doi.org/10.1681/ASN.2019090879 PMID: 32487561

Bartolomaeus H, Avery EG, Bartolomaeus TUP, Kozhakhmetov S, Zhumadilov Z, Müller DN, Wilck N, Kushugulova A, Forslund SK:
Blood Pressure Changes Correlate with Short-Chain Fatty Acid Production Potential Shifts Under a Synbiotic Intervention
Cardiovasc Res 116:1252-1253, 2020 doi:10.1093/cvr/cvaa083. PMID: 32232443 

Zhao KX, Pohlmann A, Feng QJ, Mei YJ, Yang GX, Yi PW, Feng QJ, Chen WF, Zhou LL, Wu EX, Seeliger E, Niendorf T, Feng YQ:
Physiological System Analysis of the Kidney by High‐Temporal‐Resolution T₂^* Monitoring of an Oxygenation Step Response
Magn Reson Med. 85:334-345, 2021 doi: 10.1002/mrm.28399. PMID: 32710578 

Mangelsen E, Rothe M, Schulz A, Kourpa A, Panáková D, Kreutz R, Bolbrinker J:
Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E2 Activation in Human Podocytes
Cells 9:1256, 2020 doi: 10.3390/cells9051256. PMID: 32438662 Free PMC article. 
 
Delgado PR, Kuehne A, Periquito JS, Millward JM, Pohlmann A, Waiczies S, Niendorf T: 
B1 Inhomogeneity Correction of RARE MRI with Transceive Surface Radiofrequency Probes
Magn Reson Med. 84:2684-2701, 2020 doi: 10.1002/mrm.28307. PMID: 32447779 
 
Estrela GR, Wasinski F, Gregnani MF, Freitas-Lima LC, Arruda AC, Morais RL, Malheiros DM, Camara NOS, Pesquero JB, Bader M, Barros CC, Araújo RC:
Angiotensin-Converting Enzyme Inhibitor Protects Against Cisplatin Nephrotoxicity by Modulating Kinin B1 Receptor Expression and Aminopeptidase P Activity in Mice
Frontiers in Molecular Biosciences 7:96, 2020 doi: 10.3389/fmolb.2020.00096. PMID:32528973 

Bartolomaeus TUP, Brikner T, Bartolomaeus H, Löber U, Avery EG, Mähler A, Weber D, Kochlik B, Balogh A, Wilck N, Boschmann M, Müller DN, Markó L, Forslund SK:
Quantifying Technical Confounders in Microbiome Studies
Cardiovasc Res cvaa128, 2020 doi:10.1093/cvr/cvaa128 PMID:32374853  

Münch J, Kirschner KM, Schlee H, Kraus C, Schönauer R, Jin W, Duc DL, Scholz H, Halbritter J:
Autosomal Dominant Polycystic Kidney Disease in Absence of Renal Cyst Formation Illustrates Genetic Interaction between WT1 and PKD1
Journal of Genetics 106633, 2020 doi:10.1136/jmedgenet-2019-106633. PMID:32381729 

Dema A, Faust D, Lazarow K, Wippich M, Neuenschwander M, Zühlke K, Geelhaar A, Pallien T, Hallscheidt E, Eichhorst J, Wiesner B, Černecká H, Popp O, Mertins P, Dittmar G, von Kries JP, Klussmann E:
Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP
Cells 9:673, 2020 doi: 10.3390/cells9030673. 

Xu N, Jiang S, Persson PB, Persson EAG, Lai EY, Patzak A:
Reactive Oxygen Species in Renal Vascular Function
Acta Physiologica 229:e13477, 2020 DOI: 10.1111/apha.13477 PMID:32311827 

Markó L, Park JK, Henke N, Rong S, Balogh A, Klamer S, Bartolomaeus H, Wilck N, Ruland J, Forslund SK, Luft FC, Dechend R, Müller DN:
B-Cell Lymphoma/Leukaemia 10 and Angiotensin II-Induced Kidney Injury
Cardiovasc Res 116:1059-1070 2020 doi:10.1093/cvr/cvz169 PMID:31241148 

Kreutz R, Algharably EAEH, Azizi M, Dobrowolski P, Guzik T, Januszewicz A, Persu A, Prejbisz, Riemer TG, Wang JG, Burnier M:
Hypertension, the Renin-Angiotensin System, and the Risk of Lower Respiratory Tract Infections and Lung Injury: Implications for COVID-19
Cardiovasc Res cvaa097, 2020 doi: 10.1093/cvr/cvaa097. PMID:32293003

Boehmert L, Waiczies H, Kuehne A, Oezerdem C, Waiczies S, Starke L, Ku MC, Pohlmann A, Seeliger E, Niendorf T:
Cardiorenal Sodium MRI in Small Rodents Using a Quadrature Birdcage Volume Resonator at 9.4 T
MAGMA 33:121-130, 2020 doi: 10.1007/s10334-019-00810-x.

Niendorf T, Frydman L, Neeman M, Seeliger E:
Google Maps for Tissues: Multiscale Imaging of Biological Systems and Disease
Acta Physiol 228:e13392, 2020 doi: 10.1111/apha.13392.

Arends CM, Weiss M, Christen F, Eulenberg-Gustavus C, Rousselle A, Kettritz R, Eckardt KU, Chan W, Hoyer K, Frick M, Bullinger L, Bieringer M, Schreiber A, Damm F:
Clonal Hematopoiesis in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Haematologica 105:e264-e267, 2020 doi: 10.3324/haematol.2019.223305. 

Niendorf T, Seeliger E, Cantow K, Flemming B, Waiczies S, Pohlmann A:
Probing Renal Blood Volume with Magnetic Resonance Imaging
Acta Physiol 228:e13435, 2020 doi: 10.1111/apha.13435

Starke L, Pohlmann A, Prinz C, Niendorf T, Waiczies:
Performance of Compressed Sensing for Fluorine-19 Magnetic Resonance Imaging at Low Signal-To-Noise Ratio Conditions
Magn Reson Med 84:592-608, 2020 doi: 10.1002/mrm.28135.

Kong W, Haschler TN, Nürnberg B, Krämer S, Gollasch M, Markó L:
Renal Fibrosis, Immune Cell Infiltration and Changes of TRPC Channel Expression after Unilateral Ureteral Obstruction in Trpc6-/- Mice.
Cell Physiol Biochem. 2019;52(6):1484-1502. doi: 10.33594/000000103. PMID: 31099508

Leiz J, Schmidt-Ott KM:
Claudins in the Renal Collecting Duct.
Int J Mol Sci. 2019 Dec 28;21(1):221. doi: 10.3390/ijms21010221. PMID: 31905642

Giesecke T, Himmerkus N, Leipziger J, Bleich M, Koshimizu TA, Fähling M, Smorodchenko A, Shpak J, Knappe C, Isermann J, Ayasse N, Kawahara K, Schmoranzer J, Gimber N, Paliege A, Bachmann S, Mutig K:
Vasopressin Increases Urinary Acidification via V1a Receptors in Collecting Duct Intercalated Cells.
J Am Soc Nephrol. 2019 Jun;30(6):946-961. doi: 10.1681/ASN.2018080816. Epub 2019 May 16. PMID: 31097611

Bartolomaeus H, Balogh A, Yakoub M, Homann S, Markó L, Höges S, Tsvetkov D, Krannich A, Wundersitz S, Avery EG, Haase N, Kräker K, Hering L, Maase M, Kusche-Vihrog K, Grandoch M, Fielitz J, Kempa S, Gollasch M, Zhumadilov Z, Kozhakhmetov S, Kushugulova A, Eckardt KU, Dechend R, Rump LC, Forslund SK, Müller DN, Stegbauer J, Wilck N:
Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage.
Circulation. 2019 Mar 12;139(11):1407-1421. doi: 10.1161/CIRCULATIONAHA.118.036652. PMID: 30586752
 

Göppner C, Orozco IJ, Hoegg-Beiler MB, Soria AH, Hübner CA, Fernandes-Rosa FL, Boulkroun S, Zennaro MC, Jentsch TJ:
Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism
Nat Commun. 2019 Oct 15;10(1):4678. doi: 10.1038/s41467-019-12113-9. PMID: 31615979

Schewe J, Seidel E, Forslund S, Marko L, Peters J, Muller DN, Fahlke C, Stötling G, Scholl U:   
Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation
Nat Commun 10:5155:e13033, 2019 doi: 10.1038/s41467-019-13033-4.

Schulz A, Müller NV, van de Lest NA, Eisenreich A, Schmidbauer M, Barysenka A, Purfürst B, Sporbert A, Lorenzen T, Meyer AM, Herlan L, Witten A, Rühle F, Zhou W, de Heer E, Scharpfenecker M, Panáková D, Stoll M, Kreutz R:
Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage
eLife 8:e42068, 2019 doi: 10.7554/eLife.42068. PMID: 30900988 Free PMC article.

Zhao X, Nedvetsky P, Stanchi F, Vion AC, Popp O, Zühlke K, Dittmar G, Klussmann E, Gerhardt H:
Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1.
eLife 8:e46380, 2019 doi: 10.7554/eLife.46380.

Heß V, Kasim M, Mathia S, Persson PB, Rosenberger C, Fähling M:
Episodic Hypoxia Promotes Defence Against Cellular Stress
Cell Physiol Biochem 52:1075-1091, 2019 doi: 10.33594/000000073.

Seeliger E, Persson PB:
Kidney damage by iodinated contrast media
Acta Physiol 227:e13259, 2019 doi: 10.1111/apha.13259.

Jiang S, Wang X, Wei j, Zhang G, Zhang J, Xie P, Xu L, Wang L, Zhao L, Li L, Wilcox CS, Chen J, Lai EY, Liu R:
NaHCO3 Dilates Mouse Afferent Arteriole Via Na+/HCO3− Cotransporters NBCs
Hypertension 74:1104-1112, 2019 doi: 10.1161/HYPERTENSIONAHA.119.13235.

Khadzhynov D, Schmidt D, Hardt J, Rauch G, Gocke P, Eckardt KU, Schmidt-Ott KM:
The Incidence of Acute Kidney Injury and Associated Hospital Mortality
Dtsch Arztebl Int. 116:397-404, 2019 doi: 10.3238/arztebl.2019.0397.

Vukićević T, Hinze C, Baltzer S, Himmerkus N, Quintanova C, Zühlke K, Compton F, Ahlborn R, Dema A, Eichhorst J, Wiesner B, Bleich M, Schmidt-Ott KM, Klussmann E:
Fluconazole Increases Osmotic Water Transport in Renal Collecting Duct through Effects on Aquaporin-2 Trafficking
J Am Soc Nephrol 30:795-810, 2019 doi: 10.1681/ASN.2018060668.

Vigolo E, Marko L, Hinze C, Müller DN, Schmidt-Ulrich R, Schmidt-Ott KM:
Canonical BMP signaling in tubular cells mediates recovery after acute kidney injury
Kidney Int 95:108-122, 2019 doi: 10.1016/j.kint.2018.08.028.

Chen W, Alshaikh A, Kim S, Kim J, Chun C, Mehrazarin S, Lee J, Lux R, Kim RH, Shin KH, Park NH, Walentin K, Schmidt-Ott KM, Kang MK:
Porphyromonas gingivalis Impairs Oral Epithelial Barrier through Targeting GRHL2
J Dent Res 98:1150-1158, 2019 doi: 10.1177/0022034519865184.

Hariharan K, Stachelscheid H, Rossbach B, Oh SJ, Mah N, Schmidt-Ott K, Kurtz A, Reinke P:
Parallel generation of easily selectable multiple nephronal cell types from human pluripotent stem cells
Cell Mol Life Sci 76:179-192, 2019 doi: 10.1007/s00018-018-2929-2.

Periquito JDS, Paul K, Huelnhagen T, Ku MC, Ji Y, Cantow K, Gladytz T, Grosenick D, Flemming B, Seeliger E, Waiczies S, Niendorf T, Pohlmann A:
Diffusion-weighted Renal MRI at 9.4 Tesla Using RARE to Improve Anatomical Integrity
Sci Rep 9:19723, 2019 doi: 10.1038/s41598-019-56184-6